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Database: UniProt
Entry: I3KUX4_ORENI
LinkDB: I3KUX4_ORENI
Original site: I3KUX4_ORENI 
ID   I3KUX4_ORENI            Unreviewed;      1343 AA.
AC   I3KUX4;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   25-OCT-2017, entry version 38.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSONIP00000024920};
GN   Name=LOC100705197 {ECO:0000313|Ensembl:ENSONIP00000024920};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000024920, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Ensembl:ENSONIP00000024920}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000024920, ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=25186727; DOI=10.1038/nature13726;
RA   Brawand D., Wagner C.E., Li Y.I., Malinsky M., Keller I., Fan S.,
RA   Simakov O., Ng A.Y., Lim Z.W., Bezault E., Turner-Maier J.,
RA   Johnson J., Alcazar R., Noh H.J., Russell P., Aken B., Alfoldi J.,
RA   Amemiya C., Azzouzi N., Baroiller J.F., Barloy-Hubler F., Berlin A.,
RA   Bloomquist R., Carleton K.L., Conte M.A., D'Cotta H., Eshel O.,
RA   Gaffney L., Galibert F., Gante H.F., Gnerre S., Greuter L., Guyon R.,
RA   Haddad N.S., Haerty W., Harris R.M., Hofmann H.A., Hourlier T.,
RA   Hulata G., Jaffe D.B., Lara M., Lee A.P., MacCallum I., Mwaiko S.,
RA   Nikaido M., Nishihara H., Ozouf-Costaz C., Penman D.J., Przybylski D.,
RA   Rakotomanga M., Renn S.C., Ribeiro F.J., Ron M., Salzburger W.,
RA   Sanchez-Pulido L., Santos M.E., Searle S., Sharpe T., Swofford R.,
RA   Tan F.J., Williams L., Young S., Yin S., Okada N., Kocher T.D.,
RA   Miska E.A., Lander E.S., Venkatesh B., Fernald R.D., Meyer A.,
RA   Ponting C.P., Streelman J.T., Lindblad-Toh K., Seehausen O.,
RA   Di Palma F.;
RT   "The genomic substrate for adaptive radiation in African cichlid
RT   fish.";
RL   Nature 513:375-381(2014).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSONIP00000024920}.
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DR   EMBL; AERX01002257; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_013129588.1; XM_013274134.2.
DR   STRING; 8128.ENSONIP00000024920; -.
DR   Ensembl; ENSONIT00000024941; ENSONIP00000024920; ENSONIG00000019794.
DR   GeneID; 100705197; -.
DR   eggNOG; KOG2302; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; FFFFIYA; -.
DR   OrthoDB; EOG091G00LC; -.
DR   TreeFam; TF313555; -.
DR   Proteomes; UP000005207; Unplaced.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005207};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     81    106       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    159    190       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    296    318       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    324    349       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    421    439       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    451    469       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    544    563       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    617    641       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    753    772       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    784    812       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    824    843       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    888    910       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    990   1012       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1062   1083       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1095   1118       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1125   1145       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1191   1211       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1272   1300       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       46    355       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      420    645       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      751   1022       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1061   1309       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1343 AA;  154060 MW;  3B7ACEB4230861CC CRC64;
     MHEIHDRHRG VVVEEQLPFP EVVPVCFGLK QTSRPRKWFL KIVSGPWLDY LSILVVLLSC
     VNDGMYQPCV EAKEESFTRE ILGSLVFLYF IMETLIKTIA LGFIGHKGSY LSSHWNKFDL
     FIIFAELMDY TFGFFNLHVE ASHAIKPMRL ISRVPSMRIL VTILLETAPM LGNVLILYAF
     VIHIFGVIGV QMWAGKLRNR CFLGEDILTK YNVSLSPYFV PIFGGQSSFI CSADDKGGGR
     FCSDVPPYQE DGKICTLAAD EPIQAGQCVN WNMYYNVCRA GDHNPDLGAI NFDNIVYAWI
     TIFQVVTLEG WTNIMYYVMD SYSFWSFVFF IFVTIMGSFI IMNVCAVIIA TQFSENFARV
     TTEQHAGPLS FKNLFRKFVS FLKMMTNRVH PTKSSTHVKP TLHQVWIPFK EKFNILINTK
     LFNRIIVIAI FITIVTMAIE HYNQPQELTR VLNVSNIIIT IIFVVEMIIK LIALSWMYFA
     DLDNIFDFVV VLISLWELGS QADGKLSVVR AFRVLRFVRL FHFLPYLKRQ LLVLKRTIGE
     ASTLCWLMLF VIFIFSIVGM HLFGCKFHFR SIDDETVDDR KNFDSLLWSM VTVFQILTQD
     DWNVVLYNAV AATSPWAAIY FIAIIVFGKN VLLNVLVGIV VDSFQARPSE NIHQDCPRCP
     SLTCEAESSL EESPRTITGE YSVPATEPSR SNGSTSASEI PSPQTKNNSF TRFLNRIQKV
     LLWCQQHKDW SLYMLSPQNR LRRFCQRLIS HKAFDHVILF FILLNCVTIA MERPSINPKS
     MERLILNASC CVFTAVFLIE MVIKVIALGL VIGKGSYCRS YWNLMDGFLV ILSLTNFIIT
     LVTSDKKNIL SILKVFRLLR TLRTLRMIKQ TPKLKLAVKA LVASAKPIGN IVLICCVLFF
     FFGILGVQLF KGKFFYCEGE NTSNITNKAE CLSANYTWVR KEYNFDNLPQ ALIALFVMYS
     KDGWMNIMYD GLDAVGVDQQ PVKNYNEWML IYFISFMVMS FFLLDMFIGV MVETFHVCQQ
     QQKQSLQRGG NSRDKRKGRE ENYFRHYSLV RRRIYDLTTS RFLELFMTVI IFINVVLMAL
     EHYNQPLYVE QMIEYSFYVF TVLLVLEIML KVVAFGVLRF IKNSWNVLDI AIVLVSFIFI
     VFTVMNMEDT LPINPSILKI TRVLRLAQVL KAKKIRVLLR TITKTLSQVG NLCLLFMFFF
     FIYAALGVEL FGNLECTLDY PCEGINQYAN FKNFGMALLT LYKVCTGDNW SGILKDTLRP
     CRPSDKACPS YLWWASPICF ATFVVMVHFV LANLVVAAVM QALEDSKEKR PKTESSDIMQ
     QPQESPGEPV ISSSAGTTEG VQL
//
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