ID I3M1X7_ICTTR Unreviewed; 737 AA.
AC I3M1X7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=N-acetylated alpha-linked acidic dipeptidase like 1 {ECO:0000313|Ensembl:ENSSTOP00000002901.3};
GN Name=NAALADL1 {ECO:0000313|Ensembl:ENSSTOP00000002901.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000002901.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000002901.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane
CC protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the peptidase M28 family. M28B subfamily.
CC {ECO:0000256|ARBA:ARBA00005634}.
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DR EMBL; AGTP01072425; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01072426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3M1X7; -.
DR STRING; 43179.ENSSTOP00000002901; -.
DR MEROPS; M28.011; -.
DR Ensembl; ENSSTOT00000003249.3; ENSSTOP00000002901.3; ENSSTOG00000003242.3.
DR eggNOG; KOG2195; Eukaryota.
DR GeneTree; ENSGT01030000234598; -.
DR HOGENOM; CLU_005688_3_2_1; -.
DR InParanoid; I3M1X7; -.
DR TreeFam; TF312981; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
DR GO; GO:0043171; P:peptide catabolic process; IEA:Ensembl.
DR CDD; cd08022; M28_PSMA_like; 1.
DR CDD; cd02121; PA_GCPII_like; 1.
DR Gene3D; 3.50.30.30; -; 1.
DR Gene3D; 1.20.930.40; Transferrin receptor-like, dimerisation domain; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR046450; PA_dom_sf.
DR InterPro; IPR003137; PA_domain.
DR InterPro; IPR007484; Peptidase_M28.
DR InterPro; IPR039373; Peptidase_M28B.
DR InterPro; IPR007365; TFR-like_dimer_dom.
DR InterPro; IPR036757; TFR-like_dimer_dom_sf.
DR PANTHER; PTHR10404:SF50; AMINOPEPTIDASE NAALADL1; 1.
DR PANTHER; PTHR10404; N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE; 1.
DR Pfam; PF02225; PA; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR Pfam; PF04253; TFR_dimer; 1.
DR SUPFAM; SSF52025; PA domain; 1.
DR SUPFAM; SSF47672; Transferrin receptor-like dimerisation domain; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022968}.
FT DOMAIN 160..244
FT /note="PA"
FT /evidence="ECO:0000259|Pfam:PF02225"
FT DOMAIN 345..552
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT DOMAIN 613..731
FT /note="Transferrin receptor-like dimerisation"
FT /evidence="ECO:0000259|Pfam:PF04253"
SQ SEQUENCE 737 AA; 80200 MW; 03A00696F34B026E CRC64;
MQWVKVLGLG LGAAALLGLG IILGHFAIPK GADAPDLDLE LLKAVMGQLD ASKIRENLWE
LSRQPHLASS PRDEALVQLL LSRWRDSESG LDSAERTEYE VLLSFPSQEQ PNLVEVVGPT
GDILHTYHPK EENVTGEQGG PDVVQPYAAY APPGTPQGLL VYAYQGKEED FKELQEQGIN
LEGTIALTRY GGAGRGDKAV NAAKYGVAGV LVYTDPMDVN DGQSLPSQTF PNSWGLPPSG
VERGSYYKYF GDPVTPYLPA HHSSFRVDHS NASGFPPIPA QPIGFQDAKD LLCNLNGTLA
PSAWQGALGC EYRLGPGFRS SGSLSDGSQV RMSVYNRLEL RNSSNVLGII RGAVEPDRYV
LYGNHRDSWV HGAVDPSSGT AVLLEISQVL GTLLKKGTWR PRRSIVFASW GAEEFGLIGS
TEFTEEFFSK LQERTVAYIN VDVAVMANAT LRVLGTPPVQ SVVFSATKEI DSPGPSGPSI
YDNWKRHFNR SSPVYGTVPS LGALGAGSDY APFIHFLGIS SVDMTYTYDR SKTSARIYPT
YHTAFDTFDY MEKFLDPGFS SHQAVARTAG NVLLRLSDSL FLPLNVSDYS EVLHSFLRAA
QQELGNLLQQ HNISLGPLVT AVEKFAVAAS ALDQHVSAQR KGSPDPLQVR MFNDQLMLLE
RAFLNSRAFP EERYYSHVLW APHSSSVATF PGLANACYRA KDTDAGSEAW AEVQRQLSIV
VAALEGATAT LRPVAEL
//
