ID   I3KJ32_ORENI            Unreviewed;       581 AA.
AC   I3KJ32;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=Melanophilin {ECO:0000313|Ensembl:ENSONIP00000021127.2};
GN   Name=MLPH {ECO:0000313|Ensembl:ENSONIP00000021127.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000021127.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000021127.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; I3KJ32; -.
DR   STRING; 8128.ENSONIP00000021128; -.
DR   Ensembl; ENSONIT00000021146.2; ENSONIP00000021127.2; ENSONIG00000016771.2.
DR   eggNOG; ENOG502RJPZ; Eukaryota.
DR   GeneTree; ENSGT00950000183138; -.
DR   HOGENOM; CLU_025193_2_0_1; -.
DR   TreeFam; TF331599; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   CDD; cd15752; FYVE_SlaC2-a; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR041282; FYVE_2.
DR   InterPro; IPR037442; Melanophilin_FYVE-rel_dom.
DR   InterPro; IPR006788; Myrip/Melanophilin.
DR   InterPro; IPR010911; Rab_BD.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR14555:SF1; MELANOPHILIN; 1.
DR   PANTHER; PTHR14555; MYELIN-ASSOCIATED OLIGODENDROCYTIC BASIC PROTEIN MOBP -RELATED; 1.
DR   Pfam; PF02318; FYVE_2; 1.
DR   Pfam; PF04698; Rab_eff_C; 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR   PROSITE; PS50916; RABBD; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          9..129
FT                   /note="RabBD"
FT                   /evidence="ECO:0000259|PROSITE:PS50916"
FT   REGION          348..368
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          389..473
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          482..516
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        389..407
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        440..454
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        455..470
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   581 AA;  65764 MW;  7AFBE7C42E48B938 CRC64;
     MPGSTAGKKL DLSKLTDEEA QHVWEVVQRD FDLRKKEEDR LGDLKTKVER EDTKKELLGN
     QTSLTESHCI RCLQPFKFLL NNKQQCLDCQ LYICKSCSRY NKKEDGWVCD ACHMTRVLKI
     GTLEWYHENV RARFKRFGSA KVMRSLFRRF DGERSRSQSD LGEPHEYDTQ SMPEVHSAYE
     EHSMDATDSQ QHQRAPGDPD IMVMDVGGRE SMLAEADMAT VFHQIMDEQH KELDLEITPQ
     QDDLVYSDSR TIPSRSISRL SYSSCGSGSI GGPRCSSSIY LPGLEDSEEE EEDEHCQPYP
     FYQSHSGLFR QTSQDSLSSA NHPPQITDIN RRMSAIETLL NRLEQKVTST YDQTSPTPSS
     TSPLPQWNEV DLEEQQLRQR LHEMTDNISD HSLTSDDEDE PERPHSSQEI LAWRSPQADP
     RPSKLPIRPT SRASIVVSRL EEEQPQQTES LKTNDSSESL ERKGHPLEEG SKASFKGSTA
     LLVELEDKVA QAAANVQNAQ SEVSDIESRI AALNAAGMSS DKKRKSAIPI QARRLSHNFP
     TNQVDRFTRN SLYRGSLTQR NPVAKAKTRA ACAKPVMTQG S
//