ID I3KKU7_ORENI Unreviewed; 612 AA.
AC I3KKU7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 24-JAN-2024, entry version 66.
DE SubName: Full=ATG16 autophagy related 16-like 1 (S. cerevisiae) {ECO:0000313|Ensembl:ENSONIP00000021742.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000021742.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000021742.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat ATG16 family.
CC {ECO:0000256|ARBA:ARBA00009271}.
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DR AlphaFoldDB; I3KKU7; -.
DR STRING; 8128.ENSONIP00000021742; -.
DR Ensembl; ENSONIT00000021761.2; ENSONIP00000021742.2; ENSONIG00000017239.2.
DR eggNOG; KOG0288; Eukaryota.
DR GeneTree; ENSGT00940000153936; -.
DR HOGENOM; CLU_000288_57_10_1; -.
DR InParanoid; I3KKU7; -.
DR OMA; GRPCISP; -.
DR TreeFam; TF315541; -.
DR Proteomes; UP000005207; Linkage group LG14.
DR GO; GO:0000045; P:autophagosome assembly; IEA:InterPro.
DR GO; GO:0043170; P:macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0006807; P:nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR CDD; cd22887; Atg16_CCD; 1.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 3.
DR InterPro; IPR045160; ATG16.
DR InterPro; IPR013923; Autophagy-rel_prot_16_dom.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19878; AUTOPHAGY PROTEIN 16-LIKE; 1.
DR PANTHER; PTHR19878:SF6; AUTOPHAGY-RELATED PROTEIN 16-1; 1.
DR Pfam; PF08614; ATG16; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 22..210
FT /note="Autophagy-related protein 16"
FT /evidence="ECO:0000259|Pfam:PF08614"
FT REPEAT 323..356
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 367..408
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 409..450
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 545..576
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 578..612
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 68..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..237
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..278
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 612 AA; 68625 MW; FF47F49BA3A277F8 CRC64;
METDAEQVMA ERRGECLWKK HVAEQLKLRD REQRQAFEEI ILQYNRLLEK ADLQAVLSER
YQADKYDVQR GHESSAADSS RSDALQQEMA QMRIRHQEEL TELHKKRGEL AQSVIELNNQ
IQQKDREIQN NEAKMLEYQQ QISSLEGDCR ELRSCLQDLE RANQTLKDEY DALQITFSAL
EEKLRKTTED NQELVSRWMA EKAQEANRLN AENEKDSRRR QAKLQKELAD AAKEPLPIEA
DDDIEVLTED AGKAGGETSP SRLLTRTPSK KISQQPPGGL LDSISLMFGR RSANSFSTSP
ESSEAPSGVC TEVRVPTTAL HVFEAHDGEV NAVRFSPGSR LLATGGMDRR VKLWEVVAGR
CEPKGALTGS NAGITSIEFD SAGSYLLAAS NDFASRIWTV DDYRLRHTLT GHSGKVLSAR
FLLDNARIVS GSYDRTLKLW DLRSKVCMKT VFAGSSCNDI VCTEQCVMSG HFDKKVRFWD
IRAESIVREL ELFGRVTSLD LNHDRTELLT CSRDDLVKIV DLRTNAVKQT LSAQGFKCGA
DWTRVTFSPD GSYVAGGSAD GALYIWNVLT GKVDRTLDRN HSSAINSVSW SPSGAYVASV
EKGSRAILWS DM
//