ID   I3KE06_ORENI            Unreviewed;       661 AA.
AC   I3KE06;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 67.
DE   SubName: Full=Semaphorin 7A (John Milton Hagen blood group) {ECO:0000313|Ensembl:ENSONIP00000019351.2};
GN   Name=sema7a {ECO:0000313|Ensembl:ENSONIP00000019351.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000019351.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000019351.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the semaphorin family.
CC       {ECO:0000256|ARBA:ARBA00009492}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR   RefSeq; XP_005470750.1; XM_005470693.3.
DR   AlphaFoldDB; I3KE06; -.
DR   STRING; 8128.ENSONIP00000019351; -.
DR   Ensembl; ENSONIT00000019368.2; ENSONIP00000019351.2; ENSONIG00000015382.2.
DR   GeneID; 100704136; -.
DR   KEGG; onl:100704136; -.
DR   CTD; 8482; -.
DR   eggNOG; KOG3611; Eukaryota.
DR   GeneTree; ENSGT00940000158358; -.
DR   HOGENOM; CLU_009051_11_2_1; -.
DR   InParanoid; I3KE06; -.
DR   OMA; DSYHAEY; -.
DR   OrthoDB; 5361423at2759; -.
DR   TreeFam; TF352628; -.
DR   Proteomes; UP000005207; Linkage group LG7.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR   GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR027231; Semaphorin.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR11036; SEMAPHORIN; 1.
DR   PANTHER; PTHR11036:SF80; SEMAPHORIN-7A; 1.
DR   Pfam; PF01437; PSI; 1.
DR   Pfam; PF01403; Sema; 1.
DR   SMART; SM00423; PSI; 1.
DR   SMART; SM00630; Sema; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   SUPFAM; SSF103575; Plexin repeat; 1.
DR   SUPFAM; SSF101912; Sema domain; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..32
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           33..661
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5025664516"
FT   DOMAIN          38..475
FT                   /note="Sema"
FT                   /evidence="ECO:0000259|PROSITE:PS51004"
FT   DOMAIN          539..605
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
SQ   SEQUENCE   661 AA;  75311 MW;  4212A3A7B286B723 CRC64;
     MDCRTAEQLR RNMRRFVFSL FWLVGDLQLA LSAGLKDTPT LGSKNTPRLL SKDILSVGLE
     YQINQNHSVL FYEEGSDELY LGGNDFILKL NVDDFHIIEK FHLNATGQEE CQEDPCENVI
     TVIEKFQNDL FVCGTNGQKP ECWQLRPSVN NQSLEIFDSR DGTGISPFIY TQNSLSLTVE
     GDLYAAAPLD ADGSTLQFRR KAGRRTNVWM YDSWVSEPTF VSASWVQRKD DPDNEKIYVF
     FREKNSDHNR EVDPLISRVA RVCKVDEGGS KRFFQNMWTS FLKARLVCGI PKESLYFNRL
     QDVYVMHADN WQDTKVYALF TSNWNSTAVC IYTIKMIENI FENSNFKGYN ANIPTPRPGT
     CSKNSKSLPR DTVNIVKDHS EMADWVDSDP FYISTNNYTK IVVDRVQAAD QRFYNILLLA
     TDSGKIHKVL ESGSEPFIIS ETQLSNSSII QSMKLDSKKK TLIVGFAERI TAVNLQSCQE
     YSKSCEECVL ARDPYCAWTN DGCTSTVPGS IQNIVDGKTN VCNLTVKALR NRTKREIRPL
     SSVHLRTVHS LPQGVPFYLS CPIDSYHAEY TWEQKGQKSP CLQMLTNCLH LIPSMSQENY
     GTYRCISKEK DYIKVVGTYE LIENQEPKKC SKSNTPDNWN AAPALIPEMI WITLLVAIIS
     F
//