ID I3M3F4_ICTTR Unreviewed; 786 AA.
AC I3M3F4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Cyclic nucleotide gated channel subunit beta 3 {ECO:0000313|Ensembl:ENSSTOP00000003597.3};
GN Name=CNGB3 {ECO:0000313|Ensembl:ENSSTOP00000003597.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000003597.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000003597.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AGTP01053772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3M3F4; -.
DR STRING; 43179.ENSSTOP00000003597; -.
DR Ensembl; ENSSTOT00000004013.3; ENSSTOP00000003597.3; ENSSTOG00000004002.3.
DR eggNOG; KOG0499; Eukaryota.
DR GeneTree; ENSGT00940000154824; -.
DR HOGENOM; CLU_005746_11_1_1; -.
DR InParanoid; I3M3F4; -.
DR OrthoDB; 74296at2759; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0001750; C:photoreceptor outer segment; IEA:Ensembl.
DR GO; GO:1902495; C:transmembrane transporter complex; IEA:Ensembl.
DR GO; GO:0030553; F:cGMP binding; IEA:Ensembl.
DR GO; GO:0005223; F:intracellular cGMP-activated cation channel activity; IEA:Ensembl.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45638:SF8; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL BETA-3; 1.
DR PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 212..233
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 348..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 519..623
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 691..753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..26
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..76
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..104
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..737
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 786 AA; 89596 MW; 91ADED1E3E08FA18 CRC64;
MFKSLRIKFN KVQPTEENHE KGHGSHPSHQ AQQSPGQEEN KSEEMSLKTK RTPITSEEPH
IKTQDKDSEK NSSRDLTTKP DPQSPMESSR TKSEQKEMGT ENEEAISPKS KPPGAPVINE
YADAQLHNLV QRMRQRTALY KKKLIDGELS SPEASPQKAK PTAVAPTQES DSKLKKEDYQ
GMLCWKFQKA PLREYLKKIR LPGSIDSHTD RLYLLWLLLV TIAYNWNCWF IPLRLFFPYQ
TPDNTLYWLI VDIICDIIYV SDMLFIQPRI QFVKGGDIIV EPNELKKHYK SSIKYQLDVA
SVIPFDVLYF FFGFNPVFRT NRVLKYTSFF EFNHHLESIM EKAYIYRVIR TTGYLLFILH
INACIYYWAS SYEGIGTTRW VYNGEGNKYL RCYYWAVRTL ITIGGLPEPQ TTFEIIFQLL
NFFSGVFVFS SLIGQMRDVI GAATANQNNF RASMDNTTAY MNTYSIPQIV QTRVRTWFEY
TWDSQRMLDE SDLLETLPGT MQLSLAIDMN FSIISKVELF KNCDNQMIYD MLLRLKSTIY
LPGDFVCKKG EIGKEMYIIK HGEVQVLGGP DGTKVLVTLK AGAVFGEISL LASGGGNRRT
ANVVAHGFAN LLTLDKKTLQ EILVHYPDSE KLLMKKARVL LKQKGGNKEA TPPRKGLALL
FQPKEKTPKM FRALLGGTGD IGRLLKLKRE QEAQEKCESP KEEDKGKENE DKGKENEDKG
REPAEKTPDK SKCKESSIAA EEMPPSVERA VLPRGTSNQS LIISMAPSAE AGEEVLTIEV
KEKAEQ
//
