ID I3KWR0_ORENI Unreviewed; 1343 AA.
AC I3KWR0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 24-JAN-2024, entry version 77.
DE RecName: Full=receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902};
GN Name=mst1r {ECO:0000313|Ensembl:ENSONIP00000025556.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025556.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000025556.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR STRING; 8128.ENSONIP00000025557; -.
DR Ensembl; ENSONIT00000025577.2; ENSONIP00000025556.2; ENSONIG00000020282.2.
DR eggNOG; KOG1095; Eukaryota.
DR eggNOG; KOG3610; Eukaryota.
DR GeneTree; ENSGT00940000157842; -.
DR HOGENOM; CLU_005158_0_0_1; -.
DR TreeFam; TF317402; -.
DR Proteomes; UP000005207; Linkage group LG5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:InterPro.
DR GO; GO:0007411; P:axon guidance; IEA:UniProt.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IEA:InterPro.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd11248; Sema_MET_like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR016244; Tyr_kinase_HGF/MSP_rcpt.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR24416:SF113; MACROPHAGE-STIMULATING PROTEIN RECEPTOR; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 1.
DR PIRSF; PIRSF000617; TyrPK_HGF-R; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR000617-2};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR000617-3};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR000617-2};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1343
FT /note="receptor protein-tyrosine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025530845"
FT TRANSMEM 932..955
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..508
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT DOMAIN 999..1296
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1322..1343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1167
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-1"
FT BINDING 1120..1123
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-2"
FT BINDING 1171
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-2"
FT MOD_RES 1197
FT /note="Phosphotyrosine; by autocatalysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-4"
FT MOD_RES 1198
FT /note="Phosphotyrosine; by autocatalysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-4"
FT MOD_RES 1304
FT /note="Phosphotyrosine; by autocatalysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-4"
FT MOD_RES 1311
FT /note="Phosphotyrosine; by autocatalysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-4"
FT DISULFID 96..99
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT DISULFID 128..136
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT DISULFID 165..168
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT DISULFID 291..360
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT DISULFID 378..399
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT DISULFID 513..531
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT DISULFID 519..553
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT DISULFID 522..538
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
FT DISULFID 534..544
FT /evidence="ECO:0000256|PIRSR:PIRSR000617-3"
SQ SEQUENCE 1343 AA; 150148 MW; 96AEA97FB31E23F7 CRC64;
MVHWTRQWWA CVWFQTVLAF ALANCASLAP NPVNFSVVYT MPFFQAGGPI QNIVNNSFYQ
EVYVASKNVI EAVNRSLEKV WELRTGPVGG SECHICNLCE IDKNHNFPED TDNQVLLLDT
LFMYLYSCGS SQYGVCYFHQ LNPNGEPPSL SKCLFRKGSN SAANCPDCVA SPLGTKVTMV
EEGQTVYFFV AASVNDSVTQ RYGRKSLSVR RPLATEDGFF SDVRGLTVLP SLRKTYHIEY
VYSFFTQEFV YFLSVQRESP DQESSPFQTR LGRLPRNEWE MKRYRELILE CRFEPKRRRR
NVASEPYKDI VYNVVQAAHF GKAGRELAEE LGAEEEDDIL YGVFAVTDDN GVTEHDSALC
AFPMDNVNKA IADGVDDCCE SGPEQLSRGL CHFQPCESCP HESMENNATC RDHPTMVSKP
YYRVDLFNRK MTNVLLTSLL VTTIENKTVA HIGTSTGRLL QLVLTRSSPV IFANYSLVEN
QRVSSIAAVH SSEYLLFVVG DKMIQVPQRG PGCQHFLTCA MCLTAPKFMG CGWCSGVCSW
ESECHNRWRN ESCPPGISGF FPRTAPPDGQ TELTLTGWEF QSPLRPAITS RTHQIRLGQT
SCTVIPAKSN ITHLVCKIRS GATELFKPVN ITVEVHEGKV EGRYSIEGKA EMPGFTFVVP
NITEIQPNYG PRVGGTLITV SGPHLDAGKT RRVTLNDVAL PKGNVSSIIC LSKEISEVRD
VPLSVFIDKS PVLTTKVFYY KENPKITDVR PDCSFDRGSK IVIEGENLDS VYRTIIHFKP
NESHLKSVST ECLGKSLPTR MECMTPVFHR DETVEGSLSF DMDGASSLWS KEFSYHPYGE
PIPFETEGHV LNLYPGFDEV SLHHQKLNLV SSCMTIIMTV AGVDCGAKVL DNEITCRIPK
NMTIPSEGLP VKISINGQVH NVGTVVRVSN HYMVGIVLGI LAALVAGAVL AFVVMKHLRK
KKKASMVESH LTHSANRCGT NNVEMSPVGD YRRGVVSLSP PTPLVGPVAF PSLTYAGGRI
DPTLTPLLPT EKIPITSFRP ELLEEVKDVL IPAEMLVVQK HRIIGKGKEL CTSFWNRITD
VEEVEQFLKE GIIMKGFHHS NVLSLLGVLL PQEGLPLVVL PYMKHGDLRH FIRCEKRNPT
VKDLIGFGLQ VAKGMEYLAQ KKFVHRDLAA RNCMLDESYT VKVADFGMAR DVFDKEYYSV
QDHRKAKLPV KWMAIESLFT AWSFGVLMWE MLTRGASPYP EVDPYDITHY LLKGRRLPQP
QYCPDPLYSI MLQCWDPDPE LRPSFATLVS AVSTILSGLE GEHYISLNVT YVNLDQPHPY
PALTESADEY DSTDVEDSGS MSS
//