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Database: UniProt
Entry: I3K3E3_ORENI
LinkDB: I3K3E3_ORENI
Original site: I3K3E3_ORENI 
ID   I3K3E3_ORENI            Unreviewed;      1078 AA.
AC   I3K3E3;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   24-JAN-2024, entry version 80.
DE   SubName: Full=Toll-like receptor 9 {ECO:0000313|Ensembl:ENSONIP00000015638.1};
GN   Name=LOC100696189 {ECO:0000313|Ensembl:ENSONIP00000015638.1};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000015638.1, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000015638.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC       {ECO:0000256|ARBA:ARBA00009634}.
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DR   RefSeq; XP_005478038.1; XM_005477981.3.
DR   AlphaFoldDB; I3K3E3; -.
DR   STRING; 8128.ENSONIP00000015638; -.
DR   Ensembl; ENSONIT00000015652.2; ENSONIP00000015638.1; ENSONIG00000012415.2.
DR   GeneID; 100696189; -.
DR   KEGG; onl:100696189; -.
DR   CTD; 54106; -.
DR   eggNOG; KOG4641; Eukaryota.
DR   GeneTree; ENSGT00940000163875; -.
DR   InParanoid; I3K3E3; -.
DR   OMA; NFLPCCS; -.
DR   OrthoDB; 4603490at2759; -.
DR   TreeFam; TF325595; -.
DR   Proteomes; UP000005207; Linkage group LG20.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR   PANTHER; PTHR47410:SF4; TOLL-LIKE RECEPTOR 9; 1.
DR   Pfam; PF00560; LRR_1; 2.
DR   Pfam; PF13855; LRR_8; 3.
DR   Pfam; PF01582; TIR; 1.
DR   SMART; SM00364; LRR_BAC; 7.
DR   SMART; SM00365; LRR_SD22; 5.
DR   SMART; SM00369; LRR_TYP; 12.
DR   SMART; SM00082; LRRCT; 1.
DR   SUPFAM; SSF52058; L domain-like; 3.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS51450; LRR; 6.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..1078
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003673726"
FT   TRANSMEM        861..883
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          915..1061
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   1078 AA;  124397 MW;  D4DE988CCEEDCF02 CRC64;
     MHSSCAVALV KNILILSQLF PLVKTINTKF LPCDTNLNET KVDCSDRPLK HVPFIKATSV
     AYIDLSRTKI NRVWPHAFTG VPNLHTLKLS GNCQPGSPRA LEDRSCRVKI SRYAFKPLLT
     LKHLDLSGNS LTYIPWLPES LEVLHLENNQ IFNVIYPLKT PHLEKLFLSK NCFYANPCNQ
     SFYISEKVFQ ELPKLKNLTL GYNNLTAIPK GLPLSLGSLD LRENTITEVL EKAFFKMTAL
     EDLNLEWNCQ RCDHAARPCF PCPHNQSLKL HSNSFYSENS SITILSLRGN SLRTFPKGLF
     RPLKKLKILD LSDNLLAYAM QNGTFFKELT GVEWLSLIYN YEPLKTFPEL NLSPYFNNMS
     DLQCLLLSGN FFLKFSNESI EVLSKLKSLK VLELRMNFIN TFNMTFLKQL PSLTSVDLSQ
     NMLNFLQCCS ISRSEIVDEN LYAGTLHNQP LTLMAKEVTS RNSVWETEQL NALEILEDSV
     TDIPTLLDFQ LRADVLDKRF PVITSLWDLR NFHCKNKLTF DLSQNDIVYL NKHVVSGMEN
     AVCLDLSFNY MNQALRGGVF EGMTHLEFLN LSYNRLDLYY NDAFRELNSS LKILDISNNE
     FHFNMRGMGH RFEFLENLNQ LEALSLANNA IGMRINQRLI CNSLKYFDFS GNNLNIMWDS
     DNNKYTNFFQ NLANLTYLDI SNNHLKSLSS EVLCNLPSSL RALIISSNSL NYFPWLNISA
     LTSLHYLNLN HNFLYKLPNY AVIFGVNFTF LDLSHNRISY IPEDFFNNAK SLKYLYLSHN
     QIKELNREHL PVLFKNDTRL ENLTLHANPF KCDCNTSWLA DFLSTTPVHI PYLTTDVRCE
     FPESQQGESI LSMDQRSCQD IYGSVAFVAC SFMTLVFTVL PLLKHLYGWD MWYCLQVLWA
     GHKGYSQIAG TDSHYQYDAF VVFDTSNQAV RDWVYNELTV NLENSGHRRF CLCLEERDWI
     PGLSCIENLH NAVYRSVKTV FVLSRGVNGN VNGVIRQAFF MVQQRLLDEK VDVAVLVLMD
     KMFPKLKYLQ LRKRLCRKSV LSWPHHPCAQ PLFWNQMRMA LSSDNLKFYD NNMSESFI
//
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