ID I3KZW3_ORENI Unreviewed; 612 AA.
AC I3KZW3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Leucine rich repeat and Ig domain containing 3 {ECO:0000313|Ensembl:ENSONIP00000026660.1};
GN Name=lingo3 {ECO:0000313|Ensembl:ENSONIP00000026660.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000026660.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000026660.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005478767.1; XM_005478710.3.
DR RefSeq; XP_005478768.1; XM_005478711.1.
DR RefSeq; XP_005478769.1; XM_005478712.2.
DR RefSeq; XP_013130572.1; XM_013275118.2.
DR AlphaFoldDB; I3KZW3; -.
DR STRING; 8128.ENSONIP00000026660; -.
DR Ensembl; ENSONIT00000026684.2; ENSONIP00000026660.1; ENSONIG00000021358.2.
DR GeneID; 100700578; -.
DR KEGG; onl:100700578; -.
DR CTD; 567293; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000164500; -.
DR HOGENOM; CLU_000288_18_24_1; -.
DR InParanoid; I3KZW3; -.
DR OMA; KLRWVEH; -.
DR OrthoDB; 2911036at2759; -.
DR TreeFam; TF334360; -.
DR Proteomes; UP000005207; Linkage group LG23.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR24373:SF130; LEUCINE-RICH REPEAT AND IMMUNOGLOBULIN-LIKE DOMAIN-CONTAINING NOGO RECEPTOR-INTERACTING PROTEIN 3; 1.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 3.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00365; LRR_SD22; 6.
DR SMART; SM00369; LRR_TYP; 9.
DR SMART; SM00013; LRRNT; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS51450; LRR; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..612
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003675395"
FT TRANSMEM 547..572
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 416..507
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 612 AA; 68075 MW; 2D3DD5705778B76E CRC64;
MATRASLGQD VGWLLPFLFL LLMITVSPAQ SQGCPQRCEC IAKLKTVSCY GKRLSALPDG
IPLDTKILDL SGNKLRWVEH GDLLPYSRLE KLDLSENMIS VLEPNAFSSL QNLKSLSLRG
NQLKLVPMGA FSRLSNLTSL DLSGNKIVIL LDFTFQDLRS LKNLEVGDND LVYISNKAFL
GLVGLKELTI ERCNLTSVSS QSLSYLHNLV TLRLRYLSIS ALEDQNFRKL GNLRGLEIDH
WPFLEYISPH SLQGLNLSWL SITHTNITSV PTSALRSLAH LTSLNLSYNP ITVLESWALR
DLVRLKELHL VKTNLAVVQP YALGGLRQIR LLNLSSNSLV TLEEGAFQSV NTLETLRLDG
NPLACDCRLL WILQRRKTLN FDGASPVCMT PVEVQGRALN AFSDSALFDH FTCQKPKIRN
RKLQQISARE GQVVSFICRA EGEPTPVIFW ISPQRRRITT KSSGRLTVLP EGTLEIRYAQ
VTDSGTYICI ASNAGGNDTY FATLTVSGLP LDAALMANRT YYAGDLNDTN LNDTRVFLKF
TLDLKTILIS TAMGCIMFLG VVLFCFILLF VWSRGRGQHK NNFSVEYSFR KVDGPAASGG
QGGARKFNMK MI
//
