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Entry: I3K519_ORENI
LinkDB: I3K519_ORENI
Original site: I3K519_ORENI 
ID   I3K519_ORENI            Unreviewed;      2395 AA.
AC   I3K519;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   25-OCT-2017, entry version 37.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000016214, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000016214}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000016214}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [3] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSONIP00000016214}.
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DR   EMBL; AERX01004726; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01004727; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01004728; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01004729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01004730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01004731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01004732; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8128.ENSONIP00000016214; -.
DR   Ensembl; ENSONIT00000016229; ENSONIP00000016214; ENSONIG00000012883.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; I3K519; -.
DR   OMA; FREDNLI; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 2.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     96    113       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    134    155       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    167    187       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    222    245       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    298    319       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    331    353       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    517    536       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    642    664       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    720    742       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1176   1194       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1214   1234       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1246   1265       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1307   1329       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1419   1444       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1500   1518       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1530   1548       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1621   1639       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1710   1733       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1870   1904       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      738    765       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2395 AA;  269911 MW;  3167F1C6409079DB CRC64;
     MARFAEDLPT RYGGSAGGGG RGGPGAGRGG ARGGGAPGGQ RMYKQSMAQR ARTMAIYNPN
     PVKQNCFTVN RSLFIFREDN LIRKYAKRIT EWPTPFEYMI LATIIANCIV LALEQHLPAG
     DKTPMSERLD DTEPYFIGIF CFEAAIKIIA LGFAFHKGSY LRNGWNVMDF VVVLTGILAT
     VGSDFDLRTL RAVRVLRPLK LVSGIPSLQV VLKSIMKAMV PLLQIGLLLF FAIVMFAIIG
     VEFYMGKFHT TCFKNGTDER TADWPCGNEP PARTCPSGSE CKVYWTGPNF GITNFDNILF
     AVLTVFQCIT MEGWVDILYS TNDVAGNTWN WLYFIPLIII GSFFMLNLVL GVLSGEFAKE
     RERVEKRQEF LKLRRQQQIE RELTGYLEWI CKAEEVLLEE EDEIAEEKSP LDGAWYKRKQ
     NLPGGLGSSP ARNQFGCFLS SYRVLKRGKV KKGKNDLISA EEGEDPFADI SSVAPPGSPF
     GRASVKSSGK MDSSSYFRRK EKRIRFFIRR MVKAQSFYWI VLCVVGLNTL CVAIVHYDQP
     EWLTRALYTA EFVFLGLFLT EMTLKMYGLG VRNYFHSSFN CFDFGVIVGS IFEVIWDMIK
     PGASFGISVL RALRLLRIFK VTKYWNSLRN LVVSLLNSMK SIISLLFLLF LFIVVFALLG
     MQLFGGQFNF EDETPTTNFD TFPAAILTVF QILTGEDWNA VMYHGIESQG GVRGGMFSSI
     YFIVLTLFGN YTLLNVFLAI AVDNLANAQE LTKDEEEQEE AANKKLALQK ALEVKEVSPM
     SAANISIAAK EQQRSAKAMS VWEQRTNQLR RHNIKASSEA LYNELDPDDR LLMSSALHLH
     PDMKTHLDRP LRVESKNGDK SSRAPEGGWE EAGDLRQDDS FHPHSRKHHH HHDRSGESRD
     EGDVRGGRHH THHSRSRDHN ADGPQTKERR GEMSHNRNGG QGHRHHHHQA GSPEEENNDL
     RGGGGDNKGH HHHHSHRPPK EGNGMLANGA QSERRGRGGG GGDSNGERKD RCSRTGRAQT
     ALGGDDSKRN KNGNRGYRTL RSPGRNKQNK RYILDSDCSD CLGFPELPCA ALHKSPQQPT
     EDADNQKNST RASQAGLNSN AIHIPVTITA PPGETTIIPM NNIDCDNLQL SEEKKDLEED
     EAANGPRQIL PYSSMFIFSQ TNPVRRLCHY VVNLRYFEMC ILTVITMSSI ALAAEDPVQA
     NATRNDVLKY LDYVFTGVFT FEMVIKMIDL GLLLHPGSYF RDLWNILDFI VVSGALVAFA
     CSGTKGKDIN TIKSLRVLRV LRPLKTIKRL PKLKAVFDCV VNSLKNVLNI LIVYILFMFI
     FAVIAVQLFK GKFFYCSDES KTLEKDCRGQ FLDYDRDEVT AKPRVWKKYE FHYDNVLWAF
     LTLFTVSTGE GWPVVLKHSV DATYEDQGPS PGFRMETSIF YVVYFVVFPF FFVNIFVALI
     IITFQEQGDK AMSECTLEKN ERACIDFAIN AKPLTRYMPE NKQSFQYKMW KFVVSSPFEY
     AIMTLIALNT IVLMMKFYGA PDVYESMLKY LNIVFTGLFT LECILKIIAF NPLNYLKEPW
     NVFDFVTVIG SITDILCTEI NKEKINLSFL RLFRAARLIK LLRQGYTIRI LLWTFVQSFK
     ALPYVCLLIA MLFFIYAIIG MQVFGNIELI EENAINHHNN FQTFFQALTL LFRSATGEAW
     HEIMLACLSN RPCDKLSGTT GDECGSDFAY FYFVSFIFLC SFLMLNLFVA VIMDNFEYLT
     RDASILGPHH LDEFIRVWAE YDPAACGRIC YRDMYKLLHF ISPPLGLGKK CPSRVAYKRL
     VKMNMPIADD NTVHFTSTLM ALIRTALEIK LASGMLAQRL CDADLKREIN RVWPNLSQKT
     MDLLVTPHKY NELTVGKVYA ALMIYDFYKQ NRAKRLQQQN SSDGPCVPSS LSNLFVSILS
     HCEDNDPKHS ASAVKAYLDR KTHNETLSVM NWPQRSPDLN SIEAVWDHQP TFNDVFSTLC
     CPCFSRGFNC LPVLFEEIKL KSEQVELKQV ENTSDAEAYP SLEGHCRAAS LPRLNAEYYR
     SHPRHAPGTH LAPIVDLSPI KRSASSLTPQ HHYQDVGLKD YDLERPRMGQ VQGQDRAHHH
     HHHHRCHRRR DKDKDKKQKS LDRAASVQPS STVDSFTDPS AEGLSRERAR ERDRSRPHER
     RHHSSAGEKQ RYYSCERYGS REQSHTKSAG PSRSTSPGEG QDSGFLRQHG SSVVKSGHGT
     LPSGSSTPGR GRRQLPQTPL TPRPAVAYKT ANSNLPSSAI MATTGHQTRF SRGLSEHDRL
     LGAHEESPIP ITRIGSDPNL NRQQQDSSQK ALLDEEDFQD AVSSQGGGRS ARTAASTTAS
     ASHPTAATPV TAPTTQGRAV VMPNGYHFTL GVNSSSGPGN RGAGSLRERE EDDWC
//
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