ID I3LDG3_PIG Unreviewed; 347 AA.
AC I3LDG3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Ankyrin repeat and SOCS box containing 5 {ECO:0000313|Ensembl:ENSSSCP00000022094.2};
GN Name=ASB5 {ECO:0000313|Ensembl:ENSSSCP00000022094.2,
GN ECO:0000313|VGNC:VGNC:95834};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000022094.2, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000022094.2, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000022094.2,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000022094.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR AlphaFoldDB; I3LDG3; -.
DR SMR; I3LDG3; -.
DR STRING; 9823.ENSSSCP00000022094; -.
DR Ensembl; ENSSSCT00000023661.4; ENSSSCP00000022094.2; ENSSSCG00000030395.4.
DR VGNC; VGNC:95834; ASB5.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000159851; -.
DR HOGENOM; CLU_000134_4_1_1; -.
DR InParanoid; I3LDG3; -.
DR TreeFam; TF331945; -.
DR Reactome; R-SSC-8951664; Neddylation.
DR Reactome; R-SSC-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000008227; Chromosome 15.
DR Bgee; ENSSSCG00000030395; Expressed in psoas major muscle and 35 other cell types or tissues.
DR ExpressionAtlas; I3LDG3; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0045732; P:positive regulation of protein catabolic process; IBA:GO_Central.
DR GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR24136:SF18; ANKYRIN REPEAT AND SOCS BOX PROTEIN 5; 1.
DR PANTHER; PTHR24136; SOWAH (DROSOPHILA) HOMOLOG; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 35..61
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 87..119
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 120..152
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 153..185
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 250..282
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 295..347
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
SQ SEQUENCE 347 AA; 38519 MW; 379F363CFCE51E97 CRC64;
PAGIFFPQDQ LFRSIPDRSQ AHRRLGSNRR QLSNVYFTIL SLFCFKLFVK ISLAILSHFY
IVKGNRKEAA RIAAEFYGVT QGQGSWADRS PLHEAASQGR LLALRTLLSQ GYNVNAVTID
HVTPLHEACL GDHVACARTL LQAGANVNAI TIDGVTPLFN ACSRGSRSCT ELLLEYGAKP
QLESCLPSPT HEAASKGHHE CLEILISWGI DVDQDIPHLG TPLYVACMSQ QFHCIRKLLY
AGADVQKGKY WDTPLHAAAQ QSCPEIVNLL LEFGADINAK NTELLRPIDV ATSSSLVERL
LLQHEATPSS LCQLCRLCIR NYIGRARLHL IPQLQLPTLL QNFLQYR
//
