ID I3KKG7_ORENI Unreviewed; 780 AA.
AC I3KKG7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Frizzled-3 {ECO:0000313|Ensembl:ENSONIP00000021612.1};
GN Name=LOC100702483 {ECO:0000313|Ensembl:ENSONIP00000021612.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000021612.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000021612.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_005459025.1; XM_005458968.3.
DR RefSeq; XP_019215217.1; XM_019359672.1.
DR AlphaFoldDB; I3KKG7; -.
DR STRING; 8128.ENSONIP00000021612; -.
DR Ensembl; ENSONIT00000021631.2; ENSONIP00000021612.1; ENSONIG00000017139.2.
DR GeneID; 100702483; -.
DR KEGG; onl:100702483; -.
DR eggNOG; KOG3577; Eukaryota.
DR GeneTree; ENSGT00940000156491; -.
DR HOGENOM; CLU_007873_4_1_1; -.
DR InParanoid; I3KKG7; -.
DR OMA; PFLWISH; -.
DR OrthoDB; 5483535at2759; -.
DR TreeFam; TF317907; -.
DR Proteomes; UP000005207; Linkage group LG1.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF22; FRIZZLED-3; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..780
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003673926"
FT TRANSMEM 92..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 334..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 384..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 466..493
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 513..538
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 572..594
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 119..232
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 295..602
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 628..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..662
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..696
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..725
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 124..185
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 132..178
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 199..223
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 780 AA; 88391 MW; 81082703ABD75A2C CRC64;
MQSGCTGAYP FLWISHSLMW IYCFSTTTGT KNGPNSFTGC LYNGLLHYNI IALRGGEMSK
FKMQTPLGRG YVRDTFPKTV TTDCRLRFPI HYFFMPVFLL VFSLVTPAYS IHVESIESHS
EFTCEPIRLR MCQDLPYNTT FMPNLLNHYD QQTAALAMEP FHPMVNLVCS ADLRMFLCAL
YAPVCTVYGH VSMPCRSLCQ RAKDECHKLM EIFGVAWPDD MECSRFPDCD EPYPRAEDLL
TGSEPTDQSS MTVQRDYGFW CPRELKVDPD LGYTFMGRKD CSAPCPSMFF NQQELTFIRY
FIGVVSIVCL SATLFTFLTF LIDVTRFRYP ERPIIFYAVC YVMVSLVFFL GFLLEGRVAC
NPVSPSQFRA STITQGSHNK ACTLFFMVLY FFTMAGSVWW VILTITWFLA AVPKWGSEAI
EKKALLFHAI AWGLPGALTV TLLALNKIEG DGISGVCFIG LYDIDALRWF VLAPLCVNVA
VGVSLLLVGI VALNRVRMEI PLEKENQTKL VKFMIRMGVF SVLYLAPLFT VIGCYIYEHT
YRKIWEKTWM ENNCRRYHIP CPYKVEETSR PAMVLFLIKY LMMLVVGIPS VFWVGSKKTC
FEWASFLHGR RRKDSGVNES RQVLQEQPDF AQSLLREPNT PIVRKSRGTS TQGTSTHASS
THLAVLDDLD EPVRTHHGHP SSTRSKASSV HSKASYHGSL RRTRDDRSDT VVYRGTEDRS
FHGSNPRLDH PLSTHSSLHQ IDSHSRHSSQ RDVSEAPPTL ITHGTTASDG RAAENEGTSA
//
