ID I3K3V1_ORENI Unreviewed; 861 AA.
AC I3K3V1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=WD repeat-containing protein 47 {ECO:0000313|Ensembl:ENSONIP00000015796.2};
GN Name=WDR47 {ECO:0000313|Ensembl:ENSONIP00000015796.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000015796.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000015796.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; I3K3V1; -.
DR Ensembl; ENSONIT00000015811.2; ENSONIP00000015796.2; ENSONIG00000012546.2.
DR GeneTree; ENSGT00940000155561; -.
DR HOGENOM; CLU_049080_0_0_1; -.
DR Proteomes; UP000005207; Linkage group LG15.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR006595; CTLH_C.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR040067; WDR47.
DR PANTHER; PTHR19863; NEMITIN (NEURONAL ENRICHED MAP INTERACTING PROTEIN) HOMOLOG; 1.
DR PANTHER; PTHR19863:SF5; WD REPEAT-CONTAINING PROTEIN 47; 1.
DR Pfam; PF17814; LisH_TPL; 1.
DR Pfam; PF00400; WD40; 6.
DR SMART; SM00668; CTLH; 1.
DR SMART; SM00667; LisH; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50897; CTLH; 1.
DR PROSITE; PS50896; LISH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 45..102
FT /note="CTLH"
FT /evidence="ECO:0000259|PROSITE:PS50897"
FT REPEAT 599..629
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 693..733
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 738..779
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 780..814
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 826..857
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 450..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 373..403
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 450..465
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 861 AA; 95173 MW; 1EECFEA0BAD2B1D2 CRC64;
MTAEETINIK EAEVTKLILD FLNSRKLHIS MLALEKESGV INGLYSDDML FLRQLILDGQ
WEEVMQFIQP LEGMDKFDKK RFRYIIFKQK FLEALCVNNA MSAAEDPLNL EITMQEAVKC
LHCLEEFCPT KEDYSKLCLL LTLPRLTHHA EFKDWNPSTA RVHCFEEACI MVAEFIPADR
KLSEAGFRAS GNRLFQLLIK GILYECCVEF CQSKATGEEI TEGEVLLGVD LLCGNGCDEL
DLSLLSWLQN LSPGAFTCAF QQKTLNIHVD RLVKPSKAGH ADLLTPLINR LSPCPTSPFR
QRPHSADTYM SRSLNPALDG LSHGLAAQDK RGLETNMKFA LSRSLPETSQ CHPPKSNTCV
LVCVQRRDST EHIQEYYRQR LRVQQHLEQK QQQKQLYQQM LLEGGVKPQD GAQHNLTETF
LSRSIQKLEE MNVGIDHRGE DMMAQLGQQW NGLTGNNSTS SPRVSHTRHT PDKGPPRDKP
GGVSSSTPVS TGSHSLPLLS ESPVPPNKRI TGSGPTVQDD STSSATRSTH EPAKSKTQFV
KVSQLEDTQA VRAVAFHPAG ALYAVGSNSK TLRVCAYPET LTASGSGAVK QPAVRFRRNK
HHKGSIYCVA WSHCGQLLAT GSNDKYVKVL PFNADTCNAT GPDLEFSMHD GTIRDLAFME
GPESGGSILI SAGAGDCNIY TTDCQRGQGL HALSGHTGHI LTLYTWGGWM IASGSQDKTV
RFWDLRVPSC VRVVGTTLHG TGSAVASVAV DPSGRLLATG QEDSTCMLYD IRGGRIVQTY
RPHSSDIRSV RFSPGAHHLL TGSYDNRIII SDLQGDLTKP LPQTVAGEHW DKVIQCRWHP
HDRTFVSSSA DRTVILWAPG P
//
