ID I3KYH9_ORENI Unreviewed; 615 AA.
AC I3KYH9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 {ECO:0000256|ARBA:ARBA00044113};
GN Name=LINGO1 {ECO:0000313|Ensembl:ENSONIP00000026176.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000026176.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000026176.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
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DR RefSeq; XP_005453158.1; XM_005453101.3.
DR RefSeq; XP_005453159.1; XM_005453102.3.
DR AlphaFoldDB; I3KYH9; -.
DR STRING; 8128.ENSONIP00000026176; -.
DR Ensembl; ENSONIT00000026199.2; ENSONIP00000026176.2; ENSONIG00000020873.2.
DR GeneID; 100700742; -.
DR KEGG; onl:100700742; -.
DR CTD; 564943; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000154996; -.
DR HOGENOM; CLU_000288_18_24_1; -.
DR InParanoid; I3KYH9; -.
DR OMA; MVAREAT; -.
DR OrthoDB; 2911036at2759; -.
DR TreeFam; TF334360; -.
DR Proteomes; UP000005207; Linkage group LG7.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR026906; LRR_5.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR24373:SF31; LEUCINE-RICH REPEAT AND IMMUNOGLOBULIN-LIKE DOMAIN-CONTAINING NOGO RECEPTOR-INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13306; LRR_5; 1.
DR Pfam; PF13855; LRR_8; 2.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00369; LRR_TYP; 11.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..615
FT /note="Leucine-rich repeat and immunoglobulin-like domain-
FT containing nogo receptor-interacting protein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025436747"
FT TRANSMEM 550..575
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 404..503
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 615 AA; 69866 MW; C3D3704CB6A1156E CRC64;
MVGREATGHS YLVAFWQPIL ILMLSTVLSG STTGCPSRCE CNVQERSVMC HRKKLMTVPE
GIPAETRLLD LSKNRIRTIN PDEFANFPNL EHLELSENTI STIEPGAFNN LYGLRILGLR
SNKLKLIQLG VFTGLSNLTQ LDISENKIVI LLDYMFQDLY NLRSLEVGDN DLVFISHRAF
HGLSSLEHLS LEKCNLSSVP TEAFTHLHSL ITLRLRHLNI NVIRDYSFKR LYRLKILEIA
NWPYLDTMTP NCLYGLNLTS LTIANANLTT IPYVALRHLV YLRFLNLSYN PIHTIEGNKL
HDLLRLQEFH LVGGRLAMIE PYSFRGLNYL KILNVSGNSL STLEESAFHS VGNLETLALY
DNPLACDCRL LWVFRRRWRL NFNRQQPTCA SPEFVQGKEF KDFPDVLQPN YFTCRKSRIR
DRKPQQKFVD EGAIVHFACQ ADGDPAPVIM WQSPQKKFIT TKTIGRLSVL PDGTLEVRYA
QIQDNGTYVC IASNAGGNDT SLAHLHIHSY SPDWPHQPNK TFAFISNQPT ETGANDTRAH
APFPFDIKTL IIATTMGFIS FLGVVLFCLV LLFLWSRGKG NTKHNIEIEY VPRKSDAGMS
STTVDAPRKF NMKMI
//
