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Database: UniProt
Entry: I3KG21_ORENI
LinkDB: I3KG21_ORENI
Original site: I3KG21_ORENI 
ID   I3KG21_ORENI            Unreviewed;      1468 AA.
AC   I3KG21;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   24-JAN-2024, entry version 74.
DE   SubName: Full=Neurexin-1a {ECO:0000313|Ensembl:ENSONIP00000020066.2};
GN   Name=LOC100697588 {ECO:0000313|Ensembl:ENSONIP00000020066.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000020066.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000020066.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the neurexin family.
CC       {ECO:0000256|ARBA:ARBA00010241}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   RefSeq; XP_013124981.1; XM_013269527.2.
DR   STRING; 8128.ENSONIP00000058773; -.
DR   Ensembl; ENSONIT00000020083.2; ENSONIP00000020066.2; ENSONIG00000015930.2.
DR   GeneID; 100697588; -.
DR   KEGG; onl:100697588; -.
DR   CTD; 565531; -.
DR   eggNOG; KOG3514; Eukaryota.
DR   GeneTree; ENSGT00940000154292; -.
DR   HOGENOM; CLU_001710_0_1_1; -.
DR   OrthoDB; 2999458at2759; -.
DR   TreeFam; TF321302; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR   CDD; cd00053; EGF; 1.
DR   CDD; cd00054; EGF_CA; 1.
DR   CDD; cd00110; LamG; 6.
DR   Gene3D; 2.60.120.200; -; 6.
DR   Gene3D; 2.10.25.10; Laminin; 3.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR003585; Neurexin-like.
DR   InterPro; IPR027789; Syndecan/Neurexin_dom.
DR   PANTHER; PTHR15036:SF82; -; 1.
DR   PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR   Pfam; PF00008; EGF; 1.
DR   Pfam; PF02210; Laminin_G_2; 6.
DR   Pfam; PF01034; Syndecan; 1.
DR   SMART; SM00294; 4.1m; 1.
DR   SMART; SM00181; EGF; 3.
DR   SMART; SM00282; LamG; 6.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 6.
DR   PROSITE; PS50026; EGF_3; 3.
DR   PROSITE; PS50025; LAM_G_DOMAIN; 6.
PE   3: Inferred from homology;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..1468
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5025642179"
FT   TRANSMEM        1395..1415
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          32..209
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|PROSITE:PS50025"
FT   DOMAIN          205..243
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          250..440
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|PROSITE:PS50025"
FT   DOMAIN          447..641
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|PROSITE:PS50025"
FT   DOMAIN          645..682
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          687..860
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|PROSITE:PS50025"
FT   DOMAIN          874..1049
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|PROSITE:PS50025"
FT   DOMAIN          1052..1089
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50026"
FT   DOMAIN          1093..1294
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|PROSITE:PS50025"
FT   REGION          1299..1385
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1435..1468
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1299..1347
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1452..1468
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1468 AA;  160872 MW;  8113E2F85014CEDD CRC64;
     MSVMAVCVWA AAPLLFLGLC LCSVGGQAQG EVLEFGGVSS QWGRFPVWNA CCESVLSFSL
     RTHSQEGLLL YLDDEGFCDF LELLLLHGHL RLRFSIFCAE PAELQSGVAV SDGRWHAVRV
     KRDWRNTSLE VDGRLEGWAE VKSKRRDMTV FSHTYMGGVS PELHSSPLRL TSPSVREHPA
     FRGWITAVSI NGSLVTLDSS EGVTVTAGCG PDHQCQNGGV CNVVNDQAVC DCSDTGYQGN
     DCSEAREEYV ATFKGSEYFC YDLSPNPIQS SSDEITLSFK TLQRNGLMLH TGKSADYVNL
     ALKNGAVSLV INLGSGAFEA LVEPVNGKFN DNAWHDVKVT RNLRQHSGIG HAMVTISVDG
     ILTTTGYTQE DYTMLGSDDF FYVGGSPSTA DLPGSPVSNN FMGCLKEVVY KNNDVRLELS
     RLAKQGDPKM KVSGVVSFKC ESVATLDPVT FDTPESYVAL SKWTAKKAGS ISFDFRTTEP
     NGLMLFSHGK PRQQQRKDPR TPPTVKVDFF AIEMLDGHLY LLLDMGSGTT KTKAIDRKVN
     DGEWYHVDFQ RDGRSGTISV NSVRTAYTAP GDSEILDLDD TLYLGGLPED RAGLIFPTEV
     WTALLNYGYV GCIRDLFVDG QSKDIRRLAE AQRAVGVKPS CSREPPKQCL SNPCQHNGIC
     REGWNRYVCD CSGTGYLGRS CERDATILSY DGSKFMKVQL PVVMHTEAED VSLRFRSQRA
     YGVLMATTSR NSADTLRLEL DGARVRLTVN LDCIRINCTA SKGPETIFAG SSLNDNEWHT
     VRVVRRGKSL KLTVDDLQPV EGQMAGDHTQ LEFHNVETGI VTEKRFMPAV PSNFIGHLQG
     LTLNGMPYID LCKNGDIDYC ELNAVIGYKS IVADPVTFRS RSSFVTLPTL QAYYSMHLFM
     QFKTTSPDGL ILFNRGDGND FIVVELVKGY LHYISDLGNG AHLIKGNSNS PLNDNHWHNV
     HISRDTNNLH TVKIDTKVTT QTTMGAKNLD LKGDLYIGGV SKEMYRDLPK LVHSREGFQG
     CLATVDLNGR LPDLLADALA TMGQVERGCE GPSTTCQEDS CSNQGVCLQQ WEGFTCDCSM
     TSYAGPLCND AGTTYIFGRD GGLVIYTWPP NERPSTRADR LSLGFSTQQK HAILLRVDSA
     SGLGDYLQLQ IDKGNIRVVF NVGTDDINIE ESSKFVNDGK YHVIRFTRSG GNATLQLDDL
     PVIERYPSGN IDNERLAIAR QRIPYRLGRV VDDWLLDKGR QLTIFNSQTT VRVGGGERGA
     AMFQGQLAGL YYNGLRILNM AAEGHPHIKV EGSARLVGDM PSSSITPQSS AAAGGNRSDS
     APSISDITTT TATNRKQGGT TKSSDDLLVA SAECPSDDED IDPCDPSSAR PPLPEVKMFP
     GPSEVVRESS STTGMVVGIV AAAALCILIL LYAMYKYRNR DEGSYHVDES RNYISNSATQ
     PNGSAKDKPL GIAKISKNKK NKDKEYYV
//
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