ID I3KQB3_ORENI Unreviewed; 2221 AA.
AC I3KQB3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=ATP-binding cassette, sub-family A (ABC1), member 4b {ECO:0000313|Ensembl:ENSONIP00000023308.2};
GN Name=ABCA4 {ECO:0000313|Ensembl:ENSONIP00000023308.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000023308.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000023308.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR STRING; 8128.ENSONIP00000033668; -.
DR Ensembl; ENSONIT00000023328.2; ENSONIP00000023308.2; ENSONIG00000018513.2.
DR eggNOG; KOG0059; Eukaryota.
DR GeneTree; ENSGT00940000155624; -.
DR HOGENOM; CLU_000604_19_0_1; -.
DR TreeFam; TF105191; -.
DR Proteomes; UP000005207; Linkage group LG18.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR PANTHER; PTHR19229:SF190; RETINAL-SPECIFIC PHOSPHOLIPID-TRANSPORTING ATPASE ABCA4; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 654..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 694..718
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 730..753
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 759..781
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 833..856
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1334..1355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1635..1657
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1664..1681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1716..1734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1746..1768
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 927..1158
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1886..2118
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 2221 AA; 251271 MW; 5C8D47847811C19A CRC64;
MKTGSQVSLL LWKNWTLRKR QKIRFLVEIF WPVLLFIGLV WLRKANPLYQ QHECHFPNKA
LPSTGILPWI QGIFCNVNNP CFRYPTRGES PGVVSNYNNS VLARFYTNIQ KLLLNDTEVQ
QLGRLWHEMS SFSNFMETLR NNPSAVSGRG LKVDDILKDD EVLTAFLLRD AGLSESIVHQ
LVNAQIRLEQ FAFGVPDLQL KDIACSQALL ERFLIFPTRM GLHGVRNAMC ALSQQRLQRI
EDVLYANLDF FKIFKLMPQV LDRSSVGIDL HFWGQALQAT SAKIQDVSSP NSSQELLKAV
SSLFQTGGPS SFTQLMSSVS SLFCGYPEGG GSRVLSFNWY EDNNYKVFLG VNGTKNHNYV
YDDTTTPFCN ALMQTLESNP VTKIVWNSVK PLLMGKILYT PDSPAARKIL KSANTTFEEL
ERLQNMAKAW EEVGPQLWAF FQNSVQMNMI RDTLRNPTVM QFMDNSLVGT EFTTKDILNF
LYNGPERERE AGIPNFDWRN IFNITDQLIR MFNQYGECIS LDKFVAYTDE SQMIHEALHL
LEENKFWAGV VFMDLYPWTT SVPPHVKYKI RMDIDAVERT NKIKDRYWDP GPRADPMEDQ
RYIWGGFAYL QDMIEHGIIK IHTGNDWPLG VYVQQMPYPC YVDDLFMITL NRCFPIFMVL
AWIYSVSMTV KSIVLEKELR LKETLKAMGV SNGVIWYTWF IDSFLMMTAS TVLLTSIVMG
GKVLNYSDPI LVFFFLMTFT VATIMQCFLM SVFFNKANLA AACSGIIYFT LYLPHILCFA
WQDRITKSMK LAASLLSPVA FGFGTEYLSR YEEQGLGLHW NNIKTSPLEK DTYSFLTSIL
MMIFDAVLYG VLAWYLDNVF PGQYGIGRPF YFPFQPSYWQ RPKPSHTETA DGATVLILSC
FDDIFDLFSH ADQLFFEPDP VGLVMGVQVQ DLVKVFDGSS RPAVNCLNIN FYEGQITSFL
GHNGAGKTTT MSILTGLYPP TSGTAYINGR DIRTDIDIIR TSMGMCPQHN ILFNHLTVEE
HILFYSLLKG RTQAEAEREV EDMLVDLGLP HKRDDEAQNL SGGMQRKLSV AMAFVGGSKV
VILDEPTSGV DPYSRRSIWD LLLKYRTGRT VILSTHHMDE ADLLSDRIAI ISKGQLHCCG
SPLFLKNCFG VGFYLTLVRR IKDLRKKEVR MNFCSSCSAS CRDFLLPWFI TSLIHHHVPE
AKLIEMIGQE LTYLLPSKGF KHRAYASLFR ELEETLADMG LSSFGISDTS LEEVQMSNIY
LYLILESLTF SKPCLKILIS QIKKHNGVNP TNQSSDSSAG KGSRQVKGGF LILKQFHALL
VKRFHHATRS QKDFLAQIVL PASFVLIALI FTMIVPPFGE YPSLTLSPWM YGQQFTFFSN
ERPYDPKMKH FIERLLKPPG LGTRCMEGEV PCSNRTPEWD YPDVSPAVSN ILQSPAWNQR
NPSPSCQCST SNKLTMMPIC PDGAGGLPPR QRLEPTGDTM LDLTDRNISD YLVKTYPSLI
RTRSWKSSIL RYGGLSVGGQ LPILDVDPKD IRNVFHQLGR MFNITGGYYS RLALRDIGTF
LRYMESEFNI KVWYNNKGWH AMVAFINVAN NAILRAFLPT NANPVEFGIT AINHPLNLTK
EQLSEVTVLT TSVDAVVAIC VIFAMSFIPA SFVLYLIQER VTKAKHLQFV SGVSPVVYWV
TNFFWDMMNY TLSSAMVVGI FMAFDKKCYT SPSNLPALIA LLLLYGWSVT PMMYPLSYIF
NIPSTAYVSL SCINLFIGIN SSAITFILEL FENNRSLLVF NEGLKKVLLV FPHFCLGRGL
IDMAMNQAVT DVYARFGEDY TLDPFRWDFV GKNIAFMAVE GFVYFILNLL IQYRFFLDHC
PAQDEDDDVA AERQRIYDGG SKADILQIRD LSKTYVGRKR AAVDRICVGV PAGECFGLLG
VNGAGKTTTF KMLTGDTDVT SGEASVAGYS ILTEILDVHQ NMGYCPQFDA IDELLTGREH
LYLYARLRGV PESEIPRVAE WGIQKLGLSE YAGRCAGTYS GGNKRKLSTA IAMIGCPALV
LLDEPTTGMD PHSRRFLWNA IMSVIQDGRA VVLTSHSMEE CEALCTRLAI MVNGTFKCLG
TIQHLKYKFG DGYVVTMKIK PAKAGLSPEL EPVESFMETS FPGCVQREKH YNTLQYEIAS
SSLARIFQLV VANKDRLSIE DYSVFVNFAK QQAGEDEELT LHRRTAGGRK DIKISPVKRK
T
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