ID   I3KPT0_ORENI            Unreviewed;       561 AA.
AC   I3KPT0;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 64.
DE   SubName: Full=Adenylate kinase 5 {ECO:0000313|Ensembl:ENSONIP00000023125.2};
GN   Name=ak5 {ECO:0000313|Ensembl:ENSONIP00000023125.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000023125.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000023125.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the adenylate kinase family.
CC       {ECO:0000256|ARBA:ARBA00007220, ECO:0000256|RuleBase:RU003330}.
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DR   AlphaFoldDB; I3KPT0; -.
DR   Ensembl; ENSONIT00000023145.2; ENSONIP00000023125.2; ENSONIG00000018367.2.
DR   GeneTree; ENSGT00940000155917; -.
DR   HOGENOM; CLU_034712_1_0_1; -.
DR   Proteomes; UP000005207; Linkage group LG18.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004550; F:nucleoside diphosphate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd01428; ADK; 2.
DR   CDD; cd22978; DD_AK5; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   HAMAP; MF_00235; Adenylate_kinase_Adk; 1.
DR   InterPro; IPR000850; Adenylat/UMP-CMP_kin.
DR   InterPro; IPR033690; Adenylat_kinase_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR23359:SF79; ADENYLATE KINASE ISOENZYME 5; 1.
DR   PANTHER; PTHR23359; NUCLEOTIDE KINASE; 1.
DR   Pfam; PF00406; ADK; 2.
DR   PRINTS; PR00094; ADENYLTKNASE.
DR   SUPFAM; SSF47391; Dimerization-anchoring domain of cAMP-dependent PK regulatory subunit; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS00113; ADENYLATE_KINASE; 1.
PE   3: Inferred from homology;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU003330};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003330}.
SQ   SEQUENCE   561 AA;  63279 MW;  3C57BA2C698E7FD0 CRC64;
     MNTNDAKEYL ARREIPQLFE SLLTGLMYYR PDDPIEYLEG CLKKARELGG PEKVRWDTFV
     GQEKKSLPPL NGGQSRRSLF RNVLPDSPNF PYRRYDRLPP ISQFSIESDS DLSETAELIE
     EYEVFDPSRP RPKVILVIGG PGSGKGTQSL KIAERYGFQY MSVGELLRKK MIHNATSNRK
     WSLIAKIITN GELAPQETTI TEIKQKIMKI PDANGIVIDG FPRDVGQALS FEDQICTPDL
     VVFLACTNHR LKERLQKRAE QQGRPDDNPK AIERRLTNFK QNTIPLVKYF QERGLIVTLD
     ADRDEEEVFC DIGMTLDNKL FPSKEPAAGP SELDLSLLGE TSSLADVACK DDEVSLSDHL
     TARIWPYFRL FLSLSLSLCV SGGPGSGKAL QCERMEERFG LRRVTLGDLL CSELQSNSDR
     GRYLRDALER GEQLPEDTLL ELLCDAVVSS VRQGKGLVIS GFPRDLRQAE EYEAKMGEPS
     AVLLLNCSAD TMSNRLQCRG RSGFQAAPDR ESVLHRRVES FCSDTQAVAA HYEHKRLLHT
     AFTSYNIIYS VFCVLIHSRL L
//