ID I3L837_PIG Unreviewed; 735 AA.
AC I3L837;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 24-JAN-2024, entry version 85.
DE SubName: Full=FYVE, RhoGEF and PH domain containing 3 {ECO:0000313|Ensembl:ENSSSCP00000020195.2};
DE SubName: Full=FYVE, RhoGEF and PH domain-containing protein 3 {ECO:0000313|EMBL:HDC41167.1, ECO:0000313|EMBL:HDC43690.1};
GN Name=FGD3 {ECO:0000313|Ensembl:ENSSSCP00000020195.2,
GN ECO:0000313|VGNC:VGNC:88096};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000020195.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000020195.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000020195.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDC41167.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000020195.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; DQIR01285689; HDC41167.1; -; Transcribed_RNA.
DR EMBL; DQIR01288212; HDC43690.1; -; Transcribed_RNA.
DR STRING; 9823.ENSSSCP00000020195; -.
DR PaxDb; 9823-ENSSSCP00000020195; -.
DR Ensembl; ENSSSCT00000031246.3; ENSSSCP00000020195.2; ENSSSCG00000028185.4.
DR VGNC; VGNC:88096; FGD3.
DR eggNOG; KOG4424; Eukaryota.
DR GeneTree; ENSGT00940000159597; -.
DR HOGENOM; CLU_011755_1_1_1; -.
DR OMA; RITGEWE; -.
DR OrthoDB; 5385125at2759; -.
DR TreeFam; TF316247; -.
DR Reactome; R-SSC-193648; NRAGE signals death through JNK.
DR Reactome; R-SSC-416482; G alpha (12/13) signalling events.
DR Reactome; R-SSC-9013148; CDC42 GTPase cycle.
DR Proteomes; UP000008227; Chromosome 3.
DR Bgee; ENSSSCG00000028185; Expressed in blood and 40 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007010; P:cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0046847; P:filopodium assembly; IBA:GO_Central.
DR CDD; cd15740; FYVE_FGD3; 1.
DR CDD; cd13387; PH1_FGD3; 1.
DR CDD; cd13236; PH2_FGD1-4; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR035941; FGD1-4_PH2.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF14; FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 1: Evidence at protein level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Proteomics identification {ECO:0007829|PeptideAtlas:I3L837};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 167..351
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 380..479
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 542..598
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 626..727
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 601..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..163
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..548
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 735 AA; 80249 MW; 6C9DA719DFD636E5 CRC64;
MEPGGGSSMP PAPIAALGEP DAGPSSSSLE LPSTDPGKLQ ALPVGPGVHC GDPASGSPDS
QVSVGDSPQD MGSIGEPSSS TKIPNRDSGI DSPSCSVVSE HFPCEEGSEA APGPTIKGLH
PETASEGTTP REEADSDVGE GSSEEPEAEN SRPRADADPA KCSKPQKLLH IAQELLHTEE
TYVKRLHLLD QVFCTQLTEA GIPSEVTTGI FSNISSIYRF HGQFLLPELQ TRITTEWDTN
PRLGDILQKL APFLKMYGEY VKNFDRAVEL VSTWTQRSPL FKDIVQGIQK QEMCGNLTLQ
HHMLEPVQRV PRYELLLKDY LKRLPEDAPD WKDAERSLEL ISTAANHSNA AIRKMEKMHK
LLEVYERLGG EEDIVNPANE LIKEGHIQKL SAKNGTAQDR HLFLFNSMIL YCVPKLRLMG
QKFSVREKMD ISGLQVQDSI KPNSAHTFII TGKKRSLELQ TRTEEEKKEW IQVIEATIEK
HKQNSQTFKA FSGSFGQDED SSFTADPPMV NTSSEVPAVV ASGGGGAAGL EPRRASSRTR
RDKEKQGCRS CGETFNSITK RKHHCKLCGA VICGKCSEFK AENGRQSRVC RECFLTQPAA
PLNPSPDVPL EPKQSTEKPA AVDHPPSLLC GPLQVSDGST AWSKVWAAIP ESGPPELVLR
LHGGSQDGQL LCAIPLSGCR VSVPDPADRL DARHMWRLQQ GQQCWCLSAP SVELQQQWLE
ALSMAARRPP ALAAP
//