ID I3KCP1_ORENI Unreviewed; 1613 AA.
AC I3KCP1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Pappalysin 1 {ECO:0000313|Ensembl:ENSONIP00000018886.2};
GN Name=pappa {ECO:0000313|Ensembl:ENSONIP00000018886.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000018886.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000018886.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase M43B family.
CC {ECO:0000256|ARBA:ARBA00008721}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR STRING; 8128.ENSONIP00000054647; -.
DR Ensembl; ENSONIT00000018903.2; ENSONIP00000018886.2; ENSONIG00000015000.2.
DR eggNOG; ENOG502QQ7Z; Eukaryota.
DR GeneTree; ENSGT00940000156654; -.
DR HOGENOM; CLU_002636_2_0_1; -.
DR TreeFam; TF331636; -.
DR Proteomes; UP000005207; Linkage group LG7.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR CDD; cd00033; CCP; 4.
DR CDD; cd04275; ZnMc_pappalysin_like; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 3.40.390.10; Collagenase (Catalytic Domain); 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 4.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR006558; LamG-like.
DR InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR InterPro; IPR011936; Myxo_disulph_rpt.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR043543; PAPPA/PAPPA2.
DR InterPro; IPR008754; Peptidase_M43.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR NCBIfam; TIGR02232; myxo_disulf_rpt; 1.
DR PANTHER; PTHR46130; LAMGL DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46130:SF2; PAPPALYSIN-1; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF05572; Peptidase_M43; 1.
DR Pfam; PF00084; Sushi; 2.
DR SMART; SM00032; CCP; 4.
DR SMART; SM00560; LamGL; 1.
DR SMART; SM00004; NL; 3.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
DR PROSITE; PS50923; SUSHI; 3.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1613
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025554567"
FT DOMAIN 1204..1275
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1276..1337
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1403..1458
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 69..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1613 AA; 181283 MW; F07D20DE757D40C5 CRC64;
MKLWTSPWVS CLVILILCFG SECGIVRKKG RSKRELVRIR EAKATIPGAC ATRLPRGKRS
LPGLERRVLR QRRRSSQAEG NSPDRGKAVY FTGRGDQLRL KPGVEIPRGN FTLEMWIKPE
GGQRSPTVIA GLYDKCFYAS SDRGWLLGIQ ADSEYGDRDP RFFFSLKTDR AHKVTSIRSN
ARYIPNQWAH IAITYDGVYM KLFVNGAQVA VSREQSGDVF SHLTQKCKVL MIGGNALNHN
YRGAVERVSL WREARGQRHI IRDMQGHEDP QDLPKLIIRE TFEHPGRKWL TVKDGSFPQP
EHRGGGLLDT SLEPPTCGQT VCDNVEVIQN YNQLWTFRRP KKVRYRVVNI WDDARTRPTV
SDHQIILQHQ QLNDAFSPYN ITWELSIHNV TNSSLRNRLI LANCDISKIG DDQCDLECNH
PLTGFDAGDC MSRYRTRCPE HKQGNGICDP ECNWENFFYD LGDCCNPNVT DVTKTCFNRS
SPHKAYLDMK ELKEILQLDG STHLNVFFAN SSDEDLAGVA TWPWDKEALT HLGGIVLNPS
FYGTFGHTDT MVHEIGHSLG LYHVFRGVSE TESCNDACLE TEPSMETGDL CADTKPTSKY
KGCSDPEPGN DTCGIRHFTH TPFNNYMSYA DDACTDSFTM NQVARMHCYL DLIYQTWQPA
SKPPLVPMAP QVVEQHHNSI TLEWFPPISG QFYDREVGSV CDKCTEGRVL LQYASNSSSP
RPCDPSGHWS PREAEGPPDV EQACEPSVRT WSPHSATEQD IVGLPECPSQ GCMLQLEFAY
PLVPDSLTVW VTFLSREETA LPAIHNILLL TVSGNNISLG PSNVFCDTPL TMKLDIEEEV
YGVQFYTMEQ HLEIDATLLT SKPNYKLCNH CQPLRYRLLR QPPFTHAPNG LLLNEPTRRY
TDRDVIPHVT YTYQVQTISS QSESEPSPPL VHQLGAPYCG DGRIQSSKGE ECDDMNSMNG
DGCSSQCKKE PFFNCVEEPS MCYYYDGDGV CEDFERETGV RDCGLYTPSG FLDQWASSIE
VSHEEKPYCS GEVAAGYPAV TKTCQSKVFD LSDGVSQYAW FPCRVADSAW GYYTYWLKAH
FSHPMVAAAV IIHLAADGTG FIDQTQCNIT VQLVDTKEGI HSLGEWRLSC RTNPLVIPVS
HDLSVAFYHT KAILVMFSSH LVAISGVALR SFQSFDPITI SGCQSNEIYN PTGQSCVHYS
CEAIDCQEPL IRNAELKCSS PGHHFYNGDR CTISCNSGYV LQVHQDDDII KSQSETSVTI
TCANGKWNKQ VSCEPVDCGL PDKYHVHPAI FSFPEGTTYG RKSTFQCREP AQLMGTNNTL
TCLEDGLWSF PEALCELRCP APPLVPNAVL QTKRCQQSDL KVGTLCKYKC RPGYHVTNKP
KRRAFKRQCT EDGTWLEGSC EPVTCDPPPP IFHGSYNCTN GFRFDSTCTL NCSDPAGSNE
IRCRKDGNWT GSFRLCPHSQ GQCSLPQNLH YSLQYSCKRG HGIGEDCELT CREGNNDVVI
LPHNMTVEKV MKEHWRNPPK VKSIICTMGL KWYPHPEFLH CIKGCEPFMG DNYCDSVNNR
AFCNYDGGDC CQSTVKTKKV IPFPMSCDLR DECSCRDPNA VENRKDEHVH SLG
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