ID I3LLP1_PIG Unreviewed; 1564 AA.
AC I3LLP1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=ATP binding cassette subfamily A member 8 {ECO:0000313|Ensembl:ENSSSCP00000025011.3};
GN Name=ABCA8 {ECO:0000313|Ensembl:ENSSSCP00000025011.3,
GN ECO:0000313|VGNC:VGNC:110641};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000025011.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000025011.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000025011.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000025011.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR PeptideAtlas; I3LLP1; -.
DR Ensembl; ENSSSCT00000031089.4; ENSSSCP00000025011.3; ENSSSCG00000026473.4.
DR VGNC; VGNC:110641; ABCA8.
DR eggNOG; KOG0059; Eukaryota.
DR GeneTree; ENSGT00940000162012; -.
DR HOGENOM; CLU_000604_19_1_1; -.
DR TreeFam; TF105192; -.
DR Proteomes; UP000008227; Chromosome 12.
DR Bgee; ENSSSCG00000026473; Expressed in liver and 39 other cell types or tissues.
DR ExpressionAtlas; I3LLP1; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd03263; ABC_subfamily_A; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229:SF148; ABC-TYPE ORGANIC ANION TRANSPORTER ABCA8; 1.
DR PANTHER; PTHR19229; ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA; 1.
DR Pfam; PF12698; ABC2_membrane_3; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 1: Evidence at protein level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Proteomics identification {ECO:0007829|PeptideAtlas:I3LLP1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 232..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 267..292
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..358
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 801..822
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 961..983
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1003..1026
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1038..1068
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1080..1099
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1106..1133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1145..1165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 419..654
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1230..1461
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 1564 AA; 176346 MW; CD64DF19BA0F8C34 CRC64;
MDLGQVDSFN ASQSEIAYTP VTNTTLQIMN IVASASFMKD TEVLGLSNEE SIKKLTADHP
EEIIGVIFTD TFAYHLKFSP GHRIPVRKEH MDHTAHCYEM NEAVDCEVSE FWKKGFVAVQ
AAINAAIIEF TTNQSVMEQL MSVTGKNMKI HPFISQGGIA TDVFIFFCVI SFAPFTYYAS
INVTRERKKM KGLMTMMGLR DSAFWLSWGL LYAGFIFIMA LFLTLIVKSA QFIILSGFVV
IFALFLLYGL SLIALTFLMS VLVKKSFLTG LTVFLLTVFC GSLGFMALYR YLPASLEWIL
SFLSPFAFML GMTQLLRSDY DLNSNALLDA SDSSNLIIAT NFVLTFDIFF YLALAIYFDR
ILSSEYGHRY SPLFFLKSSF RSKQQRTDHI ALEDELDSNP SSNDSFEPMS PEFHGKEAIR
IRNVTKEYKG KPDKIEALKD LAFDIYEGQI TAILGHSGAG KSTLLNILSG LSVPTKGSVT
IYDNKLSQTA YLENISKLTG VCPQINVQFD FLTVRENLRL FAKIKGIQPH EIDKEVQRVL
LELEMKNIQD ILAQNLSGGQ KRKLTFGIAI LGDPQIFLLD EPTAGLDPFS RHQVWNILKE
RKTDRVILFS TQFMDEADIL ADRKVFLSKG RLKCAGSSLF LKKKWGIGYH LSLQLNEMCV
QEKITSLVKQ HIPDAKLSAE SEGKLVYTLP LERTHKFPEL YEDLDRCPGL GIENYGVSMT
TLNEVFLKLE GKSSLDESDS ANLGEVPAER SGDTERLVEM EQYLSLLNEP RQTISGLALW
GQQIRAIGRV RLLKLKHERK ALLSLLLILV VGFCPLLLEY IIMKIHQNSY TWELSPDLYF
LAPGQQPRDP LTQLLIINKT GASIDDFIHA VENQNIALEV DVLGTRNGLD DPSYNGAIIV
SGSEKNYSFS LACNTKRLTC FPVLMDIVSN GLLGLAEPSA HIQTERSTFL EKDQDNSFES
LGYTMFWLTL SSCCAPYIAM SSIDDYKNKA RSQLRISGLS PSAYWFGQAL VDVPMYCLIF
VFMYLMSYSL SLQDGLNIYN LFGVIIWIIQ IPCTFGYATS LIFLTYVISF IFRKGKKNSG
IWSFCFYIIT ILAVLGLLFD DSEHSALYAI AFLIPQATLI GYLFLVFHFS MFYYLDEESR
TIEPFLVSLI PFLHFITFLF ILRCLEWKFG KTSMRKDPFF RISPRRSDVC PNPEEPEGED
EDVQMERRRT ADALNSTNFD EKPVIIASCL RKEYTGKRKR CLSKRKKKIA ARHVSFCVRK
GEVLGLLGHN GAGKSTSIKV ITGDTKPTAG QVLLKGSSGG DPLGFLGYCP QENALWPSLT
VKEHLEVFAA VKGLRKADAA AAIARLVDAL KLQDQLKLPT KALSEGIKRK LCFALSILGN
PSVVLLDEPS TGMDPEGQQQ MWQAIRATFK NTERGALLTT HYMAEAEAVC DRFVAVKASA
CIGAIQHLKN KFGKNYLLEM KVKTPTQEET LHSEILRLFP QAARQERFSS LMVYKLPVED
VRPLAQAFFK LENVKQRFDL EEYSLSQSTL EQVFLELSKE QELDDLKEEL HPSVKWKLLP
QEEP
//
