ID I3KPC6_ORENI Unreviewed; 1078 AA.
AC I3KPC6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Retinoblastoma-like protein 2 {ECO:0000313|Ensembl:ENSONIP00000022971.2};
GN Name=RBL2 {ECO:0000313|Ensembl:ENSONIP00000022971.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000022971.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000022971.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the retinoblastoma protein (RB) family.
CC {ECO:0000256|ARBA:ARBA00009475}.
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DR RefSeq; XP_005470283.1; XM_005470226.3.
DR AlphaFoldDB; I3KPC6; -.
DR STRING; 8128.ENSONIP00000022971; -.
DR Ensembl; ENSONIT00000022991.2; ENSONIP00000022971.2; ENSONIG00000018239.2.
DR GeneID; 100692495; -.
DR KEGG; onl:100692495; -.
DR CTD; 5934; -.
DR eggNOG; KOG1010; Eukaryota.
DR GeneTree; ENSGT00950000183202; -.
DR HOGENOM; CLU_008943_0_0_1; -.
DR InParanoid; I3KPC6; -.
DR OMA; MHWLACA; -.
DR OrthoDB; 519973at2759; -.
DR TreeFam; TF105568; -.
DR Proteomes; UP000005207; Linkage group LG7.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR Gene3D; 1.10.472.140; -; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 3.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR002720; RB_A.
DR InterPro; IPR002719; RB_B.
DR InterPro; IPR015030; RB_C.
DR InterPro; IPR028309; RB_fam.
DR InterPro; IPR024599; RB_N.
DR PANTHER; PTHR13742; RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATED; 1.
DR PANTHER; PTHR13742:SF8; RETINOBLASTOMA-LIKE PROTEIN 2; 1.
DR Pfam; PF11934; DUF3452; 1.
DR Pfam; PF01858; RB_A; 1.
DR Pfam; PF01857; RB_B; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SMART; SM01367; DUF3452; 1.
DR SMART; SM01368; RB_A; 1.
DR SMART; SM01369; Rb_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 3.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Cyclin {ECO:0000256|ARBA:ARBA00023127};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 63..205
FT /note="Retinoblastoma-associated protein N-terminal"
FT /evidence="ECO:0000259|SMART:SM01367"
FT DOMAIN 377..571
FT /note="Retinoblastoma-associated protein A-box"
FT /evidence="ECO:0000259|SMART:SM01368"
FT DOMAIN 778..948
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 961..1078
FT /note="Retinoblastoma-associated protein C-terminal"
FT /evidence="ECO:0000259|SMART:SM01369"
FT REGION 589..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 862..937
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1040..1062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 589..633
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 892..927
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1041..1055
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1078 AA; 119121 MW; 22D5B6DBC77499DC CRC64;
MSDEDETAQR ARRGFEELCR ALNMDEEASG EAWRSYENIS RNFTLEGSEL HWLACALYVA
CRSSVPTVGK GTAEGNYVSL TRILRCSEMS LIEFFSKMKK WQDMADLPPD FRQSTDKLER
NFIVSAVIFK KYVPIFKSIF RAPSEEPPRV HRSRKQRRHP CTVTEVFNFC WVLFVHAKGN
FPMISDDLVN SYHLLLCALD LVFTNALLCN ARKDLLNPEF KGLPEDFGTK DFRPASGPFC
FMEQLCRLHD GLVLEAKGVK EHFWKPFIKK LFHKRILRGK EDSLTGFLDP MNFGDSLLAL
SRLYEEHVLA TGSLDERIFT GEGASEDIGT PGPCLCEGAE NQDSATFRLH TSLAASALKV
STPLTGRKYV QEGSLASPLS SAMKSVGRLH TLLSGTKQGP SAKLAETLRS CARDPSDAIS
QRLNDMFDVF SQHYEDDAAD GSRAIGKDIA VKYFHLAQAL YYRILESVIE REKMILGDAD
LSCILEQDIF HRSLLACCLE IVIFSYRPPG DFPNVLGIFQ LPAYHFYKVI EVLVRAEQGL
FREVVKHLNQ VEEQVLESLA WTGDSPLWES LRGAKDHAPS CQEVMPPQYL EQQDESSSGS
VPVTPVSHGA ELSSSSTLKG VSPSPTTLLD RYSSPPAGTA RRRLFVDPVD GEPGLTSSGS
ASTAVAKPTQ ASLVTAIPAG QTVVTMATAT VTANNGQTVT IPVQGIANES GGITFIPVQV
SVTGQAGAAL QSLPAQALAS TIAVQPATVK PAPKLVSSAL RKGSLSLFFR KVYHLASVRL
RDLCTRLDIM PELRRKIWTC FEYSLVHCTD MMMDRHLDQL LMCAVYVMAK VTKEDRSFQN
IMKCYRSQPQ ASSNVYRSVL ISGRRRRHSS TNKPNPPTDG GQDAACGDVS PVPIRSSSTL
PTPQPGSAPS TPTNTSNKTS CTSTANAGEE EQEEERGDLI HFYNNVYIKQ MTPFALKYSP
NSPSAGVDTP PLCPYPSLRT GSPRRMLLSS KHSIYISPHK AGSAPSLMTP REKIYYYICS
SPPNRLQEIN SMIRTGETPT RKRGMALEEE ASPKRVCPDS NALMRRLQDV ANDRSSSH
//