ID I3LIR7_PIG Unreviewed; 531 AA.
AC I3LIR7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Cytochrome P450 family 4 subfamily F member 22 {ECO:0000313|Ensembl:ENSSSCP00000023974.1};
GN Name=CYP4F22 {ECO:0000313|Ensembl:ENSSSCP00000023974.1,
GN ECO:0000313|VGNC:VGNC:103360};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000023974.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000023974.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000023974.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000023974.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family.
CC {ECO:0000256|ARBA:ARBA00010617, ECO:0000256|RuleBase:RU000461}.
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DR RefSeq; XP_003354173.1; XM_003354125.2.
DR AlphaFoldDB; I3LIR7; -.
DR SMR; I3LIR7; -.
DR STRING; 9823.ENSSSCP00000023974; -.
DR PaxDb; 9823-ENSSSCP00000023974; -.
DR Ensembl; ENSSSCT00000024967.4; ENSSSCP00000023974.1; ENSSSCG00000023607.4.
DR GeneID; 100620265; -.
DR KEGG; ssc:100620265; -.
DR CTD; 126410; -.
DR VGNC; VGNC:103360; CYP4F22.
DR eggNOG; KOG0157; Eukaryota.
DR GeneTree; ENSGT00940000161507; -.
DR HOGENOM; CLU_001570_5_1_1; -.
DR InParanoid; I3LIR7; -.
DR OMA; QQMHLFS; -.
DR OrthoDB; 1611592at2759; -.
DR TreeFam; TF105088; -.
DR Reactome; R-SSC-211935; Fatty acids.
DR Reactome; R-SSC-211979; Eicosanoids.
DR Reactome; R-SSC-2142691; Synthesis of Leukotrienes (LT) and Eoxins (EX).
DR Proteomes; UP000008227; Chromosome 2.
DR Bgee; ENSSSCG00000023607; Expressed in oocyte and 2 other cell types or tissues.
DR ExpressionAtlas; I3LIR7; baseline and differential.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR GO; GO:0046513; P:ceramide biosynthetic process; IBA:GO_Central.
DR CDD; cd20679; CYP4F; 1.
DR Gene3D; 1.10.630.10; Cytochrome P450; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR PANTHER; PTHR24291; CYTOCHROME P450 FAMILY 4; 1.
DR PANTHER; PTHR24291:SF53; ULTRA-LONG-CHAIN FATTY ACID OMEGA-HYDROXYLASE; 1.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; Cytochrome P450; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 3: Inferred from homology;
KW Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|RuleBase:RU000461};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000461};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000461};
KW Monooxygenase {ECO:0000256|RuleBase:RU000461};
KW Oxidoreductase {ECO:0000256|RuleBase:RU000461};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 531 AA; 62006 MW; AFFC0DC0E7ECC112 CRC64;
MLPITEYILH LLGLEKTAFR VYALSGLLLS LLFFLFRLLL QFLRFCWCFY ITCRRLRCFP
QPPRRNWLLG HLGMYLPNEM GLRAEKKVLD NMHHVILVWI GPVLPLLVLV HPDYIKPVVG
ASAAIAPKDD LFYGFLKPWL GDGLLLSKGD KWSRHRRMLT PAFHFDILKP YMKIFNQCTN
IMHAKWRRLA EGSVVSLDMF EHVSLMTLDS LQKCVFSYNS NCQEKMSDYI SAIIQLSALV
VQRQYRLHLH IDFIYYCTAE GRRFRKACDT VHRFTTEVIQ ERRRALRQQG AEAWLKAKQG
KNLDFIDVLL LARDEDGKEL SDEDIRAEAD TFMFEGHDTT SSGLSWVLFN LAKYPEYQEK
CREEIQEVMK GRELEELEWD DLTQLPFTTM CIKESLRQFP PVTLVTRRCT EDIKLPDGRV
IPKGIICLIS IYGIHYNPRV WPDSKVYNPY RFDPDNPQER SALAYLPFSA GPRNCIGQNF
AMAEMRVAVA LTLLRFRLSV DRTHKVRRKP ELILRTENGI WLKVEPLPPR A
//
