ID I3K3E3_ORENI Unreviewed; 1078 AA.
AC I3K3E3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 24-JAN-2024, entry version 80.
DE SubName: Full=Toll-like receptor 9 {ECO:0000313|Ensembl:ENSONIP00000015638.1};
GN Name=LOC100696189 {ECO:0000313|Ensembl:ENSONIP00000015638.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000015638.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000015638.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR RefSeq; XP_005478038.1; XM_005477981.3.
DR AlphaFoldDB; I3K3E3; -.
DR STRING; 8128.ENSONIP00000015638; -.
DR Ensembl; ENSONIT00000015652.2; ENSONIP00000015638.1; ENSONIG00000012415.2.
DR GeneID; 100696189; -.
DR KEGG; onl:100696189; -.
DR CTD; 54106; -.
DR eggNOG; KOG4641; Eukaryota.
DR GeneTree; ENSGT00940000163875; -.
DR InParanoid; I3K3E3; -.
DR OMA; NFLPCCS; -.
DR OrthoDB; 4603490at2759; -.
DR TreeFam; TF325595; -.
DR Proteomes; UP000005207; Linkage group LG20.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR PANTHER; PTHR47410:SF4; TOLL-LIKE RECEPTOR 9; 1.
DR Pfam; PF00560; LRR_1; 2.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00364; LRR_BAC; 7.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 12.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 6.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..1078
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003673726"
FT TRANSMEM 861..883
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 915..1061
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1078 AA; 124397 MW; D4DE988CCEEDCF02 CRC64;
MHSSCAVALV KNILILSQLF PLVKTINTKF LPCDTNLNET KVDCSDRPLK HVPFIKATSV
AYIDLSRTKI NRVWPHAFTG VPNLHTLKLS GNCQPGSPRA LEDRSCRVKI SRYAFKPLLT
LKHLDLSGNS LTYIPWLPES LEVLHLENNQ IFNVIYPLKT PHLEKLFLSK NCFYANPCNQ
SFYISEKVFQ ELPKLKNLTL GYNNLTAIPK GLPLSLGSLD LRENTITEVL EKAFFKMTAL
EDLNLEWNCQ RCDHAARPCF PCPHNQSLKL HSNSFYSENS SITILSLRGN SLRTFPKGLF
RPLKKLKILD LSDNLLAYAM QNGTFFKELT GVEWLSLIYN YEPLKTFPEL NLSPYFNNMS
DLQCLLLSGN FFLKFSNESI EVLSKLKSLK VLELRMNFIN TFNMTFLKQL PSLTSVDLSQ
NMLNFLQCCS ISRSEIVDEN LYAGTLHNQP LTLMAKEVTS RNSVWETEQL NALEILEDSV
TDIPTLLDFQ LRADVLDKRF PVITSLWDLR NFHCKNKLTF DLSQNDIVYL NKHVVSGMEN
AVCLDLSFNY MNQALRGGVF EGMTHLEFLN LSYNRLDLYY NDAFRELNSS LKILDISNNE
FHFNMRGMGH RFEFLENLNQ LEALSLANNA IGMRINQRLI CNSLKYFDFS GNNLNIMWDS
DNNKYTNFFQ NLANLTYLDI SNNHLKSLSS EVLCNLPSSL RALIISSNSL NYFPWLNISA
LTSLHYLNLN HNFLYKLPNY AVIFGVNFTF LDLSHNRISY IPEDFFNNAK SLKYLYLSHN
QIKELNREHL PVLFKNDTRL ENLTLHANPF KCDCNTSWLA DFLSTTPVHI PYLTTDVRCE
FPESQQGESI LSMDQRSCQD IYGSVAFVAC SFMTLVFTVL PLLKHLYGWD MWYCLQVLWA
GHKGYSQIAG TDSHYQYDAF VVFDTSNQAV RDWVYNELTV NLENSGHRRF CLCLEERDWI
PGLSCIENLH NAVYRSVKTV FVLSRGVNGN VNGVIRQAFF MVQQRLLDEK VDVAVLVLMD
KMFPKLKYLQ LRKRLCRKSV LSWPHHPCAQ PLFWNQMRMA LSSDNLKFYD NNMSESFI
//