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Database: UniProt
Entry: I3LYG8_ICTTR
LinkDB: I3LYG8_ICTTR
Original site: I3LYG8_ICTTR 
ID   I3LYG8_ICTTR            Unreviewed;       742 AA.
AC   I3LYG8;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   07-JUN-2017, entry version 37.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel)
OS   (Spermophilus tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha;
OC   Sciuridae; Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000001234, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Ensembl:ENSSTOP00000001234}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000001234}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSTOP00000001234}.
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DR   EMBL; AGTP01000237; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01000238; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01000239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01000240; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01000241; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01000242; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 43179.ENSSTOP00000001234; -.
DR   Ensembl; ENSSTOT00000001376; ENSSTOP00000001234; ENSSTOG00000001367.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; I3LYG8; -.
DR   OMA; CISMAFE; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR008051; Na_channel_a1su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   Pfam; PF00520; Ion_trans; 2.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01664; NACHANNEL1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005215};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     20     40       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     69     95       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    193    217       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    275    293       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    305    323       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    335    355       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    392    420       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    496    519       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN        1    225       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      274    529       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   742 AA;  84841 MW;  D3F5C89D42C72FA2 CRC64;
     MLLKWVAYGY QTYFTNAWCW LDFLIVDVSL VSLTANALGY SELGAIKSLR TLRALRPLRA
     LSRFEGMRVV VNALLGAIPS IMNVLLVCLI FWLIFSIMGV NLFAGKFYHC VNTTTGDMFE
     ISEVNNHSDC LKLIERNETA RWKNVKVNFD NVGFGYLSLL QVATFKGWMD IMYAAVDSRN
     VELQPKYEES LYMYLYFVIF IIFGSFFTLN LFIGVIIDNF NQQKKKISQD IFMTEEQKKY
     YNAMKKLGSK KPQKPIPRPG NKFQGMVFDF VTRQVFDISI MILICLNMVT MMVETDDQSE
     YVTNILSRIN LVFIVLFTGE CVLKLISLRH YYFTIGWNIF DFVVVILSIV GMFLAELIEK
     YFVSPTLFRV IRLARIGRIL RLIKGAKGIR TLLFALMMSL PALFNIGLLL FLVMFIYAIF
     GMSNFAYVKR EVGIDDMFNF ETFGNSMICL FQITTSAGWD GLLAPILNSK PPDCDPKKDN
     PGSSVKGDCG NPSVGIFFFV SYIIISFLVV VNMYIAVILE NFSVATEESA EPLSEDDFEM
     FYEVWEKFDP DATQFMEFEK LSQFAAALEP PLNLPQPNKL QLIAMDLPMV SGDRIHCLDI
     LFAFTKRVLG ESGEMDALRI QMEERFMASN PSKVSYQPIT TTLKRKQEEV SAVIIQRAYR
     RHLLKRTVKQ ASFAYNKNKL KGGANLLVKE DMIIDRINEN SITEKTDLTM STAVCPPSYD
     RVTKPIVEKH EQEGKDEKAK GK
//
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