ID I3K588_ORENI Unreviewed; 594 AA.
AC I3K588;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=Syntaxin-binding protein 1 {ECO:0000256|ARBA:ARBA00040519};
DE AltName: Full=Protein unc-18 homolog 1 {ECO:0000256|ARBA:ARBA00042596};
DE AltName: Full=Protein unc-18 homolog A {ECO:0000256|ARBA:ARBA00042593};
GN Name=stxbp1 {ECO:0000313|Ensembl:ENSONIP00000016283.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000016283.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000016283.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the STXBP/unc-18/SEC1 family.
CC {ECO:0000256|ARBA:ARBA00009884}.
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DR AlphaFoldDB; I3K588; -.
DR Ensembl; ENSONIT00000016298.2; ENSONIP00000016283.2; ENSONIG00000012945.2.
DR eggNOG; KOG1300; Eukaryota.
DR GeneTree; ENSGT00940000155127; -.
DR HOGENOM; CLU_009210_2_1_1; -.
DR TreeFam; TF313242; -.
DR Proteomes; UP000005207; Linkage group LG7.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.60; -; 1.
DR Gene3D; 3.40.50.1910; -; 1.
DR Gene3D; 3.40.50.2060; -; 1.
DR InterPro; IPR043154; Sec-1-like_dom1.
DR InterPro; IPR043127; Sec-1-like_dom3a.
DR InterPro; IPR001619; Sec1-like.
DR InterPro; IPR027482; Sec1-like_dom2.
DR InterPro; IPR036045; Sec1-like_sf.
DR PANTHER; PTHR11679:SF35; SYNTAXIN-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR11679; VESICLE PROTEIN SORTING-ASSOCIATED; 1.
DR Pfam; PF00995; Sec1; 1.
DR PIRSF; PIRSF005715; VPS45_Sec1; 1.
DR SUPFAM; SSF56815; Sec1/munc18-like (SM) proteins; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
SQ SEQUENCE 594 AA; 67721 MW; D4A3D482DB434B03 CRC64;
MILTIPGDYI FSSSFLDVAL IVDQLSMRML SSCCKMTDIM TEGITIVEDI MKRREPLPSL
EAIYLITPTE KSVHTLIADF KDPHSSKYKA AHVFFTDSCP DPLFNELVKS RASKVVKTLT
EINIAFLPYE SQVYSLDNPD AFHSFYSPHK TQLKNPVMER LAEQLATLCA TLKEYPAVRY
RGEYKDNATL AQLVQDKLDA YKADDPTMGE GPDKARSQLI ILDRGFDPVS PVLHELTFQA
MGYDLLPIEN DVYKYETSGI GDSREKEVLL HEDDDLWVSL RHKHIAEVSQ EVTRQLKDFS
SSKRMNTGEK VKTTMRDLSQ MLKKMPQYQK ELSKYSTHLQ LAEDCMKHYQ GTVDKLCRVE
QDLAMGTDAE GEKIKDPMRA IVPILLDANV STYDKIRIIL LYIFLKNGIT EENLNKLIQH
AQIPPEDSEI ITNMGHLGVP IITDSTLRRG KKVDRKERVS EQTYQLSRWT PLIKDIMEDA
IDDKLDTKHY PYISTRSSAS FSTTAVSARY GHWHKNKTPG EYRTGPRVMV FIIGGVSFSE
MRCAYEVTQA NGKWEAIIGS THMLTPTKFL KDLQHPDFRE STRVSFEDPD PSAE
//
