ID I3L162_HUMAN Unreviewed; 190 AA.
AC I3L162;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Chymotrypsin like {ECO:0000313|Ensembl:ENSP00000458598.1};
DE Flags: Fragment;
GN Name=CTRL {ECO:0000313|Ensembl:ENSP00000458598.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000458598.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000458598.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [2] {ECO:0000313|Ensembl:ENSP00000458598.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC040162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3L162; -.
DR SMR; I3L162; -.
DR MEROPS; S01.256; -.
DR MassIVE; I3L162; -.
DR PeptideAtlas; I3L162; -.
DR ProteomicsDB; 46541; -.
DR Antibodypedia; 15944; 220 antibodies from 28 providers.
DR Ensembl; ENST00000571605.1; ENSP00000458598.1; ENSG00000141086.18.
DR UCSC; uc059was.1; human.
DR HGNC; HGNC:2524; CTRL.
DR VEuPathDB; HostDB:ENSG00000141086; -.
DR GeneTree; ENSGT00940000154494; -.
DR HOGENOM; CLU_1431090_0_0_1; -.
DR ChiTaRS; CTRL; human.
DR Proteomes; UP000005640; Chromosome 16.
DR Bgee; ENSG00000141086; Expressed in body of pancreas and 97 other cell types or tissues.
DR ExpressionAtlas; I3L162; baseline and differential.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24250:SF50; CHYMOTRYPSIN-LIKE PROTEASE CTRL-1; 1.
DR PANTHER; PTHR24250; CHYMOTRYPSIN-RELATED; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 1: Evidence at protein level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Proteomics identification {ECO:0007829|PeptideAtlas:I3L162,
KW ECO:0007829|ProteomicsDB:I3L162};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..190
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003674916"
FT DOMAIN 65..190
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT NON_TER 190
FT /evidence="ECO:0000313|Ensembl:ENSP00000458598.1"
SQ SEQUENCE 190 AA; 20164 MW; 2720893C85AE67BE CRC64;
MLLLSLTLSL VLLGSSWGQQ RLPLLRWFSH QPVLGGHCCP LQCQVLSVSR VSAWAADTEE
KWAVQAITHP SWNSTTMNND VTLLKLASPA QYTTRISPVC LASSNEALTE GLTCVTTGWG
RLSGVGNVTP AHLQQVALPL VTVNQCRQYW GSSITDSMIC AGGAGASSCQ GDSGGPLVCQ
KGNTWVLIGI
//
