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Database: UniProt
Entry: I3KWR0_ORENI
LinkDB: I3KWR0_ORENI
Original site: I3KWR0_ORENI 
ID   I3KWR0_ORENI            Unreviewed;      1343 AA.
AC   I3KWR0;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   24-JAN-2024, entry version 77.
DE   RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE            EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN   Name=mst1r {ECO:0000313|Ensembl:ENSONIP00000025556.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025556.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000025556.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR   STRING; 8128.ENSONIP00000025557; -.
DR   Ensembl; ENSONIT00000025577.2; ENSONIP00000025556.2; ENSONIG00000020282.2.
DR   eggNOG; KOG1095; Eukaryota.
DR   eggNOG; KOG3610; Eukaryota.
DR   GeneTree; ENSGT00940000157842; -.
DR   HOGENOM; CLU_005158_0_0_1; -.
DR   TreeFam; TF317402; -.
DR   Proteomes; UP000005207; Linkage group LG5.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:InterPro.
DR   GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR   GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR   CDD; cd00603; IPT_PCSR; 1.
DR   CDD; cd01179; IPT_plexin_repeat2; 1.
DR   CDD; cd11248; Sema_MET_like; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR   Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR   Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   InterPro; IPR016244; Tyr_kinase_HGF/MSP_rcpt.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR24416:SF113; MACROPHAGE-STIMULATING PROTEIN RECEPTOR; 1.
DR   PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR   Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR   Pfam; PF01403; Sema; 1.
DR   Pfam; PF01833; TIG; 1.
DR   PIRSF; PIRSF000617; TyrPK_HGF-R; 1.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00429; IPT; 3.
DR   SMART; SM00423; PSI; 1.
DR   SMART; SM00630; Sema; 1.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF81296; E set domains; 3.
DR   SUPFAM; SSF103575; Plexin repeat; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   SUPFAM; SSF101912; Sema domain; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR000617-2};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW   ECO:0000256|PIRSR:PIRSR000617-3};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000617-2};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           20..1343
FT                   /note="receptor protein-tyrosine kinase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5025530845"
FT   TRANSMEM        932..955
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          25..508
FT                   /note="Sema"
FT                   /evidence="ECO:0000259|PROSITE:PS51004"
FT   DOMAIN          999..1296
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000259|PROSITE:PS50011"
FT   REGION          1322..1343
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        1167
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000617-1"
FT   BINDING         1120..1123
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000617-2"
FT   BINDING         1171
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000617-2"
FT   MOD_RES         1197
FT                   /note="Phosphotyrosine; by autocatalysis"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000617-4"
FT   MOD_RES         1198
FT                   /note="Phosphotyrosine; by autocatalysis"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000617-4"
FT   MOD_RES         1304
FT                   /note="Phosphotyrosine; by autocatalysis"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000617-4"
FT   MOD_RES         1311
FT                   /note="Phosphotyrosine; by autocatalysis"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000617-4"
FT   DISULFID        96..99
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT   DISULFID        128..136
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT   DISULFID        165..168
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT   DISULFID        291..360
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT   DISULFID        378..399
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT   DISULFID        513..531
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT   DISULFID        519..553
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT   DISULFID        522..538
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT   DISULFID        534..544
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
SQ   SEQUENCE   1343 AA;  150148 MW;  96AEA97FB31E23F7 CRC64;
     MVHWTRQWWA CVWFQTVLAF ALANCASLAP NPVNFSVVYT MPFFQAGGPI QNIVNNSFYQ
     EVYVASKNVI EAVNRSLEKV WELRTGPVGG SECHICNLCE IDKNHNFPED TDNQVLLLDT
     LFMYLYSCGS SQYGVCYFHQ LNPNGEPPSL SKCLFRKGSN SAANCPDCVA SPLGTKVTMV
     EEGQTVYFFV AASVNDSVTQ RYGRKSLSVR RPLATEDGFF SDVRGLTVLP SLRKTYHIEY
     VYSFFTQEFV YFLSVQRESP DQESSPFQTR LGRLPRNEWE MKRYRELILE CRFEPKRRRR
     NVASEPYKDI VYNVVQAAHF GKAGRELAEE LGAEEEDDIL YGVFAVTDDN GVTEHDSALC
     AFPMDNVNKA IADGVDDCCE SGPEQLSRGL CHFQPCESCP HESMENNATC RDHPTMVSKP
     YYRVDLFNRK MTNVLLTSLL VTTIENKTVA HIGTSTGRLL QLVLTRSSPV IFANYSLVEN
     QRVSSIAAVH SSEYLLFVVG DKMIQVPQRG PGCQHFLTCA MCLTAPKFMG CGWCSGVCSW
     ESECHNRWRN ESCPPGISGF FPRTAPPDGQ TELTLTGWEF QSPLRPAITS RTHQIRLGQT
     SCTVIPAKSN ITHLVCKIRS GATELFKPVN ITVEVHEGKV EGRYSIEGKA EMPGFTFVVP
     NITEIQPNYG PRVGGTLITV SGPHLDAGKT RRVTLNDVAL PKGNVSSIIC LSKEISEVRD
     VPLSVFIDKS PVLTTKVFYY KENPKITDVR PDCSFDRGSK IVIEGENLDS VYRTIIHFKP
     NESHLKSVST ECLGKSLPTR MECMTPVFHR DETVEGSLSF DMDGASSLWS KEFSYHPYGE
     PIPFETEGHV LNLYPGFDEV SLHHQKLNLV SSCMTIIMTV AGVDCGAKVL DNEITCRIPK
     NMTIPSEGLP VKISINGQVH NVGTVVRVSN HYMVGIVLGI LAALVAGAVL AFVVMKHLRK
     KKKASMVESH LTHSANRCGT NNVEMSPVGD YRRGVVSLSP PTPLVGPVAF PSLTYAGGRI
     DPTLTPLLPT EKIPITSFRP ELLEEVKDVL IPAEMLVVQK HRIIGKGKEL CTSFWNRITD
     VEEVEQFLKE GIIMKGFHHS NVLSLLGVLL PQEGLPLVVL PYMKHGDLRH FIRCEKRNPT
     VKDLIGFGLQ VAKGMEYLAQ KKFVHRDLAA RNCMLDESYT VKVADFGMAR DVFDKEYYSV
     QDHRKAKLPV KWMAIESLFT AWSFGVLMWE MLTRGASPYP EVDPYDITHY LLKGRRLPQP
     QYCPDPLYSI MLQCWDPDPE LRPSFATLVS AVSTILSGLE GEHYISLNVT YVNLDQPHPY
     PALTESADEY DSTDVEDSGS MSS
//
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