ID I3K7A3_ORENI Unreviewed; 752 AA.
AC I3K7A3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Euchromatic histone lysine methyltransferase 2 {ECO:0000313|Ensembl:ENSONIP00000016998.2};
GN Name=ehmt2 {ECO:0000313|Ensembl:ENSONIP00000016998.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000016998.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000016998.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; I3K7A3; -.
DR Ensembl; ENSONIT00000017013.2; ENSONIP00000016998.2; ENSONIG00000013517.2.
DR GeneTree; ENSGT00940000159459; -.
DR HOGENOM; CLU_005790_0_0_1; -.
DR Proteomes; UP000005207; Linkage group LG22.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0002039; F:p53 binding; IEA:InterPro.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd20905; EHMT_ZBD; 1.
DR CDD; cd10533; SET_EHMT2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR043550; EHMT1/EHMT2.
DR InterPro; IPR047762; EHMT_CRR.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR038034; SET_EHMT2.
DR PANTHER; PTHR46307; G9A, ISOFORM B; 1.
DR PANTHER; PTHR46307:SF1; HISTONE-LYSINE N-METHYLTRANSFERASE EHMT2; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF21533; EHMT1-2_CRR; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT REPEAT 227..259
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 260..292
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 291..315
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 325..357
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 358..390
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 391..423
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 513..576
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 579..696
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
SQ SEQUENCE 752 AA; 83166 MW; 6044354CF52EB0D1 CRC64;
MTLMLTVKSQ VKPCPSTFAD GSDAGDTERL EELPLCSCRM EAPRVDSTSH RVSRQCMATE
SIDGELRACT SRTIKGETMR PSSRVPLMVL CDVHRSHMVK HHCCPGCGYF CIAGTFLECC
PDQRIAHRFH RGCVTVLGGG RSRANGGGML FCPHCGEDAS EAQEVTIPSF STASATTVVT
MSASSTTTPS LPPSVPTGPS LTAKLVNYFL LMLMEGIDPT YQPDSQNRRS ALHAAAQRGL
LEVCYMLIQA GAQVDAQDKD LRTPLLEAII NNHVEVARYL VQNGACVYHI DGYTGLHHAA
KLGNLEIVNM LLETGQVDVN AQDSGGWTPI IWAAEHKHVD VIKALLNRGA DVTINDKELN
VCLHWAAYAG NVDIAELVLN AGCSLSSVNV HGDTPLHIAA REGYLECVTL FLSRGADIDI
MNREGDTPLT LARADTPVWV SLQINRKLRR GITNRMLRTE RIICSDIAQG YENVPIPCVN
AVDDEGCPSD YKYVSENCET SAMNIDRNIT HLQHCSCTDD CSSSNCLCGQ LSIRCWYDKD
QRLLQEFNKI EPPLIFECNM ACSCYRTCKN RVVQAGIKVR LQLYRTEKMG WGVRALQDIP
QGSFICEYVG ELISDAEADV REDDSYLFDL DNKDGEVYCI DARYYGNISR FINHLCDPNL
IPVRVFMLHQ DLRFPRIAFF SSRDILSGQE LGFDYGDRFW DIKSKYFTCQ CGSEKCKHSA
EAIALEQSRL TLTHGAFGLT PSVAHTSNGN TS
//
