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Database: UniProt
Entry: I3LQB5_PIG
LinkDB: I3LQB5_PIG
Original site: I3LQB5_PIG 
ID   I3LQB5_PIG              Unreviewed;       576 AA.
AC   I3LQB5;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-SEP-2017, entry version 39.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSSCP00000026293};
GN   Name=KCNA5 {ECO:0000313|Ensembl:ENSSSCP00000026293};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000026293, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000026293, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000026293};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000026293}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSSCP00000026293}.
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DR   EMBL; CU582813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9823.ENSSSCP00000026293; -.
DR   PaxDb; I3LQB5; -.
DR   Ensembl; ENSSSCT00000023232; ENSSSCP00000026293; ENSSSCG00000021596.
DR   eggNOG; KOG1545; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00760000118846; -.
DR   InParanoid; I3LQB5; -.
DR   OMA; LPRNEFQ; -.
DR   TreeFam; TF313103; -.
DR   Reactome; R-SSC-1296072; Voltage gated Potassium channels.
DR   Proteomes; UP000008227; Chromosome 5.
DR   Bgee; ENSSSCG00000021596; -.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0014704; C:intercalated disc; IEA:Ensembl.
DR   GO; GO:0045121; C:membrane raft; IEA:Ensembl.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:Ensembl.
DR   GO; GO:0051393; F:alpha-actinin binding; IEA:Ensembl.
DR   GO; GO:0005251; F:delayed rectifier potassium channel activity; IEA:Ensembl.
DR   GO; GO:0015271; F:outward rectifier potassium channel activity; IEA:Ensembl.
DR   GO; GO:0019870; F:potassium channel inhibitor activity; IEA:Ensembl.
DR   GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR   GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0086089; F:voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization; IEA:Ensembl.
DR   GO; GO:0086087; F:voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization; IEA:Ensembl.
DR   GO; GO:0086090; F:voltage-gated potassium channel activity involved in SA node cell action potential repolarization; IEA:Ensembl.
DR   GO; GO:0060081; P:membrane hyperpolarization; IEA:Ensembl.
DR   GO; GO:0098914; P:membrane repolarization during atrial cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0043267; P:negative regulation of potassium ion transport; IEA:Ensembl.
DR   GO; GO:0007219; P:Notch signaling pathway; IEA:Ensembl.
DR   GO; GO:0071435; P:potassium ion export; IEA:Ensembl.
DR   GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   GO; GO:0060372; P:regulation of atrial cardiac muscle cell membrane repolarization; IEA:Ensembl.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR   GO; GO:0019229; P:regulation of vasoconstriction; IEA:Ensembl.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR   InterPro; IPR003972; K_chnl_volt-dep_Kv1.
DR   InterPro; IPR004052; K_chnl_volt-dep_Kv1.5.
DR   InterPro; IPR011333; SKP1/BTB/POZ.
DR   InterPro; IPR003131; T1-type_BTB.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR11537; PTHR11537; 1.
DR   PANTHER; PTHR11537:SF199; PTHR11537:SF199; 1.
DR   Pfam; PF02214; BTB_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01512; KV15CHANNEL.
DR   PRINTS; PR01491; KVCHANNEL.
DR   PRINTS; PR01496; SHAKERCHANEL.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008227};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00091688}.
FT   TRANSMEM    211    232       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    397    418       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    458    479       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       80    180       BTB. {ECO:0000259|SMART:SM00225}.
SQ   SEQUENCE   576 AA;  63622 MW;  09FB161753102AC7 CRC64;
     XGGEFRCPPT VRFGDGPKER EPRGRGAERR ADPGGRPVPP PPQELPQSRW LPPEEEEGDG
     DPALGVAEDQ VLGAGSLHHQ RVLINISGLR FETQLGTLAQ FPNTLLGDPA KRLRYFDPLR
     NEYFFDRNRP SFDGILYYYQ SGGRLRRPVN VSLDVFADEI RFYQLGDEAM ERFREDEGFI
     KEEEKPLPRN EFQRQVWLIF EYPESSGSAR AIAIVSVLVI LISIITFCLE TLPEFRDERE
     LLRHPPVHHQ PPGPAPGANG SGAAAAPPPS GPTVAPLLPR TLADPFFIVE TTCVVWFTFE
     LLVRFFACPS KAEFSRNIMN IIDVVAIFPY FITLGTELVE QQPGGGGGGG QNGQQAMSLA
     ILRVIRLVRV FRIFKLSRHS KGLQILGKTL QASMRELGLL IFFLFIGVIL FSSAVYFAEA
     DNQETHFSSI PDGFWWAVVT MTTVGYGDMR PVTVGGKIVG SLCAIAGVLT IALPVPVIVS
     NFNYFYHRET DHEEQAALKE EQGSQSQGTG LASGGQRKAS WSKGSLCKAV GALDNADGSR
     RGSCPLEKCN LKAKSNVDLR RSLYALCLDS SRETDL
//
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