ID I3KYX3_ORENI Unreviewed; 875 AA.
AC I3KYX3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=SLIT and NTRK like family member 5 {ECO:0000313|Ensembl:ENSONIP00000026320.2};
GN Name=SLITRK5 {ECO:0000313|Ensembl:ENSONIP00000026320.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000026320.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000026320.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SLITRK family.
CC {ECO:0000256|ARBA:ARBA00010439}.
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DR RefSeq; XP_005450064.1; XM_005450007.3.
DR RefSeq; XP_005450065.1; XM_005450008.2.
DR AlphaFoldDB; I3KYX3; -.
DR STRING; 8128.ENSONIP00000026320; -.
DR Ensembl; ENSONIT00000026343.2; ENSONIP00000026320.2; ENSONIG00000021017.2.
DR GeneID; 100691873; -.
DR KEGG; onl:100691873; -.
DR CTD; 26050; -.
DR eggNOG; ENOG502QUVV; Eukaryota.
DR GeneTree; ENSGT00940000158453; -.
DR HOGENOM; CLU_012706_1_0_1; -.
DR InParanoid; I3KYX3; -.
DR OMA; LTGEMFF; -.
DR OrthoDB; 5309131at2759; -.
DR TreeFam; TF326378; -.
DR Proteomes; UP000005207; Linkage group LG23.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007409; P:axonogenesis; IEA:InterPro.
DR GO; GO:1905606; P:regulation of presynapse assembly; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR043326; Slitrk.
DR PANTHER; PTHR45773; SLIT AND NTRK-LIKE PROTEIN 4-RELATED; 1.
DR PANTHER; PTHR45773:SF5; SLIT AND NTRK-LIKE PROTEIN 5; 1.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00369; LRR_TYP; 10.
DR SMART; SM00082; LRRCT; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS51450; LRR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..875
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025363461"
FT TRANSMEM 629..655
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 216..266
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT DOMAIN 540..590
FT /note="LRRCT"
FT /evidence="ECO:0000259|SMART:SM00082"
FT REGION 298..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 736..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 749..764
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 875 AA; 99176 MW; F63157286EC844ED CRC64;
MHIWILKIIL LIASSLRLVE MYDNYGEICR NLCTCEEKEG ILTVSCENRG IIRLTEISPV
QYSMYHLLLT GNLLKKLSVD DFINYTGVTI LHLGNNDISE IESGAFNGLQ GLKRLHLNNN
KIEVLRDETF KGLESLEYLQ IDYNFITNIE SNALSKLHQL TVMILNDNLL SALPPNIFRN
VPLTHLDLRG NRLKMFPYIG LLEHMDKVVE LQLEENPWNC SCELIALKAW LESIAYTALV
GEVVCETPFR LHGRDLDEVS KQELCPRRPL EDTVRPAPPS STNGYYQTTP AAVTASATSS
AVLRSSSRPT KGTRQLNRTR LKPTSRIPGG NPYNYGPIIA FQTKSPVPLD CPTACTCNLQ
ISEIGLNVNC QERKIESISD LKPKPYNPKK MYLTGNYIPV VRRSDFVDAT GLDLLHLGNN
RITLIHDRAF GDLTNLRRLY LNGNLMDRLT GEMFFGLQNL QYLYLEYNKI KEVDAGTFRY
LPNLQLLFLN NNLLKTLPVG IFSSLSLSRL NLRNNHFQNL PVSGVLDQLK LLLQIDLFEN
PWECSCDIVG MKIWLEQLSA GTVVNEVVCE TPKRHTGMDL RSVPSEQLCP DYSEAYVSPT
PPTEEPMDEH VVTTGATRRL DTPGSTVPLS VLILSLLLVF IMSVFVAAGL FVVVMKKRKK
SQSDRTSTNN SDVSSFNLQY SLYSNRSGPK VKAPAGHVYE YIPHPMGHMC KNPIYRSREG
NTVEDYRDLH ELKVTYRSTP DDERDSSTMR SPSYSVSTIE PRENPSPVQD ADHFFRGILE
PDKQSPHQSI PSIPAGANLE YKYTGPVSYT YNPNFDVRRQ FLHPERIRET VLYGTAPSTV
YVEPNRNEYL ELKAKLQSEP DYLEVLEKQT TFSQF
//