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Database: UniProt
Entry: I3KRB1_ORENI
LinkDB: I3KRB1_ORENI
Original site: I3KRB1_ORENI 
ID   I3KRB1_ORENI            Unreviewed;       244 AA.
AC   I3KRB1;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   08-NOV-2023, entry version 54.
DE   RecName: Full=Thymidine kinase {ECO:0000256|RuleBase:RU000544};
DE            EC=2.7.1.21 {ECO:0000256|RuleBase:RU000544};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000023656.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000023656.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + thymidine = ADP + dTMP + H(+); Xref=Rhea:RHEA:19129,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17748, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:63528, ChEBI:CHEBI:456216; EC=2.7.1.21;
CC         Evidence={ECO:0000256|ARBA:ARBA00033702};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19130;
CC         Evidence={ECO:0000256|ARBA:ARBA00033702};
CC   -!- SIMILARITY: Belongs to the thymidine kinase family.
CC       {ECO:0000256|ARBA:ARBA00007587, ECO:0000256|RuleBase:RU004165}.
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DR   AlphaFoldDB; I3KRB1; -.
DR   STRING; 8128.ENSONIP00000023656; -.
DR   Ensembl; ENSONIT00000023677.2; ENSONIP00000023656.2; ENSONIG00000018789.2.
DR   eggNOG; KOG3125; Eukaryota.
DR   GeneTree; ENSGT00390000011309; -.
DR   HOGENOM; CLU_064400_3_1_1; -.
DR   InParanoid; I3KRB1; -.
DR   OMA; EAYEPRC; -.
DR   TreeFam; TF314839; -.
DR   Proteomes; UP000005207; Linkage group LG6.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.60.20; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001267; Thymidine_kinase.
DR   InterPro; IPR020633; Thymidine_kinase_CS.
DR   PANTHER; PTHR11441; THYMIDINE KINASE; 1.
DR   PANTHER; PTHR11441:SF0; THYMIDINE KINASE, CYTOSOLIC; 1.
DR   Pfam; PF00265; TK; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00603; TK_CELLULAR_TYPE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000544};
KW   DNA synthesis {ECO:0000256|ARBA:ARBA00022634,
KW   ECO:0000256|RuleBase:RU000544};
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU000544};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU000544};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000544}.
SQ   SEQUENCE   244 AA;  27219 MW;  A02951E4274D0701 CRC64;
     MSYRFYITAQ VCCFSKPDFP RVLPNSPRKA RGQIQVIFGP MFSGKSTELM RRVRRFQIAQ
     YNCLVIKYAK DTRYSDAGMA THDKSTMEAV PANSLRDVRP LALRACVIGI DEGQFFPDAV
     EFCEEMANLG KTIIVAALDG TFQRKPFGNI LNLVPLAESV VKLHAVCMQC FKEAAYTKRI
     GAEKEVEVIG GADKYQAVCR KCYGGLMVDK ENSSPFRNET PQNALIGKLV DSGVPRKLFS
     SLHL
//
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