ID I3LY74_ICTTR Unreviewed; 1027 AA.
AC I3LY74;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=SMARCAD1 {ECO:0000313|Ensembl:ENSSTOP00000001100.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000001100.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000001100.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC {ECO:0000256|ARBA:ARBA00007025}.
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DR EMBL; AGTP01094246; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005337612.1; XM_005337555.1.
DR RefSeq; XP_013219358.1; XM_013363904.1.
DR AlphaFoldDB; I3LY74; -.
DR STRING; 43179.ENSSTOP00000001100; -.
DR Ensembl; ENSSTOT00000001228.3; ENSSTOP00000001100.3; ENSSTOG00000001227.3.
DR GeneID; 101966557; -.
DR CTD; 56916; -.
DR eggNOG; KOG0389; Eukaryota.
DR GeneTree; ENSGT00910000144252; -.
DR HOGENOM; CLU_000315_17_8_1; -.
DR InParanoid; I3LY74; -.
DR OrthoDB; 5482994at2759; -.
DR TreeFam; TF105768; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0000792; C:heterochromatin; IEA:Ensembl.
DR GO; GO:0043596; C:nuclear replication fork; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0035861; C:site of double-strand break; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0051304; P:chromosome separation; IEA:Ensembl.
DR GO; GO:0000729; P:DNA double-strand break processing; IEA:Ensembl.
DR GO; GO:0000018; P:regulation of DNA recombination; IEA:Ensembl.
DR CDD; cd17998; DEXHc_SMARCAD1; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR003892; CUE.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR049730; SNF2/RAD54-like_C.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR10799; SNF2/RAD54 HELICASE FAMILY; 1.
DR PANTHER; PTHR10799:SF964; SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A CONTAINING DEAD_H BOX 1; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51140; CUE; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 157..199
FT /note="CUE"
FT /evidence="ECO:0000259|PROSITE:PS51140"
FT DOMAIN 251..294
FT /note="CUE"
FT /evidence="ECO:0000259|PROSITE:PS51140"
FT DOMAIN 510..678
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 859..1011
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 359..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 223..241
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1027 AA; 117301 MW; FE192BBC69EB4E22 CRC64;
MNLFNLDRFR FEKRSKIEEA PEATPQPSQP GPSSPISLSA EEENAEGEVS RANTPDSDIT
EKTEDSSVPE TPDNERKASI SHFKNQRGIQ YIDLSSDSED VVSPNCSSTV QEKKFNKDTV
IIVSEPSEDE ESQGLPTVAQ RNDDISELED LSELEDLKDA KLQTLKELFP QRSDNDLLKL
IESTSTMDGA IAAALLMFGD AGGGPRKRKL SSSSEPYEED EFNEDQSLKK TRLDHGEESN
ESAESSSNWE KQESIVLKLQ KEFPNFDKQE LREVLKEHEW MYTEALESLK VFAEDQDTSQ
FSSQSEVPNG KEVSSRSQNC PKNVAKTKLK QKFSMKQQNG FNKKRKKNVF NPKKVIEDSE
YDSGSDVGSS LDEDYSSGEE MMEDGYKGKI LHFLQDASIG ELTLIPQCSQ KKAQKITELR
PFNSWEALFT KMSKTNGLSE DLIWNCKTLI QERDVVIRLM NKCEDISNKL TKQVTMLTGN
GGGWNIEQPS ILNQSLSLKP YQKVGLNWLA LVHKHGLNGI LADEMGLGKT IQAIAFLAYL
YQEGNKGPHL IVVPASTIDN WLREVNLWCP TLNVLCYYGS QEERKQIRFN IHSKYEDYNV
IVTTYNCAIS SSDDRSLFRR LKLNYAIFDE GHMLKNMGSI RYQHLMTINA NNRLLLTGTP
VQNNLLELMS LLNFVMPHMF SSSTSEIRRM FSSKTKSADE QSIYEKERIA HAKQIIKPFI
LRRVKEEVLK QLPPKKDQIE LCAMSEKQEQ LYLGLFNRMK KSINNMEKNT EMCNVMMQLR
KMANHPLLHR QYYTAEKLKE MSQLMLKEPT HCEANPDLIF EDMEVMTDFE LHVLCKQYRH
INNFQLDMDL ILDSGKFRVL GCILSELKQK GNRVVLFSQF TMMLDILEVL LKHHQHRYLR
LDGKTQISER IHLIDEFNTD MDIFVFLLST KAGGLGINLT SANVVILHDI DCNPYNDKQA
EDRCHRVGQT KEVLVIKLIS QGTIEESMLK INQQKLKLEQ DMTTVDEGDE GSMPADIATL
LKTSMGL
//
