ID I3L7V5_PIG Unreviewed; 1119 AA.
AC I3L7V5; I3L592;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 4.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Transcription termination factor 2 {ECO:0000313|Ensembl:ENSSSCP00000020113.4};
GN Name=TTF2 {ECO:0000313|Ensembl:ENSSSCP00000020113.4,
GN ECO:0000313|VGNC:VGNC:94563};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000020113.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000020113.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000020113.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000020113.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; I3L7V5; -.
DR STRING; 9823.ENSSSCP00000020113; -.
DR PaxDb; 9823-ENSSSCP00000007181; -.
DR Ensembl; ENSSSCT00000031433.4; ENSSSCP00000020113.4; ENSSSCG00000006733.5.
DR VGNC; VGNC:94563; TTF2.
DR GeneTree; ENSGT00940000162718; -.
DR HOGENOM; CLU_000315_2_2_1; -.
DR InParanoid; I3L7V5; -.
DR OMA; IVSQWTN; -.
DR OrthoDB; 200191at2759; -.
DR Proteomes; UP000008227; Chromosome 4.
DR Bgee; ENSSSCG00000006733; Expressed in mesenteric lymph node and 42 other cell types or tissues.
DR ExpressionAtlas; I3L7V5; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0008094; F:ATP-dependent activity, acting on DNA; IBA:GO_Central.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IBA:GO_Central.
DR CDD; cd18072; DEXHc_TTF2; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR InterPro; IPR010666; Znf_GRF.
DR PANTHER; PTHR45626:SF54; TRANSCRIPTION TERMINATION FACTOR 2; 1.
DR PANTHER; PTHR45626; TRANSCRIPTION TERMINATION FACTOR 2-RELATED; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR Pfam; PF06839; zf-GRF; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51999; ZF_GRF; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01343}.
FT DOMAIN 6..46
FT /note="GRF-type"
FT /evidence="ECO:0000259|PROSITE:PS51999"
FT DOMAIN 540..743
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 949..1114
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 100..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 179..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 831..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..164
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..442
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1119 AA; 125078 MW; 14B44F118D5C8AB5 CRC64;
MEVVRCPQHG TLCFLKTGVR DGPNKGKSFY VCPADTCNFL RATDIPVSHC LLHEGMVVEL
QGLFLPQGKK EYSQQRNPFK VLDKNQEPSL WKQFIKGEDE EKTAHKKQKE KGHPLLDQDN
VQKPESKCWM EKDLSSGLVV KEKPSAVQEK QRGEKTEFQC DTKELEGMHQ RKVFEMKSRQ
VHKDELREPP VSQETANGDS YIRKESEPPR KEETKPLPRT VPSQHPINQP QKGGHLSQEH
PQSWEVRETK TKDDPSCSQT LQKRLLQGHS HAQSETRDVS ALKEPAAQPA PPATRHPRGE
REDVDTSSGD SEEDDVVFVS SEPGSPLLFD LTPDSQKKEN LKFPGQSEQR KISPASGVCK
KGEPLDPAAQ RVHLTAQLKQ KKSTLASVNL QALPDKGQKL FKQIQELEEA LGALALYPEQ
DVNEKRNTQV PQQRNATKTS SDPPHLVPPR PLQGQDLQPL ASLGLKAARQ EIAGGSGQCR
GGPTSQDRLH SVWKVTSEAI DELHRSLESR PDETAVAEDP AGLKVPLLLH QKQALAWLLW
RESQKPPGGI LADDMGLGKT LTMIALILTQ KNQEKNKEKD KTTSSTWLSK TDSSEFTSHR
TLIICPASLI HHWKNEVQKR VCNNELRVYL YHGPNRDQNA KVLSMYDIVI TTYSLLAKEI
PTKEQEGAVP GAELSVQGTA SPLLRIVWAR IILDEAHTVK NPRVQTSMAV CKLQAQARWA
VTGTPIQNNL LDMYSLLKFL RCSPFDEFSL WKSQVDNGSK KGGERLNILT KSLLLRRTKD
QLDSTGKPLV ELPQRQFQLH RLKLSEDEET VYNVLFARSR SDLQSYLKRY ETGDRSSARS
PDNPFNKVAQ EFGSDGPRRP VAGDLQGSST VHILSQLLRL RQCCCHLSLL KSALDPTELK
SEGLVLSLEE QLSALTLSEL HSSESSASVS LNGTCFKVEL FDSMRQSTKI SSLLAELEAI
RRNSGSQKSV IVSQWTSMLE VVALHLKRHR VTYATIDGSV NPKQRMDLVE AFNSSGGPQV
MLISLLAGGV GLNLTGGNHL FLLDMHWNPS LEDQASDRIY RVGQQKDVVI HRFVCEGTVE
EKILQLQEKK KDLAKQILSG SGEFVTKLTL ADLKILFGI
//
