ID I3KD96_ORENI Unreviewed; 822 AA.
AC I3KD96;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Rho guanine nucleotide exchange factor (GEF) 7b {ECO:0000313|Ensembl:ENSONIP00000019091.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000019091.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000019091.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}.
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DR AlphaFoldDB; I3KD96; -.
DR STRING; 8128.ENSONIP00000056826; -.
DR Ensembl; ENSONIT00000019108.2; ENSONIP00000019091.2; ENSONIG00000015169.2.
DR GeneTree; ENSGT00940000155360; -.
DR Proteomes; UP000005207; Linkage group LG23.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01225; PH_Cool_Pix; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd11877; SH3_PIX; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR032409; GEF6/7_CC.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR046376; PH_Cool_Pix.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46026:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 7; 1.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF16523; betaPIX_CC; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16615; RhoGEF67_u1; 1.
DR Pfam; PF16614; RhoGEF67_u2; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00033; CH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..111
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 161..220
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 245..425
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 447..552
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 567..588
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 646..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 784..811
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 822 AA; 92530 MW; 0BA7FC6CA38BE16D CRC64;
MNSAEQTVTW LITLGVLESP KKSISDPEAF LQASLQDGAV LCRLLERLRP GTVDKFFQEP
RSDSECQRNI TEFVKGCGAF GVEPFEVNDL LQGLNFSKVL NSLVALNKAT EDLSVSGDTV
CVAHSSTSRI KSFDSLNTQS RSLKLVQPQY RSLDMSEGSG CGQLLVRARF PFQQTNEDEL
SFSKGDLIIV TRQEEGGWWE GTLKDKTGWF PSNYVRELKG NDKPKSGTLK SPPKGFDTTI
INKTYYNVVL QNILEAETEY SRELQSLLGS YLRPLHPTDR LSSVDIGHIQ ANLEDISTFQ
QMLVQSLEEH TRLPESQQRI GGFFLGLIPQ MKKIYLTYCS NHPSAVNVLT QHSEELKEYM
ESKGAPPPGI LALTTSLSKP FIRLDRYPTL LKELDRHMED QHPDRADLQA SMTAFKNLSA
QCKEIRKKKE LVLQILTEPI RNWEGDDIRT LGPVLHMSQA AVRSQNCQES NECYLLLFHH
TLLMVSASLR MSGFIYQGRI PLSGMLISRI EDGENLKNAF EISGSQGERI QVACNSQHDL
QEWLDLLTKH THAPAASTHK TLSVCHTLPS HPVTPSRNSE SRGGSSVNTY HTLPHVSLHG
ISSPMWGPLE PPSTPKPWSL SCLRPAPPLR PSAALCYKED MSKSPKNVKK LLPKRKPERK
PSEEDFTVRK STAALEEDAQ ILKVIEAYCT SAKTRQTLNS TWQGTDLMHN HVLADNSLTV
AGLPGNPPCS DQSEDSDYDS IWTAHSYRTA SFSRSSRKDV QVLFPEEEKI IVEEMRSNGQ
TVVEERMKRT LEEEQRARKE LERIVRRVLK NMNDPTWDET NL
//
