ID I3KR26_ORENI Unreviewed; 1437 AA.
AC I3KR26;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Rho guanine nucleotide exchange factor 11 {ECO:0000313|Ensembl:ENSONIP00000023571.1};
GN Name=arhgef11 {ECO:0000313|Ensembl:ENSONIP00000023571.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000023571.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000023571.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004370}.
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DR RefSeq; XP_019209676.1; XM_019354131.1.
DR STRING; 8128.ENSONIP00000064664; -.
DR Ensembl; ENSONIT00000023592.2; ENSONIP00000023571.1; ENSONIG00000018723.2.
DR GeneID; 100698006; -.
DR CTD; 9826; -.
DR eggNOG; KOG3520; Eukaryota.
DR GeneTree; ENSGT00940000158350; -.
DR HOGENOM; CLU_003962_5_0_1; -.
DR OrthoDB; 2875542at2759; -.
DR TreeFam; TF106495; -.
DR Proteomes; UP000005207; Linkage group LG3.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR015212; RGS-like_dom.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR45872:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 11; 1.
DR PANTHER; PTHR45872; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF09128; RGS-like; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 50..114
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 740..926
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 258..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 532..699
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1080..1134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1173..1198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1240..1276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1289..1328
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1391..1437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..548
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..610
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 646..664
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1080..1133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1247..1274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1391..1416
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1437 AA; 159478 MW; F79D5C15AEDC0B1A CRC64;
MSLRQPTSTL DRINSLTIGD SERKSSAPQQ REPTAEIIPD ITGTGLVHRC VIVQKDQLGF
GFTVCGERVK LVQNVRPGGA AVKAGVQEGD RIIKVNGSLV SSMSHQEVVK LIKSGPYVAL
TLQGPSPSTH SLPLEPLQTD LTLNQRASLA GEAAPPPPPP LPSGLSSTPS QRITGPKPLQ
DPQVQKHATQ ILRKMLEQEE AELQDLMDEQ LRNPSPSLEE RIESAKRRAH QVRVKIQQDV
EGTRSESVTG YFIAGEGRQS MDSSEGDMEA FESPHSSPSF SFRTPLHRRQ WSDISTLSDS
GGKAQIIGPE EEDEEYDGYA FNEMDGPYQD IDLLKTRPAH MAVFMRYVFT QLLDPNPLLF
YLSVEAYLGS LPKDARTLAP QICSLFLEPD APLKIKVREE YLADIENRLH AQEDIRGPLS
ELQQLVLPEI QDQLQDYRNK QMMGLGSLFG EGDLQHLDGD TVKEKQVVDK QVTALWEILS
KHEEDRSSTL ASAVILYLRH SGIKPRDSKV FPGLTTEKDK WITFLKPKKL SGTKKEKDGE
DKKRNPILKY IGKPRTTSQS TFHVPLSPTE VRPGSVRNII QQFENSTETG EELSDGADPQ
RLSSSSLGDE MDSPLPVRLA RSESLKAQGE GRRRGGTSGA ESVPRSRSDV DMDDCADERD
GPGLRPLQHS ASSSASSNSA RSLENPTPPY TPRSRRRSVE SPLALLPDVV ALEDDVMDSK
TWQETVTPQL LATLSPSEVD RQAVIYELFT TEVSHLRTLR VLDQVFYQKM RTVLTSDELA
CIFPNLPQVY ELHASLCEAM KKRRESPIVQ DIGDVMLTRF EGAAGDEFQE QASQLCCQQS
QALELIKSKQ RKDARFAHII QECEASPHCR RLQLKDLLVS EMQRLTKYPL LLDKIIKYTE
AGSSDLPLLQ RVHTCCRGIL QSVNEDVRES EHRQRLSEYQ RRLDAAPQFK NVDLTTKRMI
HEGPLTWKVN KEKLIEIQAL LLSDCLVLLQ KGPDDRLQLR YHSSRLGVSG GGSGDSKTSF
SPLMNLASLL VRPVATDKKA LYIISTTDMQ IYELVAATTS KKEIWKDLLE KAISAAGGSS
PLMNHSSIPM SSPSLRSSSP VSTGSNAYGD NSMTEQSDST ETHSNNDEPA LCHSTPADQS
EAFICGDRQG VAEAALQDVE TLRQLILQDF GEDGWSHDSD DTPTNETATE SISFTERQRP
ESLETVLSCC TDEWEAEPEE LLLAKAPKPS FQVVRKAVVA GPPPSSSSVA EDITDDVTLP
SNQSSKSRSE AKKQGNTFYL VMPIEQGESM TEDLNEPPTP TASHFPPPVE EVTSPQTQME
EEPAARGLEA NQSETMQLEQ EKETGHLQAA QHTHVIRNVD EIFHTIEELM TKLRHLKEIE
KAHYKLLETL RESSVSQESE DQQCRSATVS RTPSLERSSG DGKEGRPAEP KILSTGF
//
