ID I3KLU4_ORENI Unreviewed; 563 AA.
AC I3KLU4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Tripartite motif-containing protein 16 {ECO:0000313|Ensembl:ENSONIP00000022089.2};
GN Name=LOC100708482 {ECO:0000313|Ensembl:ENSONIP00000022089.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000022089.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000022089.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; I3KLU4; -.
DR STRING; 8128.ENSONIP00000061329; -.
DR Ensembl; ENSONIT00000022108.2; ENSONIP00000022089.2; ENSONIG00000017518.2.
DR eggNOG; ENOG502QW2Y; Eukaryota.
DR GeneTree; ENSGT00940000162978; -.
DR HOGENOM; CLU_013137_0_2_1; -.
DR TreeFam; TF351086; -.
DR Proteomes; UP000005207; Linkage group LG10.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0002376; P:immune system process; IEA:UniProtKB-KW.
DR CDD; cd19769; Bbox2_TRIM16-like; 1.
DR CDD; cd16601; RING-HC_TRIM39_C-IV; 1.
DR CDD; cd16040; SPRY_PRY_SNTX; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 4.10.830.40; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR003879; Butyrophylin_SPRY.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR006574; PRY.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR000315; Znf_B-box.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR25465; B-BOX DOMAIN CONTAINING; 1.
DR PANTHER; PTHR25465:SF35; FINTRIM FAMILY, MEMBER 83; 1.
DR Pfam; PF13765; PRY; 1.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00643; zf-B_box; 1.
DR Pfam; PF15227; zf-C3HC4_4; 1.
DR PRINTS; PR01407; BUTYPHLNCDUF.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00589; PRY; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 8..51
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 144..184
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT DOMAIN 373..563
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 56..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 181..291
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 563 AA; 64336 MW; 0442449F5E4B9945 CRC64;
MSFDQDTCYL CKEYLRDPVS IPCGHVFCSI CLKTYWDHAE HTGSFNCPEC RVSYSKRPTP
RRIGGSRHST LQRNTESFPP PPPSPDYNVA GPQDVGCDIC VGKKQKAVKS CLMCLAHYCE
KHLKPHYESA TFKRHKLVDE IGHLDRQICP QHQKGLELFC RTDQMCICVL CTVKEHKGHD
MVSAEQERSE EQQRLGATQA EIQERIHDRL KQMEELKHAV DSLKSSAQRA LQDCEKMFGD
MMRSIERMQQ EMAKLISSNK RAALNNAESH LERLTHEIAD LKARDNEITQ LSRTEDHIHF
IQSYHMLIAQ TEAEELPSVS VNPYFSFGPV TKAVSELKQQ LNDSSNDELV KVAKTVNKMT
FCELEDSKKK QYQSIKSESV FQEHHFTTYA CQLTLDQNTA YRQLYLSRGN RKAALKRDPQ
SYPDSPARFD SLPQVLCKEP LSGGTYYWEV DWSGEGASIG IAYKGIKRTG YGDSCRIGYN
RKSWSLFCSD SSYSARHNKD QQEVNAPYSS RIGVFLDHAG GTLSFYTVGE TMSLIHRFKA
SFSEPVYPGF WVWYESAITI IQL
//
