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Database: UniProt
Entry: I3KUE7_ORENI
LinkDB: I3KUE7_ORENI
Original site: I3KUE7_ORENI 
ID   I3KUE7_ORENI            Unreviewed;      2343 AA.
AC   I3KUE7;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   25-OCT-2017, entry version 32.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1G {ECO:0000313|Ensembl:ENSONIP00000024743};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000024743, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000024743}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000024743}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [3] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSONIP00000024743}.
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DR   EMBL; AERX01002176; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01002177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01002178; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01002179; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01002180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01002181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01002182; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01002183; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01002184; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AERX01002185; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSONIT00000024764; ENSONIP00000024743; ENSONIG00000019655.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0070509; P:calcium ion import; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR030154; VDCC_T_a1G.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF137; PTHR10037:SF137; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     17     37       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    104    124       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    233    255       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    261    286       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    656    674       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    686    707       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    777    796       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    853    876       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1216   1234       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1254   1275       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1287   1306       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1351   1373       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1411   1432       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1452   1476       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1551   1568       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1588   1607       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1686   1710       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1722   1740       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1770   1791       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        6    297       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      655    883       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1214   1486       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1551   1802       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1485   1512       {ECO:0000256|SAM:Coils}.
FT   COILED     1791   1825       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2343 AA;  260534 MW;  DD1E62469FF64E54 CRC64;
     FACHQATCAI AQDFDDFIFA FFAIEMVIKM VALGIFGKKC YLGDTWNRLD FFIVLAGMLE
     YSLNLQNVSL SAVRTVRVLR PLRAINRVPS MRILVTLLLD TLPMLGNVLL LCFFVFFIFG
     IVGVQLWSGL LRNRCFVEDN FSFPLSVERG KYYHTENDDE NPFICSQPRE NGMRDCSSIP
     KLYEEGGLEC TLDIDSYNST DNTTCVNWNQ YYTNCSAGLI NPFKGAINFD NICYAWIAIF
     QVITLEGWVD IMYFVMDAHS FYNFIYFILL IIIGSFFMIN LCLVVIATQF SETKQRESQL
     MKEQRVRFMS NASTLASLSE PGSCYDELLK YLVHIIRKGA KQVAHICRLL ARRAGLHIAA
     SPPATDIQRS HSQRRRRKTS RQGSVSVHHI MHHHHQHHHH HYHLGNGSVR GGGSTRCLDT
     NTGSGHLAVA LPSSVTAATS DMNLAILSSP AADSSSVCSV LNTNSGIAPG FFSLAPAPKS
     RAIKRNSVPF AAPGPKNYPT LQARALAESR RGSIAASTLT NINLNIPPMP QDRRPSSLVD
     PLSPTAQLSC QLSARDLSTT SSAMDTAALT LDPESCPYCA KALANESEGG TEGNETPGDS
     DSDGVYEFTQ DLHHRDRRDS RQPKKKHRRL GKTAAKVVHF WRLVCDTFRK IVDSKYFGRG
     IMIAILINTL SMGIEYHEQP EELTNALEIS NIVFTSLFSL EMLLKVLVYG PFGYIKNPYN
     IFDGIIVVIS VWEIVGQQGG GLSVLRTFRL MRVLKLVRFM PALQRQLVVL MKTMDNVATF
     CMLLMLFIFI FSILGMHLFG CKFGSERDGD TLPDRKNFDS LLWAIVTVFQ ILTQEDWNKV
     LYNGMASTSP VAALYFIALM TFGNYVLFNL LVAILVEGFQ AEEVAKREDL HAQLSLIQLP
     VVSGGDASKS CSEIDSFARS MEDVNGSKKD LSASAVVPVN GHVDLKSNLT PPLITHTAAT
     PMPVPKLPVG GESNPGYESR RGSSSSVDPA CYDKSPTSVR SSSPYAPWSS GSGRTSRRSS
     WNSLGRAPSY KRQKRQSGER RSLLSGEGGS SSEDGEGGGE GGGGLMEEDD ASLARTDSMS
     QSQRGPRHRR MESVETRSSM DLPPDALLQV PYRYRSASMH SSRPPSLSHL RPPEHSDCNG
     KGSPSVLGPT HVSLEENTED ENAEEEVNLG RFARLLRWLE KKQPAWCKQR DTWSLYLFPS
     ESRFRILCNK IITHKMFDHV VLVIIFLNCI TIAMERPRID SKSAERVFLT VSNYIFTSIF
     VAEMTVKIVS MGFFFGDKAY LRSSWNVLDG MLVMISVIDI LVSLISQSET KILGMLRVLR
     LLRTLRPLRV ISRAPGLKLV VETLMSSLKP IGNIVVICCA FFIIFGILGV QLFKGKFFIC
     QGEDVRNITN KSDCLQANYK WVRHKYNFDN LGQALMSLFV LASKDGWVDI MYDGLDAVGV
     DQQPIMNYNP WMLLYFISFL LIVAFFVLNM FVGVVVENFH KCRRHQEAEE AKRREEKRLK
     RMEKKRRSLT LTDLEVSGSG ADAESQEAQS KPYYSDYSPT RLLIHKMCTS HYLDLFITIV
     IGLNVITMSM EHYQQPKELD EALKICNYIF TLIFVLESVF KLVAFGFRRF FKDKWNQLDL
     AIVLLSIMGI TLEEIEVNAS LPINPTIIRI MRVLRIARVL KLLKMAVGMR ALLDTVMQAL
     PQVGNLGLLF MLLFFIFAAL GVELFGDLIC DELHPCEGLG RYATFKNFGM AFLLLFRVST
     GDNWNGIMKD TLRDCAQDTG TCYNTVVSPI YFVSFVLTAQ FVLVNVVIAV LMKHLEESNK
     EAKEEAELEA EMMELEMEAG DMAARSPQLN PLTLGMERDG PMDSPTANIT RDSVGIRAES
     PSCTEPQLER RALFDSVSLV IQGSMEGEMS LMDNLSGSIC HYYALPPKPS KHSTDKKIPL
     AEMDALSLAS ENSWSLALTD DSTPDDFNPL FLTTLECNAE QLGPGALRDD NLLSVRKPAV
     GRTHSLPNDS YMFLSPQPVG QTSPTAAHPQ GPQHILGTHR AQSGSSGSVR SQPAEFSQQL
     TVPTDLFRPI SPHSHSDSES IPRNPPSRRT HTFSRTLRRQ VAVSTDSQEA LCTDVGESSE
     GLVNVASLGL PPSPTPSISS TSPSSYHHHH HPTPQQPASY SPCPSPPPPI PARPPQQEVS
     EDREVSLINQ VVLAYAGCQE SRSPCLRQLK RFHSADTQGR NALLPRPRPY SWLDDPRRHS
     VEVCSPVDSS PQCSTNSTSS GFVSRADSLQ IQSQIPAQTS PRRKKKMSPP CISVDPPEGL
     EPQSGLYPCL DLRRRAPSSD SKDSFDLAVG EGSGQDGGSP NPNTNSKLLT LPSFSFEKTS
     SEH
//
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