ID I3L5T2_PIG Unreviewed; 685 AA.
AC I3L5T2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Ubiquitin associated and SH3 domain containing A {ECO:0000313|Ensembl:ENSSSCP00000019382.2};
GN Name=UBASH3A {ECO:0000313|Ensembl:ENSSSCP00000019382.2,
GN ECO:0000313|VGNC:VGNC:94636};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000019382.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000019382.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000019382.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000019382.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; I3L5T2; -.
DR SMR; I3L5T2; -.
DR STRING; 9823.ENSSSCP00000019382; -.
DR PaxDb; 9823-ENSSSCP00000019382; -.
DR Ensembl; ENSSSCT00000027287.4; ENSSSCP00000019382.2; ENSSSCG00000029511.4.
DR VGNC; VGNC:94636; UBASH3A.
DR eggNOG; KOG3734; Eukaryota.
DR GeneTree; ENSGT00940000160841; -.
DR HOGENOM; CLU_016516_0_0_1; -.
DR InParanoid; I3L5T2; -.
DR OMA; CFCEEQK; -.
DR OrthoDB; 5484137at2759; -.
DR TreeFam; TF313334; -.
DR Proteomes; UP000008227; Chromosome 13.
DR Bgee; ENSSSCG00000029511; Expressed in blood and 15 other cell types or tissues.
DR ExpressionAtlas; I3L5T2; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0050860; P:negative regulation of T cell receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0001817; P:regulation of cytokine production; IEA:Ensembl.
DR CDD; cd07067; HP_PGM_like; 1.
DR CDD; cd14300; UBA_UBS3A_like; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR16469; UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED; 1.
DR PANTHER; PTHR16469:SF7; UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING PROTEIN A; 1.
DR Pfam; PF00300; His_Phos_1; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50030; UBA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 81..122
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 300..365
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 381..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..400
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 685 AA; 77392 MW; 0E9B515DBDD48F30 CRC64;
MWKGRHTHTL QREFCKRVSR ANRILAFVRQ ITKGLRFLFS ASGSLPLPLR LYLLRSVCGQ
EEMAAGETQL YAKVTSKLKG RSSSALLEPL LDMGFPAHTA LKALAATGRK TVEEASDWLR
CHCNDPSLDD PIPQEYALFL CPTGPLLDKL QEFWRESKRQ CAKNRAHEVF PHITLCDFFT
CEDQKVECLY EALKRAGDRS LGTFPAAVPL VLHSSVSYLG FFVDDGPADI IREFAVMFAT
EASVLADCTV KPCTKQLHLT LAHKFYPHHQ RTLEQLARAV HPGHSCQWTA ALYSRDMRFV
HYQTLRVLFQ YKPQNVDELT LSLGDYIFVD PTQQEEASEG WVIGISQRTG CRGFLPENYT
ERASECDTWV KHRTYTFSRA LDPGSRKDEA SSRRNGEPHA PHMSRSASSL QSLQASILRR
GVLVVRHGER VDQVFGKSWL QQCSTPDGKY YRPDLNFPRG LPRRSNGIKD FESDPPLSSC
GIFQSRMAGE ALLESGTSIT SVFTSPALRC VQTAKHILEE LKLEKKVKIR VEPGIFEWTK
WEAGKTTPTL MTLEELKEAN FNVSMDYRPA FPLASLLPAE SYNDYVHRCA VSMEQIVSTC
SQDGGVTLIV GHGSALDSCT RPLLRLPPRD CADFGRLVRK IPFLGMCFCE ENKEEGKWEL
VNPPVKTLTH GSNPAFNWRH WVQDN
//
