ID I3L412_HUMAN Unreviewed; 196 AA.
AC I3L412;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Beta-arrestin-2 {ECO:0000256|ARBA:ARBA00040110};
DE AltName: Full=Arrestin beta-2 {ECO:0000256|ARBA:ARBA00042805};
DE Flags: Fragment;
GN Name=ARRB2 {ECO:0000313|Ensembl:ENSP00000460879.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000460879.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000460879.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2] {ECO:0000313|Ensembl:ENSP00000460879.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the arrestin family.
CC {ECO:0000256|ARBA:ARBA00005298}.
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DR EMBL; AC091153; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3L412; -.
DR SMR; I3L412; -.
DR MassIVE; I3L412; -.
DR MaxQB; I3L412; -.
DR PeptideAtlas; I3L412; -.
DR ProteomicsDB; 47376; -.
DR Ensembl; ENST00000576235.1; ENSP00000460879.1; ENSG00000141480.18.
DR UCSC; uc059zvn.1; human.
DR HGNC; HGNC:712; ARRB2.
DR VEuPathDB; HostDB:ENSG00000141480; -.
DR GeneTree; ENSGT00950000182887; -.
DR HOGENOM; CLU_033484_2_0_1; -.
DR ChiTaRS; ARRB2; human.
DR Proteomes; UP000005640; Chromosome 17.
DR Bgee; ENSG00000141480; Expressed in granulocyte and 168 other cell types or tissues.
DR ExpressionAtlas; I3L412; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 2.60.40.640; -; 1.
DR Gene3D; 2.60.40.840; -; 1.
DR InterPro; IPR000698; Arrestin.
DR InterPro; IPR014752; Arrestin-like_C.
DR InterPro; IPR011021; Arrestin-like_N.
DR InterPro; IPR017864; Arrestin_CS.
DR InterPro; IPR014753; Arrestin_N.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR11792; ARRESTIN; 1.
DR PANTHER; PTHR11792:SF20; BETA-ARRESTIN-2; 1.
DR Pfam; PF00339; Arrestin_N; 1.
DR PRINTS; PR00309; ARRESTIN.
DR SUPFAM; SSF81296; E set domains; 1.
DR PROSITE; PS00295; ARRESTINS; 1.
PE 1: Evidence at protein level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Proteomics identification {ECO:0007829|EPD:I3L412,
KW ECO:0007829|MaxQB:I3L412};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT DOMAIN 9..163
FT /note="Arrestin-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00339"
FT NON_TER 1
FT /evidence="ECO:0000313|Ensembl:ENSP00000460879.1"
SQ SEQUENCE 196 AA; 22241 MW; 02B100268D5FC19B CRC64;
GGETRDQLTV YLGKRDFVDH LDKVDPVDGV VLVDPDYLKD RKVFVTLTCA FRYGREDLDV
LGLSFRKDLF IATYQAFPPV PNPPRPPTRL QDRLLRKLGQ HAHPFFFTIP QNLPCSVTLQ
PGPEDTGKAC GVDFEIRAFC AKSLEEKSHK RNSVRLVIRK VQFAPEKPGP QPSAETTRHF
LMSDRSLHLE ASLDKE
//
