ID I3KT12_ORENI Unreviewed; 954 AA.
AC I3KT12;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=FERM, ARH/RhoGEF and pleckstrin domain protein 2 {ECO:0000313|Ensembl:ENSONIP00000024258.2};
GN Name=FARP2 {ECO:0000313|Ensembl:ENSONIP00000024258.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000024258.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000024258.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; I3KT12; -.
DR STRING; 8128.ENSONIP00000024260; -.
DR Ensembl; ENSONIT00000024279.2; ENSONIP00000024258.2; ENSONIG00000019275.2.
DR eggNOG; KOG3531; Eukaryota.
DR GeneTree; ENSGT00940000158642; -.
DR TreeFam; TF351276; -.
DR Proteomes; UP000005207; Linkage group LG23.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13193; FERM_C_FARP1-like; 1.
DR CDD; cd01220; PH1_FARP1-like; 1.
DR CDD; cd13235; PH2_FARP1-like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR041788; FARP1/FARP2/FRMD7_FERM_C.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45858; FERM DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45858:SF4; FERM, ARHGEF AND PLECKSTRIN DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 50..330
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 443..634
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 663..760
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 837..934
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 779..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 545..575
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 780..810
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 954 AA; 110415 MW; 4C521D30CA46FDAD CRC64;
MGEIEGSYRV LQTPGTRLGA QFNAGISTLE PGQSLSGNMV NRSISQGRGI QIRVQGLDDS
QEFFDVEPKA LGQILLSEVF HRGNLIESDY FGLEFQNMQM NWVWLEPTKP ISKQVRRPAN
TLFRLSVKFF PPDPGQLQEE YTRYLFSLQM KRDLMEGRLI CTENTGALLA SHLVQSEIGD
YDDAADREYL RINKLLPYQE KVQERIMELH RRHLGQTPAE SDFQILEIAR KLEMYGVRFH
PAADREGTKI NLSVAHMGLQ VFQGHTKINT FNWSKIRKLS FKRKRFLTKL HPEVHGPHQD
TLEFLMGSRD ECKVFWKICV EYHSFFRLFD HPQPKSKAVL FTRGSSFRYS GRTQKQLVEY
VRENGAKRTP YQRYVYSVVD SPQLSPVASK GPLCLSPSFQ MSNLSLPGQT PSPLQSPILS
EVGSNARLEE EEEGRRKRYP TDKAYFIAKE ILTTERTYLK DLEVITVWFR SAVIKENAMP
EGLMTLLFSN IDPIYEFHRG FLKELDQRLA LWEGRSNAHV KGDYQRIGDV MLKNMCALKE
FTSYLQKHDE VLTELEKASK RLKKLETVYK EFELQKVCYL PLNTFLLKPI QRLMHYKLIL
ERLCKHYSPA HRDYDDCKEA LKEVAEIATQ LQSSLIRLEN FQKLTELQRD LIGIENLTAP
GREFIREGCL YKLTKKGLQQ RMFFLFSDML LYTSKGVTAT NQFKVHGQLP LHGMIVEESE
NEWSVPHCFT IYSAQRTIVV AASSKVEMGK WIEDLNLAID MAKKSQEKSS IFLDAGLSDR
SNRSSDEVSL EQESEDDMNS SRTSLDKQTH HRANTTMHVC WHRNTSVSMS DHSLAVENQL
SGYLLRKFKN SNGWQKLWVV FTNFCLFFYK THQDDFPLAS LPLLGYTVST PEESDGIHKE
YVFKLQFKSH VYFFRAESEY TFERWMEVIK SAASTTGRMS LLIPKGGPME MNRN
//
