ID I3LCA7_PIG Unreviewed; 233 AA.
AC I3LCA7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=RAB20, member RAS onco family {ECO:0000313|Ensembl:ENSSSCP00000021682.1};
DE SubName: Full=Ras-related protein Rab-20 {ECO:0000313|EMBL:HDC06921.1};
GN Name=RAB20 {ECO:0000313|Ensembl:ENSSSCP00000021682.1,
GN ECO:0000313|VGNC:VGNC:98243};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000021682.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000021682.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000021682.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDC06921.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000021682.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000256|ARBA:ARBA00006270}.
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DR EMBL; DQIR01251443; HDC06921.1; -; Transcribed_RNA.
DR RefSeq; XP_003482979.1; XM_003482931.3.
DR STRING; 9823.ENSSSCP00000021682; -.
DR PaxDb; 9823-ENSSSCP00000021682; -.
DR Ensembl; ENSSSCT00000026731.4; ENSSSCP00000021682.1; ENSSSCG00000022719.4.
DR GeneID; 100737446; -.
DR KEGG; ssc:100737446; -.
DR CTD; 55647; -.
DR VGNC; VGNC:98243; RAB20.
DR eggNOG; KOG0092; Eukaryota.
DR GeneTree; ENSGT00940000161024; -.
DR HOGENOM; CLU_041217_12_0_1; -.
DR OMA; YNIAIWD; -.
DR OrthoDB; 3910590at2759; -.
DR TreeFam; TF331574; -.
DR Proteomes; UP000008227; Chromosome 11.
DR Bgee; ENSSSCG00000022719; Expressed in heart and 36 other cell types or tissues.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0045335; C:phagocytic vesicle; IEA:Ensembl.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0071346; P:cellular response to type II interferon; IEA:Ensembl.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0090383; P:phagosome acidification; IEA:Ensembl.
DR GO; GO:0090385; P:phagosome-lysosome fusion; IEA:Ensembl.
DR CDD; cd04126; Rab20; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041836; Rab20.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR24073; DRAB5-RELATED; 1.
DR PANTHER; PTHR24073:SF941; RAS-RELATED PROTEIN RAB-20; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
FT REGION 119..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 233 AA; 25261 MW; 534FD49F3965CC51 CRC64;
MRKPDGKIVL LGDMNVGKTS LLQRYMERRF PDTVSTVGGA FYLKQWRSYN ISIWDTAGRE
QFHGLGSMYC RGAAAVILTY DVNHAQSLLE LEDRFLGLTD TASADCLFAI VGNKVDLSEE
GPGDGGQDGG HGPGPAGVGA APRLPKQVQP EDAVALYKKI LKYKMLDEKD VPAAEQMCFE
TSAKTGHNVD LLFETLFDMV VPVILRQRAQ GPPQTVDIAP CGPPARTRSG CCA
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