ID   I3LH47_PIG              Unreviewed;       500 AA.
AC   I3LH47;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   27-MAR-2024, entry version 66.
DE   SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 3 {ECO:0000313|Ensembl:ENSSSCP00000023392.2};
GN   Name=ENTPD3 {ECO:0000313|Ensembl:ENSSSCP00000023392.2,
GN   ECO:0000313|VGNC:VGNC:87715};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000023392.2, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000023392.2, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000023392.2,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000023392.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC       {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR   AlphaFoldDB; I3LH47; -.
DR   SMR; I3LH47; -.
DR   STRING; 9823.ENSSSCP00000023392; -.
DR   PaxDb; 9823-ENSSSCP00000023392; -.
DR   Ensembl; ENSSSCT00000028217.3; ENSSSCP00000023392.2; ENSSSCG00000025783.3.
DR   VGNC; VGNC:87715; ENTPD3.
DR   eggNOG; KOG1386; Eukaryota.
DR   GeneTree; ENSGT01100000263542; -.
DR   HOGENOM; CLU_010246_2_3_1; -.
DR   InParanoid; I3LH47; -.
DR   OMA; GNAISDM; -.
DR   OrthoDB; 180318at2759; -.
DR   TreeFam; TF332859; -.
DR   Reactome; R-SSC-8850843; Phosphate bond hydrolysis by NTPDase proteins.
DR   Proteomes; UP000008227; Chromosome 13.
DR   Bgee; ENSSSCG00000025783; Expressed in medulla oblongata and 37 other cell types or tissues.
DR   ExpressionAtlas; I3LH47; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004382; F:GDP phosphatase activity; IBA:GO_Central.
DR   GO; GO:0017111; F:ribonucleoside triphosphate phosphatase activity; IEA:Ensembl.
DR   GO; GO:0045134; F:UDP phosphatase activity; IBA:GO_Central.
DR   GO; GO:0009134; P:nucleoside diphosphate catabolic process; IBA:GO_Central.
DR   GO; GO:0009143; P:nucleoside triphosphate catabolic process; IEA:Ensembl.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 1.
DR   Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR   InterPro; IPR000407; GDA1_CD39_NTPase.
DR   PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR   PANTHER; PTHR11782:SF38; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 3; 1.
DR   Pfam; PF01150; GDA1_CD39; 1.
DR   PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU003833};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..43
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   ACT_SITE        182
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT   BINDING         222..226
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ   SEQUENCE   500 AA;  55830 MW;  CA87F68B44D01367 CRC64;
     MFTVLTRQPC EQAGFKALSR TSAIIALVVL LLSIAVLVAI TLIQIHQREV LLPGLKYGIV
     LDAGSSRTTV YVYQWPAEKE NNTGVVSQTF KCSVKGSGIS SYAENPQDVP KAFEDCMQKV
     KGQIPAHLHG STCIYLGATA GMRLLRLQNE TAANEVLASI QNYFESQPFD FRGAQIISGQ
     EEGIYGWITA NYLMGNFLEK SLWHMWVHPN GVETTGALDL GGASTQISFA AEEKVGLNTS
     DIMKVSLYGY EYTLYTHSFQ CYGRNEAEKR FLALLQESST ETTFTNPCYP RNYNTTFTSA
     HVFGSLCTVD LRPETYDPDN IITFEGTGDP SLCREKVASL FNFKACHDQE ACSFNGVYQP
     KVKGSFVAFA GFYYTASAFN LSGSFSLHTF NSSMWNFCSQ NWSQLPLLLP RFDEEYARSY
     CFSAHYIYHL LVNGYKFTED TWPQIHFKKE VGNSSIAWSL GYMLSLTNQI PAESPLIRLP
     IKPSAFMGIL ASLQQWPCCV
//