ID   I3KN92_ORENI            Unreviewed;      1087 AA.
AC   I3KN92;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 72.
DE   RecName: Full=Guanylate cyclase {ECO:0000256|RuleBase:RU003431};
DE            EC=4.6.1.2 {ECO:0000256|RuleBase:RU003431};
GN   Name=LOC100708131 {ECO:0000313|Ensembl:ENSONIP00000022587.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000022587.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000022587.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC         Evidence={ECO:0000256|RuleBase:RU003431};
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC       family. {ECO:0000256|RuleBase:RU000405}.
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DR   AlphaFoldDB; I3KN92; -.
DR   STRING; 8128.ENSONIP00000052695; -.
DR   Ensembl; ENSONIT00000022607.2; ENSONIP00000022587.2; ENSONIG00000017921.2.
DR   eggNOG; KOG1023; Eukaryota.
DR   GeneTree; ENSGT00940000164853; -.
DR   OMA; LPFDTIH; -.
DR   TreeFam; TF106338; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd06371; PBP1_sensory_GC_DEF-like; 1.
DR   CDD; cd14043; PK_GC-2D; 1.
DR   Gene3D; 3.40.50.2300; -; 2.
DR   Gene3D; 6.10.250.780; -; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR018297; A/G_cyclase_CS.
DR   InterPro; IPR001828; ANF_lig-bd_rcpt.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR028082; Peripla_BP_I.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR   PANTHER; PTHR11920:SF228; RETINAL GUANYLYL CYCLASE 1; 1.
DR   Pfam; PF01094; ANF_receptor; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW   ECO:0000256|RuleBase:RU003431};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT   DOMAIN          484..799
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   DOMAIN          871..1001
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   1087 AA;  120634 MW;  C3A2DA6273001C42 CRC64;
     AKAANRGDTS STTLSMTLHR GQLQRGTKSR SSIGNWMQLR WLLGACLWLL CIEEIWTTTF
     KIALVGPWSC DPLFSRAMPA AAVTLALSRL RTDTSMSRGY WYDIKVLDED CSASKALTNF
     GDFEGYGYAY IGPFNPALCH SASLMTEHWE AGLASPGCLD ADWPNLPPLT PPTRVLFTVL
     RFFGWAHVSI ITAATDLWES TGQEVASALR AMGLPIAPVV TMETGSKGGA REALKEIREA
     DKVKVVIMCM SSVLIGGEDQ RELLLTALEM GMVSNGYVFI PYDALLYAMP YQHTVFNQLT
     NSTQLRHAYS AVLTVTMASD QSFYEAFREA QMSREIHSGV STTEVSPLFG TIFNMVYFVA
     KAVEERRQAG GGHWVTGNQL MKSDGGFDFQ GFNQVLYGGT EGRGLQASYV VLDSDGDRLV
     PTHSLSPTHT DGMTGGLRPL SRSFVFPGGK PPSASFCWFN PDEACSGGVF TDPQRGWELS
     SFFSHVSKSL DRNTNGAVTA NKMILTLDDI VFIDTQVSRK KLNDESIMKS LLEIKTPLRS
     IARSYILTTP ESSNIGILEG DWVWLKKFST GKTPTEASQH TQNMFSQLRE MRHENLNLCL
     GLFVDSGIFA LVVEHCPRGS LADLLADGNV RLDWMFKSSL LMDLIKGMKY LHLRGLTHGR
     LKSTNCLVDG RFVLKITDYG LPMILKSQGI SIPEDPHDML WTAPELLRNP VSGGSFAGDV
     FSFSIIIQEV ISRTLPYAMM DMPAHEIVER LKQPPPLCRP IVSVDEAPTE CLTLMNECWN
     EDPSKRPSFD DIFKQFRGIS RGRRANIIDS MLRMLEQYSS NLEDLIRERT DELEIERTKT
     DKLVGQLLPK SVAQALKKGK PVQPEHYSDC TLYFSDIVGF TTISALSEPI EVVDLLNDLY
     TMFDAIIALH DVYKVETIGD AYMVASGVPN RNGNRHAAEV ANMSLDILHS IGAFKIKHMP
     EIKVKIRIGL HSGAVVAGVV GLKMPRYCLF GDTVTTASLM ESSGLPYRIH ISLSTVKVLT
     SLKVGYHIDT RKVKGTEDTY WLMGREGFNK PLPVPPDLTG GNHGISLDEI PVDRRQKFLD
     RQNKMKK
//