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Database: UniProt
Entry: I3KAX9_ORENI
LinkDB: I3KAX9_ORENI
Original site: I3KAX9_ORENI 
ID   I3KAX9_ORENI            Unreviewed;       470 AA.
AC   I3KAX9;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   24-JAN-2024, entry version 62.
DE   SubName: Full=Ubiquitin-conjugating enzyme E2 variant 3 {ECO:0000313|Ensembl:ENSONIP00000018274.1};
GN   Name=LOC100696066 {ECO:0000313|Ensembl:ENSONIP00000018274.1};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000018274.1, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000018274.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   RefSeq; XP_003440413.1; XM_003440365.4.
DR   AlphaFoldDB; I3KAX9; -.
DR   STRING; 8128.ENSONIP00000018274; -.
DR   Ensembl; ENSONIT00000018291.2; ENSONIP00000018274.1; ENSONIG00000014522.2.
DR   GeneID; 100696066; -.
DR   KEGG; onl:100696066; -.
DR   CTD; 55293; -.
DR   eggNOG; KOG1495; Eukaryota.
DR   eggNOG; KOG2391; Eukaryota.
DR   GeneTree; ENSGT00940000153903; -.
DR   HOGENOM; CLU_039842_0_1_1; -.
DR   InParanoid; I3KAX9; -.
DR   OMA; GIAVGKH; -.
DR   OrthoDB; 5344346at2759; -.
DR   TreeFam; TF314963; -.
DR   Proteomes; UP000005207; Linkage group LG7.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
DR   GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:InterPro.
DR   Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR   InterPro; IPR001557; L-lactate/malate_DH.
DR   InterPro; IPR022383; Lactate/malate_DH_C.
DR   InterPro; IPR001236; Lactate/malate_DH_N.
DR   InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   InterPro; IPR008883; UEV_N.
DR   PANTHER; PTHR43128; L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+)); 1.
DR   PANTHER; PTHR43128:SF32; UBIQUITIN-CONJUGATING ENZYME E2 VARIANT 3-LIKE; 1.
DR   Pfam; PF02866; Ldh_1_C; 1.
DR   Pfam; PF00056; Ldh_1_N; 1.
DR   Pfam; PF05743; UEV; 1.
DR   PRINTS; PR00086; LLDHDRGNASE.
DR   SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF54495; UBC-like; 1.
DR   PROSITE; PS51322; UEV; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          2..145
FT                   /note="UEV"
FT                   /evidence="ECO:0000259|PROSITE:PS51322"
SQ   SEQUENCE   470 AA;  51211 MW;  266D3539B4E31184 CRC64;
     MDLTSEKIQR ILSKYKFRDV AVEELEKIHR IYPGMKPSTG TYTFSDSTQK DLLKLTGTIP
     VQYEGRSYNF PIQLWLLDSF PFTPPICHLK PTSNMVIREG KHVDARGRIH LPGLHNWDYP
     KSSVVGLLNE MVTKFQEDPP LSSKTTPDNK DPHELLAFVS NFRISDGGIG HHDQPINKVS
     VIGGGDLGMA SVMSILSKCK VDKLVFIDVA ESSTKGGSTD LEIFSLPKVE VSRDISASAG
     SRVVVVTANA WSSEQSYVTV VQTNVDLYRG IIPNLARLSP SAVMLIASQP VDIMTHVAWR
     QSGLPPTHVI GAGCNLDSER LSHVMDINLN THKPAWVIGE LSDNKIPVMS NSGLNSNASP
     EIAQGSSSTK PLLDRAFEIM KNRGQRSWSV GLSIADITNS VLTDKKVVHS VSTLAQGWGG
     IAVEVFLSLP CIMGVNGSTR LAGVSLGQQE DSKLRNSVTS LSSLMAQLRI
//
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