ID I3KJ08_ORENI Unreviewed; 336 AA.
AC I3KJ08;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Secreted frizzled-related protein 2 {ECO:0000313|Ensembl:ENSONIP00000021103.1};
GN Name=LOC100706032 {ECO:0000313|Ensembl:ENSONIP00000021103.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000021103.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000021103.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR RefSeq; XP_003449368.1; XM_003449320.4.
DR AlphaFoldDB; I3KJ08; -.
DR STRING; 8128.ENSONIP00000021103; -.
DR MEROPS; I93.002; -.
DR Ensembl; ENSONIT00000021122.2; ENSONIP00000021103.1; ENSONIG00000016751.2.
DR GeneID; 100706032; -.
DR KEGG; onl:100706032; -.
DR CTD; 100538205; -.
DR eggNOG; KOG3577; Eukaryota.
DR GeneTree; ENSGT00940000156432; -.
DR InParanoid; I3KJ08; -.
DR OMA; VSKLCHR; -.
DR OrthoDB; 4814466at2759; -.
DR TreeFam; TF350133; -.
DR Proteomes; UP000005207; Linkage group LG14.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR001134; Netrin_domain.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF128; SECRETED FRIZZLED-RELATED PROTEIN 2-LIKE; 1.
DR Pfam; PF01392; Fz; 1.
DR SMART; SM00063; FRI; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090}; Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..336
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003673865"
FT DOMAIN 32..152
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 176..333
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 47..93
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 84..122
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 115..139
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 336 AA; 37035 MW; A1D018A7855EFFA1 CRC64;
MPVFLLSFIA LFGVSHASDS APPEPSLWFK PTFRSVCKPI PSTMSLCHGI GYRSMWIPNM
LGHDSLREVQ QQSAAWLPLI SKHCHRDTKK FLCSLFAPVC LPEVSGPVSP CRNLCEAVRD
GCVPVMSAFG FPWPYMFNCT RFPHGTELCI PVSEEQDGRE TEEAKHEEVP KGSVICEACS
LAAEGEIDIQ ENFCHSPYAF KMRLGSMMTV GGDLQLVPTA RSRILRWAGG GAEKAEGVGG
AMAHSALWLQ EGGTCTCPGL DSAESDENEE KSQEVVQMDK KVTKRGKKVG KGGWYLSLAQ
AEEGRLVLTR LVRWSRGDKE LKKFIRALLK QPCAEL
//
