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Database: UniProt
Entry: I3KUE6_ORENI
LinkDB: I3KUE6_ORENI
Original site: I3KUE6_ORENI 
ID   I3KUE6_ORENI            Unreviewed;      2568 AA.
AC   I3KUE6;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   25-OCT-2017, entry version 39.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1G {ECO:0000313|Ensembl:ENSONIP00000024742};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000024742, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000024742}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000024742}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [3] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSONIP00000024742}.
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DR   EMBL; AERX01002176; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01002177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01002178; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01002179; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01002180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01002181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01002182; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01002183; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01002184; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01002185; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 8128.ENSONIP00000024742; -.
DR   Ensembl; ENSONIT00000024763; ENSONIP00000024742; ENSONIG00000019655.
DR   eggNOG; KOG2302; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; I3KUE6; -.
DR   OMA; FWRLICD; -.
DR   OrthoDB; EOG091G02L1; -.
DR   TreeFam; TF313555; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0070509; P:calcium ion import; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR030154; VDCC_T_a1G.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF137; PTHR10037:SF137; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    147    167       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    234    254       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    363    385       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    391    416       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    803    821       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    833    854       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    924    943       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1000   1023       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1363   1381       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1401   1422       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1434   1453       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1498   1520       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1558   1579       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1599   1623       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1679   1696       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1716   1735       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1814   1838       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1850   1868       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1898   1919       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      104    427       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      802   1030       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1361   1633       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1679   1930       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1632   1659       {ECO:0000256|SAM:Coils}.
FT   COILED     1919   1953       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2568 AA;  284062 MW;  6B6E80C3414C2FA8 CRC64;
     MMAEDGGNLS GVPDAGASEG RSSLPRTFIR LNDLSGLGTG GGEHGEVSAV EPASPAPDGI
     SAAGEEMSAS GGDSLPYPTL APVVFFYLKQ TTRPRSWCLK MVCNPWFERA SMLVILLNCV
     TLGMFHPCED INCDSERCKI LQDFDDFIFA FFAIEMVIKM VALGIFGKKC YLGDTWNRLD
     FFIVLAGMLE YSLNLQNVSL SAVRTVRVLR PLRAINRVPS MRILVTLLLD TLPMLGNVLL
     LCFFVFFIFG IVGVQLWSGL LRNRCFVEDN FSFPLSVERG KYYHTENDDE NPFICSQPRE
     NGMRDCSSIP KLYEEGGLEC TLDIDSYNST DNTTCVNWNQ YYTNCSAGLI NPFKGAINFD
     NICYAWIAIF QVITLEGWVD IMYFVMDAHS FYNFIYFILL IIIGSFFMIN LCLVVIATQF
     SETKQRESQL MKEQRVRFMS NASTLASLSE PGSCYDELLK YLVHIIRKGA KQVAHICRLL
     ARRAGLHIAA SPPATDIQRS HSQRRRRKTS RQGSVSVHHI MHHHHQHHHH HYHLGNGSVR
     GGGSTRCLDS REIEGGAHNN NGGTLIANTG SGHLAVALPS SVTAATSDMN LAILSSPAAD
     SSSVCSVLNT NSGIAPGFFS LAPAPKSRAI KRNSVPFAAP GPKNYPTLQA RALAESRRGS
     IAASTLTNIN LNIPPMPQDR RPSSLVDPLS PTAQLSCQLS ARDLSTTSSA MDTAALTLDP
     ESCPYCAKAL ANESEGGTEG NETPGDSDSD GVYEFTQDLH HRDRRDSRQP KKKHRRLGKT
     AAKVVHFWRL VCDTFRKIVD SKYFGRGIMI AILINTLSMG IEYHEQPEEL TNALEISNIV
     FTSLFSLEML LKVLVYGPFG YIKNPYNIFD GIIVVISVWE IVGQQGGGLS VLRTFRLMRV
     LKLVRFMPAL QRQLVVLMKT MDNVATFCML LMLFIFIFSI LGMHLFGCKF GSERDGDTLP
     DRKNFDSLLW AIVTVFQILT QEDWNKVLYN GMASTSPVAA LYFIALMTFG NYVLFNLLVA
     ILVEGFQAEE VAKREDLHAQ LSLIQLPVVS GGDASKSCSE IDSFARSMED VNGSKKDLSA
     SAVVPVNGHV DLKSNLTPPL ITHTAATPMP VPKLPVGGES NPGYESRRGS SSSVDPACYD
     KSPTSVRSSS PYAPWSSGSG RTSRRSSWNS LGRAPSYKRQ KRQSGERRSL LSGEGGSSSE
     DGEGGGEGGG GLMEEDDASL ARTDSMSQSQ RGPRHRRMES VETRSSMDLP PDALLQVPYR
     YRSASMHSSR PPSLSHLRPP EHSDCNGKGS PSVLGPTHVS LEENTEDENA EEEVNLGRFA
     RLLRWLEKKQ PAWCKQRDTW SLYLFPSESR FRILCNKIIT HKMFDHVVLV IIFLNCITIA
     MERPRIDSKS AERVFLTVSN YIFTSIFVAE MTVKIVSMGF FFGDKAYLRS SWNVLDGMLV
     MISVIDILVS LISQSETKIL GMLRVLRLLR TLRPLRVISR APGLKLVVET LMSSLKPIGN
     IVVICCAFFI IFGILGVQLF KGKFFICQGE DVRNITNKSD CLQANYKWVR HKYNFDNLGQ
     ALMSLFVLAS KDGWVDIMYD GLDAVGVDQQ PIMNYNPWML LYFISFLLIV AFFVLNMFVG
     VVVENFHKCR RHQEAEEAKR REEKRLKRME KKRRKAQSKP YYSDYSPTRL LIHKMCTSHY
     LDLFITIVIG LNVITMSMEH YQQPKELDEA LKICNYIFTL IFVLESVFKL VAFGFRRFFK
     DKWNQLDLAI VLLSIMGITL EEIEVNASLP INPTIIRIMR VLRIARVLKL LKMAVGMRAL
     LDTVMQALPQ VGNLGLLFML LFFIFAALGV ELFGDLICDE LHPCEGLGRY ATFKNFGMAF
     LLLFRVSTGD NWNGIMKDTL RDCAQDTGTC YNTVVSPIYF VSFVLTAQFV LVNVVIAVLM
     KHLEESNKEA KEEAELEAEM MELEMEAGDM AARSPQLNPL TLGMDRSSSG GSPWRSPRGV
     DTEQERDGPM DSPTANITRD SVGIRAESPS CTEPQLEFVQ RRALFDSVSL VIQGSMEGEM
     SLMDNLSGSI CHYYALPPKP SKHSTDKKIP LAEMDALSLA SENSWSLALT DDSTPDDFNP
     LFLTTLECNA EQLGPGALRD DNLLSVRKPA VGRTHSLPND SYMFLSPQPV GQTSPTAAHP
     QGPQHILGTH RAQSGSSGSV RSQPAEFSQQ LTVPTDLFRP ISPHSHSDSE SIPRNPPSRR
     THTFSRTLRR QVAVSTDSQE ALCTDVGESS EGLVNVASLG LPPSPTPSIS STSPSSYHHH
     HHPTPQQPAL CLVPATPGAS PKPSRPSTVH TQHHDQHCLA SYSPCPSPPP PIPARPPQQE
     VSEDREVSLI NQVVLAGSDD ITAEDSSSGG GNKGYGSYAG CQESRSPCLR QLKRFHSADT
     QGRNALLPRP RPYSWLDDPR RHSVEVCSPV DSSPQCSTNS TSSGFVSRAD SLQIQSQIPA
     QTSPRRKKKM SPPCISVDPP EGLEPQSGLY PCLGGLSGMG LTGLGMPPPL PNRDTYLRRR
     APSSDSKDSF DLAVGEGSGQ DGGSPNPNTN SKLLTLPSFS FEKTSSEH
//
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