ID I3KRZ5_ORENI Unreviewed; 853 AA.
AC I3KRZ5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Active breakpoint cluster region-related protein {ECO:0000313|Ensembl:ENSONIP00000023891.1};
GN Name=LOC102077238 {ECO:0000313|Ensembl:ENSONIP00000023891.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000023891.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000023891.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}. Cell projection, dendritic spine
CC {ECO:0000256|ARBA:ARBA00004552}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
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DR RefSeq; XP_005463906.1; XM_005463849.3.
DR AlphaFoldDB; I3KRZ5; -.
DR STRING; 8128.ENSONIP00000023891; -.
DR Ensembl; ENSONIT00000023912.2; ENSONIP00000023891.1; ENSONIG00000018976.2.
DR GeneID; 102077238; -.
DR KEGG; onl:102077238; -.
DR eggNOG; KOG4269; Eukaryota.
DR GeneTree; ENSGT00940000153491; -.
DR InParanoid; I3KRZ5; -.
DR OMA; QDQYRFC; -.
DR OrthoDB; 2916231at2759; -.
DR TreeFam; TF105082; -.
DR Proteomes; UP000005207; Linkage group LG3.
DR GO; GO:0030424; C:axon; IEA:UniProtKB-SubCell.
DR GO; GO:0043197; C:dendritic spine; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR037769; Abr/Bcr.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23182:SF6; ACTIVE BREAKPOINT CLUSTER REGION-RELATED PROTEIN-LIKE; 1.
DR PANTHER; PTHR23182; BREAKPOINT CLUSTER REGION PROTEIN BCR; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 87..294
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 491..606
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 639..825
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
SQ SEQUENCE 853 AA; 96476 MW; 54342DAE47DA3C12 CRC64;
MLRTATLSQR AEERACFSAM DVYQEAVQYL ESQNIPVSAA VAEEADVLEE DVFPEEAVSC
FLSPLNTESV DFPDTPTTCS KEEWLERRLT VLKGILESEE IYLRELDTLL MPMKALRASA
GTSQPVLSSQ QVQTVFYQVP ELRDVHQTFY TGLKARLSAY DQTEISTGNE TEIRCRGFEL
VVGDLFQKMV SQIGLYGGFI ENYVKAVEVV RKCTHSDPRF RTLAESMMSN NGTDKARTTY
TFEALLYKPL DRVTKTTLVL QDLLKTTPTE HRDYTALQEA LRLSRSFLSG VNESSQSKRE
VTLSRGMRRQ LMRDGFVVDV SEGERSLRHL FLYTDLLLCT RFKHANRGKQ DQYRFCWYLP
LAGLKLRWVA DKERPPETNA RLHNIRTKMY VLRQQLLQQL RQNPKTSRSL AARSQKKLEQ
MELMLLTHLI AYRLELHSPS GKSHALLFSS LYELEEWRQA IHKLTTTNIE TVPPDLLTLT
SSCVKLRMTQ QPPLHSTNAG LNEESLCGTL SVAIDSAVGL QEPACVYVCV EVDGFKFYDQ
QTQTHSSVLS LNPHWDQELS FQVDGAQNLR VLCVSQSNGQ DDTVLGKNTV KLDSKTLNKR
WKKQTLQLGQ VELTLSLKYC PHPLGPPSST VQQPPIFGVP IETVAKQEGV LVPHVVRCCV
EEVERRGMDE VGIYRISGTT SEISMLKAAF NTNLREAVTK LRSAEVNAVS GVLKLYFREL
PEPLIPTELF QSLTRSLDIQ DQNPRLVSML SLLQSCPDAN RHTFLYLLHH LQRVSERQHI
NKMSLLNLAT VFGPSLLRPP VAGQGHLGPT VDISQEVVVQ VQVVFSYLQC NNLPEAQLSL
PHDSDTEDEA THI
//
