ID I3L3M9_HUMAN Unreviewed; 152 AA.
AC I3L3M9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Rab effector Noc2 {ECO:0000313|Ensembl:ENSP00000488717.1};
DE SubName: Full=Rabphilin 3A like (without C2 domains) {ECO:0000313|Ensembl:ENSP00000460580.1};
DE Flags: Fragment;
GN Name=RPH3AL {ECO:0000313|Ensembl:ENSP00000460580.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000460580.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000460580.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000460580.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AC108004; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC129507; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC207589; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC211856; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC214012; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC216025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC243301; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR ProteomicsDB; 47273; -.
DR Antibodypedia; 10243; 237 antibodies from 27 providers.
DR Ensembl; ENST00000570638.5; ENSP00000460580.1; ENSG00000181031.16.
DR Ensembl; ENST00000632610.1; ENSP00000488717.1; ENSG00000262334.6.
DR UCSC; uc059yzu.1; human.
DR HGNC; HGNC:10296; RPH3AL.
DR VEuPathDB; HostDB:ENSG00000181031; -.
DR GeneTree; ENSGT00440000034248; -.
DR OMA; AGKRHTW; -.
DR ChiTaRS; RPH3AL; human.
DR Proteomes; UP000005640; Chromosome 17.
DR Bgee; ENSG00000181031; Expressed in body of pancreas and 95 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd15763; FYVE_RPH3L; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR041282; FYVE_2.
DR InterPro; IPR041857; Noc2_FYVE.
DR InterPro; IPR010911; Rab_BD.
DR InterPro; IPR043566; Rabphilin/DOC2/Noc2.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45729:SF4; RAB EFFECTOR NOC2; 1.
DR PANTHER; PTHR45729; RABPHILIN, ISOFORM A; 1.
DR Pfam; PF02318; FYVE_2; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50916; RABBD; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 1: Evidence at protein level;
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|PeptideAtlas:I3L3M9,
KW ECO:0007829|ProteomicsDB:I3L3M9};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 41..152
FT /note="RabBD"
FT /evidence="ECO:0000259|PROSITE:PS50916"
FT DOMAIN 89..146
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT NON_TER 152
FT /evidence="ECO:0000313|Ensembl:ENSP00000460580.1"
SQ SEQUENCE 152 AA; 17334 MW; CDD04F8FC9AB5FB4 CRC64;
MADTIFGSGN DQWVCPNDRQ LALRAKLQTG WSVHTYQTEK QRRKQHLSPA EVEAILQVIQ
RAERLDVLEQ QRIGRLVERL ETMRRNVMGN GLSQCLLCGE VLGFLGSSSV FCKDCRKKVC
TKCGIEASPG QKRPLWLCKI CSEQREVWKR SG
//
