ID   I3KQR5_ORENI            Unreviewed;       986 AA.
AC   I3KQR5;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 64.
DE   SubName: Full=Transcription factor E2F5 {ECO:0000313|Ensembl:ENSONIP00000023460.2};
GN   Name=LOC100699665 {ECO:0000313|Ensembl:ENSONIP00000023460.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000023460.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000023460.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; I3KQR5; -.
DR   Ensembl; ENSONIT00000023481.2; ENSONIP00000023460.2; ENSONIG00000018639.2.
DR   GeneTree; ENSGT00940000157414; -.
DR   HOGENOM; CLU_011297_1_0_1; -.
DR   Proteomes; UP000005207; Linkage group LG18.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR025875; Leu-rich_rpt_4.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR15454:SF34; LEUCINE-RICH REPEAT AND COILED-COIL DOMAIN-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR15454; NISCHARIN RELATED; 1.
DR   Pfam; PF12799; LRR_4; 1.
DR   SMART; SM00365; LRR_SD22; 3.
DR   SMART; SM00369; LRR_TYP; 3.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   PROSITE; PS51450; LRR; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   REGION          233..264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          279..378
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          388..471
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          497..545
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          569..685
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          742..892
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          930..982
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        297..328
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        329..351
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   986 AA;  113213 MW;  301C71BBA9D2E108 CRC64;
     IAGGQVLLDI PLIPTVTSLN LHCNHIPRIE GLTSAWHLRH LDLSSNCISK IEGLSSLTSL
     RTLNLSCNLI TKVEALNGLV NLTRLNLSYN QINDLSGLLY LHGTEYKLKH LSLHSNHLDS
     IDHLLQCLLG IQGLREVTLS QDGRDNPVCR SPGYREIVLQ SLPQVSVLDG LNRLGNPSPQ
     SLSSLCDIPG LEDYVDLLLS SDTSHNEAVR GDAPLTTPRI DQLLTQFRQR SATSEVITDP
     VTQPEPPCTQ PVRSTVTDKG DPVSEERIRK LEHQMSQLIQ QNPADNKSRR SAHSVVMVRK
     AKRDTDRTSE SECDSGKENR RRTRIPKYHD SVTSSTTTKE TKRSESTGSA EAVRPTRKGP
     LRAAKASGDM KTRSTEEEET YRTIVEERDQ ERERRWKAEQ AVRKLTEELK CLQTKVSEEK
     DLQSMALHTT DRLKELLLKE RSGHSELQAR VEEMEGRCRS LTQQLEQARS CEEQHKTSLH
     RLEESISHGE ALRAHQQAEE IKRQQELQNK AAALKRELDI QRASVRQHKD KLQQLHELLA
     AREQEHRKQL ELRLQPGGAD FRDAVAKEVA SVEERHSHKE AELQEKLAEG RKQYTALEDE
     FRMALTIEAA RFSEVKEACD QMTAELMELK ATLAQSQERE RKSGSLVQEL TAMVKEQKSR
     ISELIKAKRD AVTDLKSRLH SLEAEVGQDR RLGLQLELLK KDKARLLSQL TAQESVIDGL
     RAERKIWGQE LAQQGASLAQ DRGRLEARLE VLSAELEAQR KQNEKDNDTL RIKAKIMDDQ
     TETIRRLKES LQERDDQIRR LKEEAAKAQK RLQEQLEEET TQQAELKERV EHLSLRKEEL
     KQQLEDKEAE LEQVKRVYSE STKKWQEKAD LLTRLESQVK RMKENFDSRE RLLLEEREKA
     TEAHRAALEK LHYVDDAFRR QLESVQAAHQ AELLRLANEK QQKIEEANQK VFEVEEEMRQ
     LLEETETNKR IMEEKMKRLS SVLKDF
//