ID I3K943_ORENI Unreviewed; 408 AA.
AC I3K943;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=ANTXR cell adhesion molecule 2 {ECO:0000313|Ensembl:ENSONIP00000017638.2};
GN Name=antxr2 {ECO:0000313|Ensembl:ENSONIP00000017638.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000017638.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000017638.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the ATR family. {ECO:0000256|ARBA:ARBA00008095}.
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DR AlphaFoldDB; I3K943; -.
DR STRING; 8128.ENSONIP00000029819; -.
DR Ensembl; ENSONIT00000017653.2; ENSONIP00000017638.2; ENSONIG00000014031.2.
DR eggNOG; ENOG502QT7Y; Eukaryota.
DR GeneTree; ENSGT00940000156320; -.
DR HOGENOM; CLU_029760_0_0_1; -.
DR TreeFam; TF328943; -.
DR Proteomes; UP000005207; Linkage group LG12.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR017360; Anthrax_toxin_rcpt.
DR InterPro; IPR008399; Anthrax_toxin_rcpt_C.
DR InterPro; IPR008400; Anthrax_toxin_rcpt_extracel.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR16059; ANTHRAX TOXIN RECEPTOR; 1.
DR PANTHER; PTHR16059:SF13; ANTHRAX TOXIN RECEPTOR 2; 1.
DR Pfam; PF05586; Ant_C; 1.
DR Pfam; PF05587; Anth_Ig; 1.
DR Pfam; PF00092; VWA; 1.
DR PIRSF; PIRSF038023; Anthrax_toxin_receptor_2; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR038023-1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 240..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..135
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT BINDING 41
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /evidence="ECO:0000256|PIRSR:PIRSR038023-1"
SQ SEQUENCE 408 AA; 45390 MW; 7CC12D868AA29DC7 CRC64;
MRVSFIVFSG QAKILLPLTG ERHKIEEGLR LLKDVTPAGE TYMHKGIEQA TEQIQQQSVK
SSSIILALTD GKLAVYVHEL TVKQADKARK YGARVYCVGI KEFDEQQLAE IADTKDHVFP
VKDGFHALKS IVNSILKRSC TEILSVEPSS VCVNQSFDIV LRGNGFALGR SNEGVVCSFI
IGQQTFTEKP STVRNDYLMC PAPKLYEVGQ TMDVLISLNN GKSFISSAYT ISATTCSDGF
VVAIVFLVLF LLVALALMWW FWPLCCKVVS AATQPITSTE PEPLPKKKWP TVDASYYGGR
GAGGISRMEV RWGEKGSTEE GARLEKAKNA KVSIPEDVEE PMIKRPTPKP APNRPPENKW
YTPIKGRLDA LWALLRRQYD RVSLMRPTSE DQVSQNSSLM FFSDLKQT
//
