ID I3L310_HUMAN Unreviewed; 83 AA.
AC I3L310;
DT 29-OCT-2014, integrated into UniProtKB/TrEMBL.
DT 29-OCT-2014, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=N-alpha-acetyltransferase 38, NatC auxiliary subunit {ECO:0000313|Ensembl:ENSP00000460085.1};
GN Name=NAA38 {ECO:0000313|Ensembl:ENSP00000460085.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000460085.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000460085.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000460085.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Auxillary component of the N-terminal acetyltransferase C
CC (NatC) complex which catalyzes acetylation of N-terminal methionine
CC residues. {ECO:0000256|ARBA:ARBA00003350}.
CC -!- SUBUNIT: Component of the N-terminal acetyltransferase C (NatC)
CC complex, which is composed of NAA35, NAA38 and NAA30.
CC {ECO:0000256|ARBA:ARBA00011549}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the snRNP Sm proteins family.
CC {ECO:0000256|ARBA:ARBA00006850}.
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DR EMBL; AC104581; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3L310; -.
DR SMR; I3L310; -.
DR MassIVE; I3L310; -.
DR MaxQB; I3L310; -.
DR PeptideAtlas; I3L310; -.
DR Antibodypedia; 58902; 74 antibodies from 14 providers.
DR Ensembl; ENST00000576384.1; ENSP00000460085.1; ENSG00000183011.14.
DR UCSC; uc060avw.1; human.
DR HGNC; HGNC:28212; NAA38.
DR VEuPathDB; HostDB:ENSG00000183011; -.
DR GeneTree; ENSGT00390000018418; -.
DR HOGENOM; CLU_076902_4_4_1; -.
DR ChiTaRS; NAA38; human.
DR Proteomes; UP000005640; Chromosome 17.
DR Bgee; ENSG00000183011; Expressed in prefrontal cortex and 187 other cell types or tissues.
DR ExpressionAtlas; I3L310; baseline and differential.
DR GO; GO:0031417; C:NatC complex; IEA:InterPro.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR CDD; cd06168; LSMD1; 1.
DR Gene3D; 2.30.30.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR034110; LSMD1_Sm.
DR InterPro; IPR047575; Sm.
DR InterPro; IPR001163; Sm_dom_euk/arc.
DR PANTHER; PTHR10701:SF27; N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT; 1.
DR PANTHER; PTHR10701; SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N; 1.
DR Pfam; PF01423; LSM; 1.
DR SMART; SM00651; Sm; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
DR PROSITE; PS52002; SM; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:I3L310,
KW ECO:0007829|MaxQB:I3L310};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 1..76
FT /note="Sm"
FT /evidence="ECO:0000259|PROSITE:PS52002"
SQ SEQUENCE 83 AA; 8949 MW; 254B5C8E6DCD7811 CRC64;
MRIRMTDGRT LVGCFLCTDR DCNVILGSAQ EFLKPSGQCP GNAHPPDSFS AGEPRVLGLA
MVPGHHIVSI EVQRESLTGP PYL
//
