ID I3KAX9_ORENI Unreviewed; 470 AA.
AC I3KAX9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 24-JAN-2024, entry version 62.
DE SubName: Full=Ubiquitin-conjugating enzyme E2 variant 3 {ECO:0000313|Ensembl:ENSONIP00000018274.1};
GN Name=LOC100696066 {ECO:0000313|Ensembl:ENSONIP00000018274.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000018274.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000018274.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR RefSeq; XP_003440413.1; XM_003440365.4.
DR AlphaFoldDB; I3KAX9; -.
DR STRING; 8128.ENSONIP00000018274; -.
DR Ensembl; ENSONIT00000018291.2; ENSONIP00000018274.1; ENSONIG00000014522.2.
DR GeneID; 100696066; -.
DR KEGG; onl:100696066; -.
DR CTD; 55293; -.
DR eggNOG; KOG1495; Eukaryota.
DR eggNOG; KOG2391; Eukaryota.
DR GeneTree; ENSGT00940000153903; -.
DR HOGENOM; CLU_039842_0_1_1; -.
DR InParanoid; I3KAX9; -.
DR OMA; GIAVGKH; -.
DR OrthoDB; 5344346at2759; -.
DR TreeFam; TF314963; -.
DR Proteomes; UP000005207; Linkage group LG7.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:InterPro.
DR Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR001557; L-lactate/malate_DH.
DR InterPro; IPR022383; Lactate/malate_DH_C.
DR InterPro; IPR001236; Lactate/malate_DH_N.
DR InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR InterPro; IPR008883; UEV_N.
DR PANTHER; PTHR43128; L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)); 1.
DR PANTHER; PTHR43128:SF32; UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 3-LIKE; 1.
DR Pfam; PF02866; Ldh_1_C; 1.
DR Pfam; PF00056; Ldh_1_N; 1.
DR Pfam; PF05743; UEV; 1.
DR PRINTS; PR00086; LLDHDRGNASE.
DR SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS51322; UEV; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 2..145
FT /note="UEV"
FT /evidence="ECO:0000259|PROSITE:PS51322"
SQ SEQUENCE 470 AA; 51211 MW; 266D3539B4E31184 CRC64;
MDLTSEKIQR ILSKYKFRDV AVEELEKIHR IYPGMKPSTG TYTFSDSTQK DLLKLTGTIP
VQYEGRSYNF PIQLWLLDSF PFTPPICHLK PTSNMVIREG KHVDARGRIH LPGLHNWDYP
KSSVVGLLNE MVTKFQEDPP LSSKTTPDNK DPHELLAFVS NFRISDGGIG HHDQPINKVS
VIGGGDLGMA SVMSILSKCK VDKLVFIDVA ESSTKGGSTD LEIFSLPKVE VSRDISASAG
SRVVVVTANA WSSEQSYVTV VQTNVDLYRG IIPNLARLSP SAVMLIASQP VDIMTHVAWR
QSGLPPTHVI GAGCNLDSER LSHVMDINLN THKPAWVIGE LSDNKIPVMS NSGLNSNASP
EIAQGSSSTK PLLDRAFEIM KNRGQRSWSV GLSIADITNS VLTDKKVVHS VSTLAQGWGG
IAVEVFLSLP CIMGVNGSTR LAGVSLGQQE DSKLRNSVTS LSSLMAQLRI
//