ID I3KWU9_ORENI Unreviewed; 771 AA.
AC I3KWU9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=TFIIS central domain-containing protein {ECO:0000259|PROSITE:PS51321};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025595.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000025595.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; I3KWU9; -.
DR STRING; 8128.ENSONIP00000025595; -.
DR Ensembl; ENSONIT00000025616.2; ENSONIP00000025595.2; ENSONIG00000020315.2.
DR eggNOG; KOG1632; Eukaryota.
DR eggNOG; KOG1634; Eukaryota.
DR GeneTree; ENSGT00940000155532; -.
DR InParanoid; I3KWU9; -.
DR OMA; FDGPGKH; -.
DR TreeFam; TF350578; -.
DR Proteomes; UP000005207; Linkage group LG5.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR Gene3D; 1.10.472.30; Transcription elongation factor S-II, central domain; 1.
DR InterPro; IPR012921; SPOC_C.
DR InterPro; IPR003618; TFIIS_cen_dom.
DR InterPro; IPR036575; TFIIS_cen_dom_sf.
DR PANTHER; PTHR11477:SF13; DEATH-INDUCER OBLITERATOR 1; 1.
DR PANTHER; PTHR11477; TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07744; SPOC; 1.
DR Pfam; PF07500; TFIIS_M; 1.
DR SMART; SM00510; TFS2M; 1.
DR SUPFAM; SSF46942; Elongation factor TFIIS domain 2; 1.
DR PROSITE; PS51321; TFIIS_CENTRAL; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 740..767
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 270..390
FT /note="TFIIS central"
FT /evidence="ECO:0000259|PROSITE:PS51321"
FT REGION 1..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 372..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..60
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..118
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..253
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..268
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..458
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 459..508
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 771 AA; 83763 MW; CBA29E7594D1F9FC CRC64;
MKSITDVKEP KQKDKPKAQK KSTLKGTGAG GKKVQKKTQE ESDSEDHSPD PDDDDEDEHA
EEHPPPPATA SWSSDHNYIA VTPEKTTPIS PTVLNKKSPT KEEKHSEKDH KEKEPAPAPE
KSSSASAAAG KGNKKSTATK PTKVSPKGKK PSVQAASSKG SKKPVTPPVK TATKSKKTGQ
PPVNSPSPFP SGPIHVTGAL RVTKSNFTIP KKQPQQKDTS PHRQSSSSLR VPSSPVSSSP
SSHSSSSRPP HSAVSAPPVS PMPPPPNNQM RQNIRRSLTD ILYKRVCDSD DLKMTESEVG
RLAFAIEKEM FNLCLSTDSK YKNKYRSLMF NLKDPKNKGL FYRVVGGEVS PFRLVRLSAE
ELLSKEISEW RKPEAPEVNG TEESGSTPSA SAQASAAEGN SGSSMLDIFS SMLKDTTSEH
RAHLFDLNCK ICTGQKTEDE PAAKKARLTK KPETKPPRQE SFSSRSGDPS PVSQPQAGMA
TYQDPSLYQH PASSSYQSTV EPAVPESQPQ LYQEDVTMMA PAAQAPVPVT PTVSSVTITR
RDPRMARHST GVSVTYVAPE KPGSNVADPL PAPVTAPVEV LSKAPLPMPP APPPSPPPEG
ETAIFLHGQE KIWKGFINMQ SVAKFVTKAY LVSGSFEHLK EDLPDTIHVG GRISPNTVWD
YVGKLKTSLS KELCLIRFHP ATEEEEVAYV SLFSYFSSRK RFGVVANNNR RIKDLYLIPL
GSKDPLPSKL LPFDGPGKHL AVHLGISGLF FFLHIMQLLA VDVSFYIKGV K
//
